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Cariology, Restorative Sciences, and Endodontics

Marco C. Bottino, D.D.S., MSc., Ph.D., FADM

Associate Professor

Cariology, Restorative Sciences, and Endodontics
School of Dentistry, Room 5223
University of Michigan
1011 N University
Ann Arbor, MI 48109-1078
734-763-2206 | Bottino Lab


Marco C. Bottino, DDS, MSc, PhD, FADM, holds the position of Associate Professor (tenured) in the Department of Cariology, Restorative Sciences, and Endodontics at the University of Michigan School of Dentistry. Before joining the University of Michigan, he was an Associate Professor of Biomedical and Applied Sciences and Graduate Program Director in Dental Biomaterials at Indiana University School of Dentistry. He received his Doctorate of Dental Science (DDS) degree in 2001 from Universidade Paulista (São Paulo, Brazil), his master’s degree in Nuclear Technology (Materials) in 2005 from the University of São Paulo (Institute for Energy & Nuclear Research, São Paulo, Brazil), and his doctorate in Materials Science in 2010 from The University of Alabama at Birmingham (Birmingham, AL). Marco has received Young Investigator Awards from the International Association for Dental Research (IADR) Pulp Biology and Implantology Research Groups and a prestigious Mentored Clinical Scientist Research Career Development Award from the National Institute for Dental and Craniofacial Research (NIDCR). He has served as a member of National Institutes of Health (NIH) study sections and has been the principal investigator for several NIH, foundations, and industry grants. Marco is an elected Fellow of the Academy of Dental Materials (ADM) and the Vice-President of the Dental Materials Group (DMG) of the International Association for Dental Research. Marco is a member of the editorial board of several journals. His research interests are in the design and synthesis of tissue scaffolds, drug delivery systems, and stem cell therapies to regenerate dental, oral, and craniofacial tissues. His current research foci are the development of drug delivery system for ablating oral infection, injectable scaffolds for pulp-dentin complex regeneration, multiphasic and tissue specific scaffolds for periodontal tissue reconstruction. More recently, with the acquisition of a unique BioPrinting platform, his laboratory will continue to expand the regenerative dentistry program to address other oral and craniofacial challenges.

Recent Publications:

Regenerative Dentistry

Karczewski A, Feitosa SA, Hamer EI, Pankajakshan D, Gregory RL, Spolnik KJ, Bottino MC. Clindamycin-modified triple antibiotic nanofibers: A stain-free antimicrobial intracanal drug delivery system. J Endod. 2018;44(1):155-162.

Bottino MC, Pankajakshan D, Nör JE. Advanced scaffolds for dental pulp and periodontal regeneration. Dent Clin North Am. 2017;61(4):689-711.

Albuquerque MTP, Nagata J, Bottino MC. Antimicrobial efficacy of triple antibiotic-eluting polymer nanofibers against multispecies biofilm. J Endod. 2017;43(9S):S51-S56.

Münchow EA, Pankajakshan D, Albuquerque MT, Kamocki K, Piva E, Gregory RL, Bottino MC. Synthesis and characterization of CaO-loaded electrospun matrices for bone tissue engineering. Clin Oral Investig. 2016;20(8):1921-1933.

Pankajakshan D, Albuquerque MT, Evans JD, Kamocka MM, Gregory RL, Bottino MC. Triple antibiotic polymer nanofibers for intracanal drug delivery: effects on dual species biofilm and cell function. J Endod. 2016;42(10):1490-5.

Shahi RG, Albuquerque MTP, Münchow EA, Blanchard SB, Gregory RL, Bottino MC. Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating. Odontology. 2017;105(3):354-363.

Bottino MC, Münchow EA, Albuquerque MTP, Kamocki K, Shahi R, Gregory RL, Chu TG, Pankajakshan D. Tetracycline-incorporated polymer nanofibers as a potential dental implant surface modifier. J Biomed Mater Res B Appl Biomater. 2017;105(7):2085-2092.

Porter ML, Münchow EA, Albuquerque MT, Spolnik KJ, Hara AT, Bottino MC. Effects of novel 3-dimensional antibiotic-containing electrospun scaffolds on dentin discoloration. J Endod. 2016;42(1):106-12.

Albuquerque MT, Evans JD, Gregory RL, Valera MC, Bottino MC. Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm. Clin Oral Investig. 2016;20(2):387-93.

Rowe MJ, Kamocki K, Pankajakshan D, Li D, Bruzzaniti A, Thomas V, Blanchard SB, Bottino MC. Dimensionally stable and bioactive membrane for guided bone regeneration: An in vitro study. J Biomed Mater Res B Appl Biomater. 2016;104(3):594-605.

Bottino MC, Yassen GH, Platt JA, Labban N, Windsor LJ, Spolnik KJ, Bressiani AH. A novel three-dimensional scaffold for regenerative endodontics: materials and biological characterizations. J Tissue Eng Regen Med. 2015;9(11):E116-23.

