Donald A. Kerr Endowed Collegiate Professor of Oral Pathology
Associate Chair, Division of Oral Medicine/Pathology/Radiology
Associate Professor, School of Dentistry
Associate Professor of Pathology, Medical School
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave Rm 5217
Ann Arbor, MI 48109-1078
734-764-1543 njdsilva@umich.edu
Bio | Recent Publications
Education
1987 - BDS (DDS), Dentistry, University of Bombay, India
1990 - MSD and certificate in Oral and Maxillofacial Pathology, Indiana University, Indianapolis, IN
1997 - PhD, University of Washington, Seattle
1998 - Certificate, Fellowship in Dental Education in the Care of the Disabled, University of Washington, Seattle
2009 - Certificate in MBA Essentials and Entrepreneurship, University of Michigan, Ross School of Business, Ann Arbor
Certification by Examination
1992 - National Board Dental Examinations (United States)
1992 - Fellow of the American Academy of Oral and Maxillofacial Pathology
1993 - Diplomate of the American Board of Oral and Maxillofacial Pathology
1997 - Western Regional Examining Board dental licensing exam (WREB)
Licensure
1997–present - Dental License, State of Washington
1999–present - Dental License, State of Michigan
National/International Professional Activities
2005-06 - Inter-Head and Neck Specialized Program in Research Excellence Pathology Working Group
2006-07 - Nominations Committee, American Academy of Oral and Maxillofacial Pathology
2007–present - Editorial Board, Oral Surgery, Oral Medicine, Oral Pathology, Endodontics
2008–present - Editorial Board, Journal of Dental Research. 2008–present - External Advisory Committtee, South Carolina COBRE grant for Oral Health Research
2009–present - Editorial Board, Head and Neck Pathology
Honors and Awards
1993-94 - Warren G. Magnuson Scholarship for academic excellence and potential for contribution to research, University of Washington
1996 - American Association for Dental Research Edward H. Hatton award winner
1996 - International Association for Dental Research Edward H. Hatton award winner
2001 - Special Dean’s Award for Research, University of Michigan
2002 - Special Dean’s Award for Research, University of Michigan
2002 – Mentor, Bradley Henson, recipient of 1st prize, Post-doc category, Dental School Research Day
2002 – Mentor, Shirley Paek, recipient of 3rd prize, Current Topics category, Dental School Research Day
2003 – Mentor, Bradley Henson, recipient of 1st prize, Post-doc category, Dental School Research Day
2003 – Mentor, Suprotim Samaddar, recipient of scholarship from Kalamazoo College, to give a presentation of his research at American Association of Dental Research in San Antonio
2004 - Selected for faculty membership of Omicron Kappa Upsilon, dental honorary society
2005 – Mentor, Bradley Henson, recipient of Djiewentskowski award, Univeristy of Michigan
2005 – Mentor, Bradley Henson, recipient of Robert Gorlin award for excellence in research, American Academy of Oral and Maxillofacial Pathology
2005 – Mentor, Bradley Henson, recipient of Hatton award, American Association of Dental Research
2006 - Crosby Award for women in science and engineering
2005-06 - Selected for ADEA leadership institute; 21 dental faculty selected nationwide
2007 – present - Donald Kerr Endowed Collegiate Professor, University of Michigan
2010 - Selected for Executive Leadership Program: Hedwig van Ameringen Executive Leadership in Academic Medicine® (ELAM) Program for Women at the Drexel University College of Medicine in Philadelphia.
Academic Appointments and Professional Experience
1987-90 - Associate Instructor, General Pathology Laboratory, Indiana University, Indianapolis, Indiana
1994-98 - Acting Instructor, Department of Oral Biology, University of Washington, Seattle, Washington
1998-07 - Assistant Professor, Department of Oral Medicine, Pathology, Oncology, University of Michigan, Ann Arbor, Michigan
1999-00 - Clinic Attending, Oral Medicine Clinic, University of Michigan
2002-07 - Director, Head and Neck Cancer Tissue Core, University of Michigan Cancer Center
2004-08 - Director, Oral and Maxillofacial Pathology Biopsy Service, University of Michigan School of Dentistry
2006-09 - Assistant Professor, Department of Pathology, University of Michigan Medical School
2007-present - Associate Professor with tenure, Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan
2007-present - Donald Kerr Endowed Collegiate Professor of Oral Pathology
2008-present - Director, Division of Oral Medicine, Pathology, Radiology
2009-present - Associate Professor, Department of Pathology, University of Michigan Medical School
Research Interests
Oral carcinogenesis: the role of ras-like proteins and galanin receptors in tumor growth and progression, focused on cell-matrix interactions as well as nuclear transport of proteins that induce transcription of genes that promote cell proliferation and invasion; identification of serum-based biomarkers for early detection of oral cancer using both basic cell and molecular biology approaches as well as translational/patient data.
