Assistant Professor

Division of Oral Pathology/Medicine/Radiology
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave Rm 3323B
Ann Arbor, MI 48109-1078
Phone 734-647-2150 | rcastilh@umich.edu

  - Recent Publications

Education

2003 - 2009 - Post-Doctorate, Oral Pharyngeal Cancer Branch at the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA
2001 - 2003 - PhD, Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
1999 - 2000 - Master of Science (MS) in Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
1999 - 1999 - Certificate in Oral Pathology, Sao Leopoldo Mandic, Campinas, SP, Brazil
1992 - 1995 - DDS, Pontific Catholic University of Campinas, Campinas, Brazil

Honors and Awards

2003 - 2006 - Fellowship award for post-doctoral training, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH).
2001 - 2003 - Fellowship award for PhD education, CAPES (Coordination of Training of Higher Education Graduate).
2001 - Edward H. Hatton, IADR Brazilian Division (co-author, First Prize), Brazilian Society of Dentistry for research (SBPqO).
1999 - 2001 - Fellowship award for Master of Science education, CAPES (Coordination of Training of Higher Education Graduate).

Academic Appointments and Professional Experience

2010 - present - Assistant Professor, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
1999 - 2003 - Surgical and Experimental Pathology training and service, University of Sao Paulo, Sao Paulo, Brazil.
1997 - 1999 - Dental Surgeon, Private Practice, Santa Barbara D’Oeste, Brazil.
1996 - 1999 - Dental Surgeon, Private Practice, Campinas, Brazil.

Research Interests

• Epithelial Stem Cells
• Oncogene-Induced-Senescence (OIS)
• Molecular Networks of Head and Neck Cancer
• Wound-Healing and Tissue Remodeling
• Aging

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Recent Publications

Castilho RM, Squarize CH, Bugge TH, Gutkind JS. Rac1 Is Required for Epithelial Stem Cell Function during Dermal and Oral Mucosal Wound Healing but not for Tissue Homeostasis in Mice. PLoS One. 2010 (in press).

Squarize CH, Castilho RM, Bugge TH, Gutkind JS. Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models. PLoS One. 2010 (in press).

Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt- induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 2009 Sep; 4;5(3):279- 89. PubMed PMID: 19733540.

Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. Dysregulated Molecular Networks in Head and Neck Carcinogenesis. Oral Oncol. 2009 Apr-May;45(4-5):324-34. Pubmed PMID: 18805044.

Squarize CH, Castilho RM, Gutkind JS. Chemoprevention and Treatment of Experimental Cowden’s Disease by mTOR Inhibition with Rapamycin. Cancer Res. 2008 Sep 1;68(17):7066-72. PubMed PMID: 18757421.

Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007 Aug 10;317(5839):803-6. PubMed PMID: 17690294.

Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 2;26(35):5078-85. PubMed PMID: 17334398.

Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr, Gutkind JS. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9):733-46. PubMed PMID: 16984731.

Basile JR, Castilho RM, Williams VP, Gutkind JS. Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9017-22. Epub 2006 Jun 5. PubMed PMID: 16754882; PubMed Central PMCID: PMC1482558.

Castilho RM, Squarize CH, Nunes FD, Pinto DS Jr. Osteolipoma: a rare lesion in the oral cavity. Br Jf Oral Maxillofac Surg. 2004 Aug; 42(4): 363-4. PubMed PMID: 15225961.

Squarize CH, Castilho RM, Pinto DS Jr. Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. J Oral Pathol Med. 2002 Aug; 31(7): 379-84. PubMed PMID: 12224530.

Book Chapters

Squarize CH, Castilho RM, Leopoldino AM. Drug Target Validation. Current Methods in Medicinal Chemistry and Biological Physics Vol. 2. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 167-186, 2008.

Squarize CH, Castilho RM. Emerging animal models. In Current Methods in Medicinal Chemistry and Biological Physics. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 207-226, 2007.

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