Assistant Professor

Division of Oral Pathology/Medicine/Radiology
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave Rm #3210
Ann Arbor, MI 48109-1078
734-615-3406   |  csquariz@umich.edu

  - Recent Publications
 

Education

2003 - 2009 - Post-Doctorate, Oral Pharyngeal Cancer Branch (OPCB) at the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA
2005 - PhD, Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
2003 - MS, Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
1995 - DDS, Pontific Catholic University of Campinas, Campinas, Brazil

Honors and Awards

2003 - 2005 - Fellowship award for post-doctoral training, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
2003 - Fellowship award for PhD education, FAPESP (Foundation for the support of research from the State of Sao Paulo)
2002 - Unilever Travel Award, International Association of Dental Research (IADR), 80th Meeting of the International Association for Dental Research/AADR/CADR
2001 - 2003 - Fellowship award for Master of Science education, FAPESP (Foundation for the support of research from the State of Sao Paulo)
2001 - Edward H Hatton, IADR Brazilian Division - (First Prize) - Brazilian Society of Dentistry for research (SBPqO)

Academic Appointments and Professional Experience

2010 - present - Assistant Professor, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
2001 - 2003 – Surgical and Experimental Pathology training and service, University of Sao Paulo, Sao Paulo, Brazil
1996 - 2001 - Dental Surgeon, Proprietor, Private Practice, Campinas, Brazil

Research Interests

• Head and Neck Cancers
• Tumor Suppressors
• Stem Cells
• Wound-Healing and Tissue Regeneration
• Pathology

back to top

Recent Publications

Squarize CH, Castilho RM, Bugge TH, Gutkind JS. Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models. PLoS One. 2010 (in press).

Castilho RM, Squarize CH, Bugge TH, Gutkind JS. Rac1 Is Required for Epithelial Stem Cell Function during Dermal and Oral Mucosal Wound Healing but not for Tissue Homeostasis in Mice. PLoS One. 2010 (in press).

Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt- induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 2009 Sep; 4;5(3):279- 89. PubMed PMID: 19733540.

Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. Dysregulated Molecular Networks in Head and Neck Carcinogenesis. Oral Oncol. 2009 Apr-May;45(4-5):324-34. Pubmed PMID: 18805044.

Squarize CH, Castilho RM, Gutkind JS. Chemoprevention and Treatment of Experimental Cowden’s Disease by mTOR Inhibition with Rapamycin. Cancer Res. 2008 Sep 1;68(17):7066-72. PubMed PMID: 18757421.

Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 2;26(35):5078-85. PubMed PMID: 17334398.

Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr, Gutkind JS. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9): 733-46. PubMed PMID: 16984731.

Castilho RM, Squarize CH, Nunes FD, Pinto DS Jr. Osteolipoma: a rare lesion in the oral cavity. The British Journal of Oral & Maxillofacial Surgery. 2004 Aug; 42(4): 363-4. PubMed PMID: 15225961.

Squarize CH, Castilho RM, Pinto DS Jr. Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. Journal of Oral Pathology & Medicine. 2002 Aug; 31(7): 379-84. PubMed PMID: 12224530.

Book Chapters

Squarize CH, Castilho RM, Leopoldino AM. Drug Target Validation. Current Methods in Medicinal Chemistry and Biological Physics Vol. 2. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 167-186, 2008.

Squarize CH, Castilho RM. Emerging animal models. In Current Methods in Medicinal Chemistry and Biological Physics. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 207-226, 2007.

back to top