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Periodontics and Oral Medicine

Darnell Kaigler, Jr., DDS, PhD

Assistant Professor

Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave Rm 3310
Ann Arbor, MI 48109-1078

Kaigler Lab
Recent Publications



Completed his DDS in 2001 and in 2004, earned a PhD in Oral Health Sciences (David Mooney, advisor). Dr. Kaigler subsequently earned a certificate in Operative Dentistry, followed by an MS in Clinical Research Design and Statistical Analysis and a Post-doctoral Fellowship through the School's NIDCR Tissue Engineering Training Program at the Clinical Research Core (formerly known as MCOHR).


Certificate in Periodontology from University of Michigan
Board Certified from the American Board of Periodontology

Research Interests

Research focuses on cell-based therapies for alveolar bone tissue engineering applications.

Recent Publications

Kaigler D, Pagni G, Park CH, Braun T, Holman LA, Yi E, Tarle SA, Bartel RL, Giannobile WV.  Stem cell therapy for craniofacial bone regeneration: A randomized, controlled, feasibility trial. Cell Transplant. 2012 Jul 5. (Epub ahead of print)

Kaigler D, Silva EA, Mooney DJ. Guided bone regeneration utilizing injectable VEGF delivery gel. J Periodontol. 2012 Jun 5. (Epub ahead of print)

Kaigler D, Avila G, Wisner-Lynch L, Nevins ML, Nevins M, Rasperini G, Lynch SE, Giannobile WV.  Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration. Expert Opin Biol Ther. 2011 Mar;11(3):375-85.

Tarle SA, Shi S, Kaigler D.  Development of a serum-free system to expand dental-derived stem cells: PDLSCs and SHEDs. J Cell Physiol. 2011 Jan; 226 (1)66-73.

Kaigler D, Pagni G, Park CH, Tarle S, Bartel R, Giannobile WV. Angiogenic and Osteogenic Potential of Bone Repair Cells for Craniofacial Regeneration. Tissue Eng Part A. 2010 Apr 22. [Epub ahead of print]. PMID: 20412009.

Kaigler D, Cirelli JA, Giannobile WV. Growth factor delivery for oral and periodontal tissue engineering. Expert Opin Drug Deliv. 2006 Sep;3(5):647-62. Review. PubMed PMID: 16948560; PubMed Central PMCID: PMC2573469.

Kaigler D, Krebsbach PH, Wang Z, West ER, Horger K, Mooney DJ. Transplanted endothelial cells enhance orthotopic bone regeneration. J Dent Res. 2006 Jul;85(7):633-7. PubMed PMID: 16798864.

Ennett AB, Kaigler D, Mooney DJ. Temporally regulated delivery of VEGF in vitro and in vivo. J Biomed Mater Res A. 2006 Oct;79(1):176-84. PubMed PMID: 16788907.

Kaigler D, Wang Z, Horger K, Mooney DJ, Krebsbach PH. VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res. 2006 May;21(5):735-44. PubMed PMID: 16734388.

Leach JK, Kaigler D, Wang Z, Krebsbach PH, Mooney DJ. Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials. 2006 Jun;27(17):3249-55. Epub 2006 Feb 21. PubMed PMID: 16490250.

Kaigler D, Krebsbach PH, West ER, Horger K, Huang YC, Mooney DJ. Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB J. 2005 Apr;19(6):665-7. Epub 2005 Jan 27. PubMed PMID: 15677693.

Huang YC, Simmons C, Kaigler D, Rice KG, Mooney DJ. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther. 2005 Mar;12(5):418-26. PubMed PMID: 15647766.

Huang YC, Kaigler D, Rice KG, Krebsbach PH, Mooney DJ. Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res. 2005 May;20(5):848-57. Epub 2004 Dec 20. PubMed PMID: 15824858.

Kong HJ, Kaigler D, Kim K, Mooney DJ. Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution. Biomacromolecules. 2004 Sep-Oct;5(5):1720-7. PubMed PMID: 15360280.

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