Recent Publications
1. Banerjee R, Mani R, Russo N, Scanlon CS, Tsodikov A, Jing X, Cao Q, Palanisamy N, Metwally T, Inglehart RC, TomlinsS, Bradford C, Carey T, Wolf G, Kalyana-Sundaram S, Chinnaiyan A, Varambally S and D’SilvaNJ. The tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. Oncogene. 2011; 30(42):4339-49.
2. Wansom D, Light E, Thomas D, Worden F, Prince M, Urba S, Chepeha D, Kumar B, Cordell K, Eisbruch A Taylor J, Moyer J, Bradford C, D’Silva NJ, Carey T, McHugh J, Wolf G. Tumor Infiltrating Lymphocytes and Human Papillomavirus-16 Associated Oropharynx Cancer. 2011 Laryngoscope, In Press.
3. Van Tubergen E, Vander Broek R, Lee J, Wolf G, Carey T, Bradford C, Prince M, Kirkwood KL, and D’Silva NJ. Tristetraprolin regulates IL-6 which is correlated with tumor progression in head and neck squamous cell carcinoma. 2011 Cancer, 117(12):2677-89.
4. Banerjee R, Henson B, Russo N, Tsodikov A, D’Silva NJ. Rap1 mediates Galanin receptor 2-induced proliferation and survival in squamous cell carcinoma. 2011 Cellular Signalling, 23(7):1110-8.
5. Murdoch-Kinch CA, Russo N, Griffith S, Braun T, Eisbruch A, D’Silva NJ. Recovery of Salivary EGF in Parotid Saliva Following Parotid Sparing Radiation Therapy: A Proof of Principle Study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jan;111(1):64-70.
6. Zhao W, Liu M, D’Silva NJ, Kirkwood KL. Tristetraprolin Regulates IL-6 Expression Through p38 MAPK Dependent Affinity Changes with mRNA 3’UTR. J Interferon Cytokine Res. 2011 Aug;31(8):629-37.
7. Arthur AE, Duffy SA, Sanchez GI, Gruber SB, Terrell JE, Hebert JR, Bradford CR, D’Silva NJ, Carey TE, Wolf GT, Peterson KE, Rozek LS. Dietary factors associated with human papillomavirus-positive head and neck cancer: a case-only analysis. Nutr Cancer. 2011;63(5):734-42.
8. Scheller EL, Kirkpatrick CM, D’Silva NJ, Krebsbach PH, Edwards PC. Bisphosphonates inhibit expression of P63 by oral keratinocytes. J Dent Res. 2011 Jul;90(7):894-9.