Bottino MC, Thomas V. Membranes for periodontal regeneration--A materials perspective. Front Oral Biol. 2015;17:90-100.

Münchow EA, Albuquerque MT, Zero B, Kamocki K, Piva E, Gregory RL, Bottino MC. Development and characterization of novel ZnO-loaded electrospun membranes for periodontal regeneration. Dent Mater. 2015;31(9):1038-51.

Chen X, Song F, Jhamb D, Li J, Bottino MC, Palakal MJ, Stocum DL. The axolotl fibula as a model for the induction of regeneration across large segment defects in long bones of the extremities. PLoS One. 2015;10(6):e0130819.

Kamocki K, Nör JE, Bottino MC. Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability-In vitro studies. Arch Oral Biol. 2015;60(8):1131-7.

Albuquerque MT, Ryan SJ, Münchow EA, Kamocka MM, Gregory RL, Valera MC, Bottino MC. Antimicrobial effects of novel triple antibiotic paste-mimic scaffolds on Actinomyces naeslundii biofilm. J Endod. 2015;41(8):1337-43.

Albuquerque MT, Valera MC, Moreira CS, Bresciani E, de Melo RM, Bottino MC. Effects of ciprofloxacin-containing scaffolds on enterococcus faecalis biofilms. J Endod. 2015;41(5):710-4.

Kamocki K, Nör JE, Bottino MC. Dental pulp stem cell responses to novel antibiotic-containing scaffolds for regenerative endodontics. Int Endod J. 2015;48(12):1147-56.

Albuquerque MT, Valera MC, Nakashima M, Nör JE, Bottino MC. Tissue-engineering-based strategies for regenerative endodontics. J Dent Res. 2014;93(12):1222-31.

Palasuk J, Kamocki K, Hippenmeyer L, Platt JA, Spolnik KJ, Gregory RL, Bottino MC. Bimix antimicrobial scaffolds for regenerative endodontics. J Endod. 2014;40(11):1879-84.

Waeiss RA, Negrini TC, Arthur RA, Bottino MC. Antimicrobial effects of drug-containing electrospun matrices on osteomyelitis-associated pathogens. J Oral Maxillofac Surg. 2014;72(7):1310-9.

Halum SL, Bijangi-Vishehsaraei K, Zhang H, Sowinski J, Bottino MC. Stem cell-derived tissue-engineered constructs for hemilaryngeal reconstruction. Ann Otol Rhinol Laryngol. 2014;123(2):124-34.

Bottino MC, Arthur RA, Waeiss RA, Kamocki K, Gregson KS, Gregory RL. Biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. Clin Oral Investig. 2014;18(9):2151-8.

Bottino MC, Kamocki K, Yassen GH, Platt JA, Vail MM, Ehrlich Y, Spolnik KJ, Gregory RL. Bioactive nanofibrous scaffolds for regenerative endodontics. J Dent  Res. 2013;92(11):963-9.

Bottino MC, Thomas V, Schmidt G, Vohra YK, Chu TM, Kowolik MJ, Janowski GM. Recent advances in the development of GTR/GBR membranes for periodontal regeneration--a materials perspective. Dent Mater. 2012;28(7):703-21.

Bottino MC, Thomas V, Janowski GM. A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration. Acta Biomater. 2011;7(1):216-24.

Dental Biomaterials

Münchow EA, Bottino MC. Recent advances in adhesive bonding - The role of biomolecules, nanocompounds, and bonding strategies in enhancing resin bonding to dental substrates. Curr Oral Health Rep. 2017;4(3):215-227.

Palasuk J, Windsor LJ, Platt JA, Lvov Y, Geraldeli S, Bottino MC. Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion. Clin Oral Investig. 2017 Sep 30.

Al-Shehri EZ, Al-Zain AO, Sabrah AH, Al-Angari SS, Al Dehailan L, Eckert GJ, Özcan M, Platt JA, Bottino MC. Effects of air-abrasion pressure on the resin bond strength to zirconia: a combined cyclic loading and thermocycling aging study. Restor Dent Endod. 2017;42(3):206-215.

Borges ALS, Posritong S, Özcan M, Campos F, Melo R, Bottino MC. Can cleansing regimens effectively eliminate saliva contamination from lithium disilicate ceramic surface? Eur J Prosthodont Restor Dent. 2017;25(1):9-14.

Huang NC, Bottino MC, Levon JA, Chu TG. The effect of polymerization methods and fiber types on the mechanical behavior of fiber-reinforced resin-based composites. J Prosthodont. 2017;26(3):230-237.

