Professor

Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave
Ann Arbor, MI 48109-1078
Phone: 734-615-2295
email: ykapila@umich.edu
 
Recent Publications
Kapila Lab

Education

1997-1998 - Cell Biology, Postdoctorate, Stanford University, Stanford CA
1997 - PhD, Oral Biology, University of California, San Francisco CA
1994 - Certificate, Periodontology, University of California, San Francisco CA
1990 - DDS, BS, Dentistry, University of California, San Francisco CA
1986 - BA, Human Biology, Stanford University, Stanford CA

Professional Experience

2011-present - Professor, Department of Periodontics/Prevention/Geriatrics, University of Michigan
2004-2011 - Associate Professor,  Department of Periodontics/Prevention/Geriatrics, University of Michigan
1999-2004 - Assistant Professor, Department of Stomatology, Division of Periodontology UCSF
1997-1999 - Assistant Adjunct Professor, Department of Stomatology, Division of Periodontology UCS
1994-1997 - Assistant Research, Department of Stomatology, Division of Periodontology UCSF
1993-1994 - Visiting Assistant Research, Department of Stomatology, UCSF
1991-1994 - Dentist in private practice in San Francisco, one half day per week
1991-1993 - Postgraduate Research, Department of Stomatology, Division of Periodontology, UCSF
1983-1986 - Lab Assistant, Stanford University/VA Hospital (Neuropath Lab Dr. Lawrence Eng)

Recent Honors and Awards

2006-present - NIH ODCS Study Section Reviewer-Standing Member
2006 - NIH ODCS Study Section Reviewer- Ad Hoc Member
2000 - UCSF Faculty Development Award
1997 - Winner of the Edward H. Hatton Awards of the American Association for Dental Research
1997 - Winner of the Baliant Orban Research Competition-American Academy of Periodontology

Research Interests

My lab focuses on three main areas of research. One area involves understanding the underlying cell-matrix interactions that govern disease progression in inflammatory diseases such as periodontal tissues. These studies encompass both basic cell and molecular biology studies and patient/translational investigations. Another related area that our lab has recently embarked on relates to expanding our understanding of the mechanisms by which matrix metalloproteinases (MMPs) triggered by inflammatory disease-modulated-matrices may enhance osteoclast activity and diminish osteoblast differentiation. Lastly, the other main area of research in my lab involves understanding the cell-matrix interactions that govern cell survival and invasion/migration of squamous cell carcinomas.
 
See Kapila Lab

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Recent Publications

Joseph J, Kapila YL, Hayami T, Kapila S. Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1. Calcif Tissue Int. 2010 Feb;86(2):154-62. Epub 2009 Dec 2. PubMed PMID: 19953231.

Paula-Silva FW, da Silva LA, Kapila YL. Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment. J Endod. 2010 Feb;36(2):231-7. PMID: 20113780.

Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila YL. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell. 2010 Feb;21(3):481-8. Epub 2009 Dec 2. PubMed PMID: 19955213; PubMed Central PMCID: PMC2814792. 

Daniels TE, Kapila YL. Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan;109(1); author reply 4. Epub 2009 Oct 14. PubMed PMID: 19828340.

de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila YL. High matrix metalloproteinase activity is a hallmark of periapical granulomas. J Endod. 2009 Sep;35(9):1234-42. PubMed PMID: 19720222; PubMed Central PMCID: PMC2736957.

Paula-Silva FW, Ghosh A, Silva LA, Kapila YL. TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res. 2009 Apr;88(4):339-44. PubMed PMID: 19407154.

Xu J, Wang W, Kapila Y, Lotz J, Kapila S. Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Stem Cells Dev. 2009 Apr;18(3):487-96. PubMed PMID: 18593336; PubMed Central PMCID: PMC2702120.

Ghosh A, Park JY, Fenno C, Kapila YL. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infect Immun. 2008 Dec;76(12):5514-23. Epub 2008 Oct 6. PubMed PMID: 18838522; PubMed Central PMCID: PMC2583576.

Hayami T, Kapila YL, Kapila S. MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biol. 2008 Oct;27(8):682-92. Epub 2008 Aug 5. PubMed PMID: 18755271; PubMed Central PMCID: PMC2683744.

Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation. Cell Death Differ. 2008 May;15(5):899-907. Epub 2008 Feb 22. PubMed PMID: 18292781.

Kamarajan P, Kapila YL. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis. 2007 Dec;12(12):2221-31. PubMed PMID: 17879163.

Hayami T, Zhang Q, Kapila Y, Kapila S. Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression. Bone. 2007 Jan;40(1):93-104. Epub 2006 Aug 24. PubMed PMID: 16934542.

Tafolla E, Wang S, Wong B, Leong J, Kapila YL. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem. 2005 May 20;280(20):19992-9. Epub 2005 Mar 18. PubMed PMID: 15778501.

Dai R, Iwama A, Wang S, Kapila YL. Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed. Apoptosis. 2005 May;10(3):503-12. PubMed PMID: 15909113.

Lu H, Jin D, Kapila YL. Application of laser capture microdissection to phage display peptide library screening. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):692-7. PubMed PMID: 15583542.

Zhang Y, Lu H, Dazin P, Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem. 2004 Nov 12;279(46):48342-9. Epub 2004 Aug 24. PubMed PMID: 15331608.

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