9. Alhazzi T, Kamarajan P, Nam J, Verdin E, D’Silva NJ, Kapila Y. Sirtuin-3 (SIRT3), A Novel Potential Therapeutic Target for Oral Cancer. Cancer. 2011 Apr 15;117(8):1670-8. PMID: 21117229
10. Goto, M, Mitra RS, Liu M, Lee J, Henson BS, Carey T, Bradford C, Prince M, Wang C-Y, Fearon ER, D’Silva NJ. Rap1 Stabilizes b-catenin and Enhances b-catenin-dependent Transcription and Invasion in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2010; 16(1):65-76. PMID: 20028760
11. Stanbery L, D'Silva NJ, Lee JS, Bradford C, Carey T, Prince M, Wolf G, Worden F, Cordell K, and Petty EM. (2010) High SEPT9_v1 expression is associated with poor clinical outcomes in head and neck squamous cell carcinoma. Translational Oncology, 2010 Aug 1;3(4):239-45. PMID: 20689765
12. Kamarajan P, Garcia-Pardo A, D’Silva NJ, and Kapila YL. (2010) The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion. BMC Cancer. 2010 Jun 25;10:330. PMID: 20579373
13. Wansom D, Light E, Worden F, Prince M, Urba S, Chepeha D, Cordell K, Eisbruch A, Taylor J, D’Silva N, Moyer J, Bradford C, Kurnit D, Kumar B, Carey T, Wolf G. Cellular Immunity Correlates with Human Papilloma Virus-16 Status and Outcome in Patients with Advanced Oropharyngeal Cancer. Archives of Otolaryngol Head and Neck Surg, 2010 Dec;136(12):1267-73. PMID: 21173378
14. Kumar B, Cordell K, Lee JS, Worden FP, Prince ME, Tran HH, Wolf GT, Urba SG, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor J, D’Silva NJ, Yang K, Kurnit D, Bauer J, Bradford C, Carey T. EGFR, p16, HPV Titer, BCLXL and p53, Gender and Smoking as Indicators of Response to Therapy and Survival in Oropharyngeal Cancer. J Clin Oncol. 2008 Jul 1;26(19):3128-37. PMID: 18474878
15. Worden F, Kumar B, Lee JS, Wolf GT, Cordell K, Taylor J, Urba S, Eisbruch A, Teknos T, Chepeha D, Prince M, Tsien C, D’Silva NJ, Yang K, Kurnit D, Mason H, Miller T, Wallace N, Bradford C, Carey T. Chemoselection as a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated with HPV16 Copy Number. J Clin Oncol. 2008 Jul 1;26(19):3138-46. PMID: 18474879
16. Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JMG, Pan Q, Carey TE, Bradford CR, Prince ME, Cordell K, Kirkwood KL and D’Silva NJ. Rap1GAP promotes invasion via induction of MMP-9 secretion, which is associated with poor survival in early N-stage squamous cell carcinoma. Cancer Research 2008 68(10):3959-69. PMID: 18483282.
17. Henson B, Li F, Coatney DD, Carey TE, Mitra RS, Kirkwood KL, and D’Silva NJ. An orthotopic floor-of mouth model for loco-regional growth and spread of human squamous cell carcinoma. Journal of Oral Pathology and Medicine 2007, July 36(6): 363-70. PMID: 17559499
18. Bauer JA, Kumar B , Cordell KG , Prince ME, Tran HH, Wolf GT, Chepeha D, Teknos T, Wang S, Eisbruch A, Tsien C, Urba SG, Worden FP, Lee JS, Griffith K, Taylor J, D’Silva NJ, Wang S, Wolter K, Henson B, Fisher S, Carey T, Bradford CR. Targeting Apoptosis to Overcome Cisplatin Resistance: A Translational Study in Head and Neck Cancer. Int. Journal of Radiation Oncology, Biology, Physics, 2007, 69:S106-8. PMID: 17848273
19. Zhang Z, Mitra R, Henson B, Datta N, McCauley L, Kumar P, Lee J, Carey T and D’Silva NJ. Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Am J Pathol. 168(2):585-96, 2006. PMID: 16436672
20. Wolter KG, Wang, SJ, Henson B, Wang S, Griffith KA, Kumar B, Chen J, Carey TE, Bradford CR, D’Silva NJ. (-)-Gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia 2006 Mar 8(3):163-172. PMID: 16611409
21. D’Silva NJ , Summerlin D-J, Cordell KG, Abdelsayed RA, Tomich CE, Hanks CT, Fear D, Meyrowitz S. Metastatic Tumors to the Jaws: Retrospective Study of 114 cases. J Am Dent Assoc. 2006 Dec;137(12):1667-72. PMID: 17138711
22. Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D’Silva NJ. Galanin Receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. J Biological Chemistry 280(24):22564-71, 2005. PMID: 15767248
23. D’Silva NJ; Mitra R, Kurnit DM, Zhang Z, Babcock CR, Polverini PJ, Carey TE: Rap1B, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes. J Cellular Physiol. 196(3) 532-40, 2003. PMID: 12891710
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