Prochnow C, Venturini AB, Grasel R, Bottino MC, Valandro LF. Effect of etching with distinct hydrofluoric acid concentrations on the flexural strength of a lithium disilicate-based glass ceramic. J Biomed Mater Res B Appl Biomater. 2017;105(4):885-891.

Backer AD, Münchow EA, Eckert GJ, Hara AT, Platt JA, Bottino MC. Effects of simulated gastric juice on CAD/CAM resin composites-morphological and mechanical evaluations. J Prosthodont. 2017;26(5):424-431.

Münchow EA, Hamann HJ, Carvajal MT, Pinal R, Bottino MC. Stain removal effect of novel papain- and bromelain-containing gels applied to enamel. Clin Oral Investig. 2016;20(8):2315-2320.

Angkasith P, Burgess JO, Bottino MC, Lawson NC. Cleaning methods for zirconia following salivary contamination. J Prosthodont. 2016;25(5):375-9.

Feitosa SA, Münchow EA, Al-Zain AO, Kamocki K, Platt JA, Bottino MC. Synthesis and characterization of novel halloysite-incorporated adhesive resins. J Dent. 2015;43(11):1316-22.

Venturini AB, Prochnow C, May LG, Bottino MC, Felipe Valandro L. Influence of hydrofluoric acid concentration on the flexural strength of a feldspathic ceramic. J Mech Behav Biomed Mater. 2015;48:241-248.

Borges ALS, Münchow EA, de Oliveira Souza AC, Yoshida T, Vallittu PK, Bottino MC. Effect of random/aligned nylon-6/MWCNT fibers on dental resin composite reinforcement. J Mech Behav Biomed Mater. 2015;48:134-144.

Pereira G, Amaral M, Cesar PF, Bottino MC, Kleverlaan CJ, Valandro LF. Effect of low-temperature aging on the mechanical behavior of ground Y-TZP. J Mech Behav Biomed Mater. 2015;45:183-92.

Alkatheeri MS, Palasuk J, Eckert GJ, Platt JA, Bottino MC. Halloysite nanotube incorporation into adhesive systems—effect on bond strength to human dentin. Clin Oral Investig. 2015;19(8):1905-12.

Bottino MA, Snellaert A, Bergoli CD, Özcan M, Bottino MC, Valandro LF. Effect of ceramic etching protocols on resin bond strength to a feldspar ceramic. Oper Dent. 2015;40(2):E40-6.

Cook NB, Feitosa SA, Patel A, Alfawaz Y, Eckert GJ, Bottino MC. Bonding ability of paste-paste glass ionomer systems to tooth structure: in vitro studies. Oper Dent. 2015;40(3):304-12.

Hamilton MF, Otte AD, Gregory RL, Pinal R, Ferreira-Zandoná A, Bottino MC. Physicomechanical and antibacterial properties of experimental resin-based dental sealants modified with nylon-6 and chitosan nanofibers. J Biomed Mater Res B Appl Biomater. 2015;103(8):1560-8.

Feitosa SA, Patel D, Borges AL, Alshehri EZ, Bottino MA, Özcan M, Valandro LF, Bottino MC. Effect of cleansing methods on saliva-contaminated zirconia—an evaluation of resin bond durability. Oper Dent. 2015;40(2):163-71.

Nishigori A, Yoshida T, Bottino MC, Platt JA. Influence of zirconia surface treatment on veneering porcelain shear bond strength after cyclic loading. J Prosthet Dent. 2014;112(6):1392-8.

Feitosa SA, Palasuk J, Kamocki K, Geraldeli S, Gregory RL, Platt JA, Windsor LJ, Bottino MC. Doxycycline-encapsulated nanotube-modified dentin adhesives. J Dent Res. 2014;93(12):1270-6.

Luangruangrong P, Cook NB, Sabrah AH, Hara AT, Bottino MC. Influence of full-contour zirconia surface roughness on wear of glass-ceramics. J Prosthodont. 2014;23(3):198-205.

Borges AL, Borges AB, Xavier TA, Bottino MC, Platt JA. Impact of quantity of resin, C-factor, and geometry on resin composite polymerization shrinkage stress in Class V restorations. Oper Dent. 2014;39(2):144-51.

Bottino MC, Batarseh G, Palasuk J, Alkatheeri MS, Windsor LJ, Platt JA. Nanotube-modified dentin adhesive--physicochemical and dentin bonding characterizations. Dent Mater. 2013;29(11):1158-65.

Sabrah AH, Cook NB, Luangruangrong P, Hara AT, Bottino MC. Full-contour Y-TZP ceramic surface roughness effect on synthetic hydroxyapatite wear. Dent Mater. 2013;29(6):666-73.

Posritong S, Borges AL, Chu TM, Eckert GJ, Bottino MA, Bottino MC. The impact of hydrofluoric acid etching followed by unfilled resin on the biaxial strength of a glass-ceramic. Dent Mater. 2013;29(11):e281-90.

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