Professor of Dentistry and Director of University of Michigan Scholars Program in Dental Leadership
Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave
Ann Arbor, MI 48109-1078
734-764-9952
rtaich@umich.edu
Recent Publications
Education
1983 - BS, Villanova University
1986 - DMD, University of Pennsylvania
1990 - DMSc, Harvard University
1990 - Certificate in Periodontics, Harvard University
1992 - Post-Doctoral Fellowship, University of Pennsylvania
Academic Appointments and Professional Experience
2005-present - Professor, Department of Periodontics and Oral Medicine
1998-2005 - Associate Professor, Department of Periodontics, Prevention, &Geriatrics, University of Michigan School of Dentistry
1998-present - Consultant; Dental Service, Ann Arbor VA Medical Center
1992-1998 - Assistant Professor, Department of Periodontics, Prevention & Geriatrics, University of Michigan School of Dentistry
1991-1992 - Consultant, Dental Service, Philadelphia VA Medical Center
1990-1992 - Postdoctoral Research Fellow, Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine
1987-1990 - Orthopedic Research Fellow, Department of Orthopedics. Children's Hospital Corp. Boston, MA
1986-1987 - Surgical Research Fellow, Department of Surgery, Brigham and Women's Hospital, Boston MA
1986-1990 - Fellow in Periodontology, Harvard University, School of Dental Medicine
Research Interests
Research in the laboratory of Dr. Russell Taichman focuses on the role of osteoblasts in normal bone marrow function. The laboratory is currently trying to identify the osteoblast-derived factor(s) that support hematopoiesis. Identifying these mechanisms may someday ultimately reduce the morbidity/mortality associated with bone marrow transplants and will likely lead to the identification of novel methods to improve bone engraftment for regenerative therapies. Recent NIDCR grants have allowed the group to dissect the molecular events that mediate cell-to-cell adhesion between osteoblasts and hematopoietic stem cells. Part of the receptor complex that has been uncovered is novel and may be involved in how stem cells return to the marrow during bone marrow transplantation. In a second related project, the group is studying the mechanisms used by tumor cells to metastasize to the bone marrow. It has been found that part of the mechanism relates to products secreted by osteoblasts in the bone marrow that interact with receptors on tumor cells. Currently the focus is on the receptor CXCR4 (an HIV co-receptor). This receptor binds stromal derived factor-1 (SDF-1) which we believe directs the chemotaxis of prostate cancers towards the marrow. In fact, the group has recently demonstrated that blocking CXCR4 resulted in fewer tumors in animals. Recently funded projects include examinations of genetic variability in these genes that regulate tumor progression and metastasis.
Interview with Dr. Russell Taichman - Cancer Stem Cells and the Hematopoietic Stem Cell Niche.
Recent Publications
Shiozawa Y, Pedersen EA, Patel LR, Ziegler AM, Havens AM, Jung Y, Wang J, Zalucha S, Loberg RD, Pienta KJ, Taichman RS. GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche. Neoplasia. 2010 Feb;12(2):116-27. PMID: 20126470.
Song J, Kiel MJ, Wang Z, Wang J, Taichman RS, Morrison SJ, Krebsbach PH.An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood. 2010 Jan 28. [Epub ahead of print] PMID: 20110425.
Wang J, Ying G, Wang J, Jung Y, Lu J, Zhu J, Pienta KJ, Taichman RS. Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer pr ogression. Cancer Res. 2010 Jan 15;70(2):471-80. Epub 2010 Jan 12. PMID: 20068185.
Jung Y, Shiozawa Y, Wang J, Wang J, Wang Z, Pedersen EA, Lee CH, Hall CL, Hogg PJ, Krebsbach PH, Keller ET, Taichman RS. Expression of PGK1 by prostate cancer cells induces bone formation. Mol Cancer Res. 2009 Oct;7(10):1595-604. Epub 2009 Oct 13. PubMed PMID: 19825988.
Taichman RS, Green TG, Polverini PJ. Creation of a scholars program in dental leadership (SPDL) for dental and dental hygiene students. J Dent Educ. 2009 Oct;73(10):1139-43. PubMed PMID: 19805778.
Zieker D, Königsrainer I, Tritschler I, Löffler M, Beckert S, Traub F, Nieselt K, Bühler S, Weller M, Gaedcke J, Taichman RS, Northoff H, Brücher BL, Königsrainer A. Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer. Int J Cancer. 2009 Aug 17. PubMed PMID: 19688824.
Hsiao AY, Torisawa YS, Tung YC, Sud S, Taichman RS, Pienta KJ, Takayama S. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials. 2009 Jun;30(16):3020-7. Epub 2009 Mar 21. PubMed PMID: 19304321; PubMed Central PMCID: PMC2675053.
