Loesche WJ. Bradbury DR. Woolfolk MP. Reduction of dental decay in rampant caries individuals following short-term kanamycin treatment. Journal of Dental Research. 56(3):254-65, 1977 Mar.
A week of kanamycin gel treatment before and after the placement of dental restorations, compared to a placebo gel treatment, significantly reduced the levels of cultivable bacteria, S mutans and S sanguis, in the plaque samples collected immediately after the completion of the gel treatments, and was associated with a 46% reduction in new carious surfaces in the 14- to 37-month period following the gel treatment.