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Lab Director:
Jian-Guo Geng, MD, PhD |
POSTDOCTORAL POSITION AVAILABLE |
Research Activity:
Adhesion and migration of mammalian cells are of crucial importance in a number of biological events, such as fertilization, embryogenesis, pattern, tissue and organ formation, and in a variety of physiological and pathological processes, including lymphocyte trafficking, leukocyte recruitment, hemostasis, wound healing, tumor angiogenesis and cancer metastasis. My research has been focused on cell adhesion and migration of leukocytes, platelets, endothelial cells and tumor cells for their functional roles in inflammation, thrombosis and cancer growth and metastasis. We are particularly interested in identifying molecular targets critical in the pathogeneses of these diseases, elucidating the structure-function relationships of newly identified protein-protein interactions, and searching for small molecular weight modulators for treating inflammation, thrombosis and carcinogenesis. Additionally, we are studying adhesion and migration of cranial neural crest cells during early craniofacial development.