Le TT, Scheller EL, Pinsky HM, Stefanac SJ, Taichman RS. Ability of dental students to deliver oxygen in a medical emergency. J Dent Educ. 2009 Apr;73(4):499-508. PubMed PMID: 19339437.
Wang J, Lu Y, Wang J, Koch AE, Zhang J, Taichman RS. CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway. Cancer Res. 2008 Dec 15;68(24):10367-76. PubMed PMID: 19074906.
Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, Boyce BF, Calvi LM, Hadji P, McCloskey EV, Saad F, Smith MR, Suva LJ, Taichman RS, Vessella RL, Weilbaecher KN. Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clin Cancer Res. 2008 Oct 15;14(20):6387-95. Review. PubMed PMID: 18927277.
Shiozawa Y, Havens AM, Jung Y, Ziegler AM, Pedersen EA, Wang J, Wang J, Lu G, Roodman GD, Loberg RD, Pienta KJ, Taichman RS. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. J Cell Biochem. 2008 Oct 1;105(2):370-80. PubMed PMID: 18636554.
Jung Y, Song J, Shiozawa Y, Wang J, Wang Z, Williams B, Havens A, Schneider A, Ge C, Franceschi RT, McCauley LK, Krebsbach PH, Taichman RS. Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche. Stem Cells. 2008 Aug;26(8):2042-51. Epub 2008 May 22. PubMed PMID: 18499897.
Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, Taichman LS, D'Silva NJ, Gopalakrishnan R, Wang C, Giannobile WV, Taichman RS. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May;79(5):845-53. PubMed PMID: 18454663; PubMed Central PMCID: PMC2582372.
Shiozawa Y, Havens AM, Pienta KJ, Taichman RS. The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia. 2008 May;22(5):941-50. Epub 2008 Feb 28. Review. PubMed PMID: 18305549.
Lu Y, Wang J, Xu Y, Koch AE, Cai Z, Chen X, Galson DL, Taichman RS, Zhang J. CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res. 2008 Apr;6(4):546-54. Epub 2008 Mar 14. PubMed PMID: 18344492.
Havens AM, Pedersen EA, Shiozawa Y, Ying C, Jung Y, Sun Y, Neeley C, Wang J, Mehra R, Keller ET, McCauley LK, Loberg RD, Pienta KJ, Taichman RS. An in vivo mouse model for human prostate cancer metastasis. Neoplasia. 2008 Apr;10(4):371-80. PubMed PMID: 18392141; PubMed Central PMCID: PMC2288546.
Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R, Taichman RS. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 2008 Feb 15;283(7):4283-94. Epub 2007 Dec 5. PubMed PMID: 18057003.
Sun YX, Pedersen EA, Shiozawa Y, Havens AM, Jung Y, Wang J, Pienta KJ, Taichman RS. CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. Clin Exp Metastasis. 2008;25(7):765-76. Epub 2008 Jun 18. PubMed PMID: 18563594.
Keller ET, Dai J, Escara-Wilke J, Hall CL, Ignatoski K, Taichman RS, Keller J. New trends in the treatment of bone metastasis. J Cell Biochem. 2007 Dec 1;102(5):1095-102. Review. PubMed PMID: 17955492.
Taichman RS, Loberg RD, Mehra R, Pienta KJ. The evolving biology and treatment of prostate cancer. J Clin Invest. 2007 Sep;117(9):2351-61. PubMed PMID: 17786228; PubMed Central PMCID: PMC1952634.
Jung Y, Wang J, Song J, Shiozawa Y, Wang J, Havens A, Wang Z, Sun YX, Emerson SG, Krebsbach PH, Taichman RS. Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood. 2007 Jul 1;110(1):82-90. Epub 2007 Mar 14. PubMed PMID: 17360942; PubMed Central PMCID: PMC1896130.
Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007 May 1;109(9):3706-12. Epub 2007 Jan 16. Erratum in: Blood. 2007 Jul 1;110(1):17. PubMed PMID: 17227831.
Saraiva MC, Taichman RS, Braun T, Nriagu J, Eklund SA, Burt BA. Lead exposure and periodontitis in US adults. J Periodontal Res. 2007 Feb;42(1):45-52. PubMed PMID: 17214639.
Wang J, Wang J, Dai J, Jung Y, Wei CL, Wang Y, Havens AM, Hogg PJ, Keller ET, Pienta KJ, Nor JE, Wang CY, Taichman RS. A glycolytic mechanism regulating an angiogenic switch in prostate cancer. Cancer Res. 2007 Jan 1;67(1):149-59. PubMed PMID: 17210694.
Sun YX, Fang M, Wang J, Cooper CR, Pienta KJ, Taichman RS. Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. Prostate. 2007 Jan 1;67(1):61-73. PubMed PMID: 17034033.
Directions & Parking
Smoke Free Campus