Skip to content Skip to navigation

Cariology, Restorative Sciences, and Endodontics

Helena Ritchie, MS, PhD

Helena Ritchie photographAssociate Professor

Cariology, Restorative Sciences and Endodontics
School of Dentistry, Room 2303
University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078
TEL = 734-763-3746
FAX = 734-936-1597
Additional information | Complete CV  | Research



Major Responsibilities:

Course Director, DENTXXX, IMS Module 1
Course Director, DENTED606, Mineralized Tissues

Special Distinctions:

Undergraduate Research Opportunity Program Faculty Recognition Award (2007)

Description of Research:

Dr. Ritchie is focused on studying two major dentin noncollagenous proteins -- dentin sialoprotein (DSP) and physophporyn (PP) -- whose appearance is coupled to the conversion of uncalcified predentin to calcified dentin.  The work encompassess following four DSP-PP related areas: (1) regulation and function of rat dentin sialoprotein and phosphophoryn, (2) tissue engineering to test whether DSP and PP proteins can serve as biomimetic molecules in promoting dentin regeneration, (3) DSP-PP gene expression in non-mineralized tissues such as bone, kidney and salivary glands during organogenesis, and (4) DSP-PP precursor processing studies.



  1. Yang RT, Lim GL, Dong ZH, Lee AR, Yee CT, Fuller RS, Ritchie HH.  The efficiency of Dentin sialoprotein-Phosphophoryn processing by mutations both flanking and distrant from the clevage site. J Biol Chem 2013 February 22; 288(8): 6024-6033.
  2. Ritchie HH, Yee CT, Tang X, Fuller RS.  DSP-PP Precursor Protein Cleavage by Toll related-1 protein and Bone Morphogenetic Protein-1.  PLoS ONE 2012 July; 7(7):341110.
  3. Tang XN, Zhu YQ, Marcelo CL, Ritchie HH.  Expression of mineralized tissue associated proteins: Dentin sialoprotein and phosphophoryn in rodent hair follicles. J Dermatological Science 2011 Nov; 64(2): 92-98.
  4. li LF, Zhu YQ, Jiang L, Peng WW, Ritchie HH.  Hypoxia promotes mineralization of human dental pulp cells.  J Endod 2011 April; 37(6): 799-802.


Return to Faculty page 


updated 01/02/2014