Laurie K. McCauley, DDS, PhD

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William K. and Mary Anne Najjar Professor Professor and Chair, Department of Periodontics and Oral Medicine Associate Professor, Department of Pathology, Medical School
Department of Periodontics and Oral Medicine University of Michigan School of Dentistry 1101 N. University Ann Arbor, Mi 48109-1078	Phone: (734) 763-2105 email: mccauley@umich.edu

Education

Biography

Research Interests

Hormonal controls of bone remodeling. Anabolic actions of parathyroid hormone (PTH), parathyroid hormone-related protein (PTHrP) and their dependence on the PTH-1 receptor and AP-1 transcription factors to evoke their anabolic actions. The role of PTHrP in skeletal specific processes such as bone metastasis and tooth eruption. The dependence of sex steroids on actions of parathyroid hormones in bone.

Selected Recent Publications

Datta NS, Chen C, Berry JE, McCauley LK. PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest. J Bone Miner Res 20:1051-64, 2005. 

Schneider A, Kalikin LM, Mattos AC, Keller ET, Allen MJ, Pienta KJ, McCauley LK.  Bone turnover mediates preferential localization of prostate cancer in the skeleton.  Endocrinology   146:1727-1736, 2005. 

Pettway GJ, Schneider A, Koh AJ, Widjaja E, Morris MD, Meganck JA, Goldstein SA, McCauley LK. Anabolic actions of PTH (1-34):  Use of a novel tissue engineering model to investigate temporal effects on bone. Bone 36:959-970, 2005.

Koh AJ, Demiralp B, Neiva K, Hooten J., Nohutcu RM, Shim H, Datta NS, Taichman RS, McCauley L.K. Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology: 146:4584-4596, 2005.

Tozum TF, Oppenlander M, Koh-Paige AJ, Robins D, McCauley LK. Effects of Sex Steroid Receptor Specificity in the Regulation of Skeletal Metabolism. Calcified Tissue International, 75:60-70, 2004. 

Chen C, Koh AJ, Datta NS, Zhang J, Keller ET, Xiao G, Franceschi RT, D’Silva NJ, McCauley LK. Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts. J Biological Chemistry, 279:29121-29129, 2004.

Chen H, Frankenberg L, Goldstein S, McCauley LK.  The combination of local and systemic PTH enhances fracture healing. Clinical Orthopedics and Related Research, 416:291-302, 2003. 

Chen H, Demiralp B, Schneider A, Koh AJ, Silve C, Wang C, McCauley LK. Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. Journal of Biological Chemistry , 277:19374-19381, 2002. 

Demiralp B, Chen H, Koh AJ, Keller ET, McCauley LK.  Anabolic effects of parathyroid hormone during endochondral bone growth are dependent on c-fos.  Endocrinology: 143:4038-4047, 2002. 

Lab Personnel

	Jan Berry, B.S., jeberry@umich.edu Senior Research Associate
	Nabanita Datta, Ph.D., nsdatta@umich.edu Assistant Research Scientist
	Joanna Hooten, B.S., jhooten@umich.edu Research Assistant II
	Amy Koh, B.S., ajkoh@umich.edu Research Associate II
	Glenda Pettway, B.S., M.S.E gpettway@umich.edu Ph.D. Student
	Abraham Schneider, D.D.S. aschneiz@umich.edu Oral Health Sciences Ph.D. Student
	Chuen-Long Wei, Ph.D., clcwei@umich.edu Research Associate I
	Junro Yamashita, D.D.S., yamashit@umich.edu Research Fellow

Last updated: Monday, November 21, 2005