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Biologic and Materials Sciences and Division of Prosthodontics

Drach Lab Recent Publications

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Review Chapter

Biron, K.K., K.S. Gudmundsson and J.C. Drach.  Benzimidazole ribonucleosides:  Novel drug candidates for the prevention and treatment of cytomegalovirus diseases.  In “Antiviral Drugs: From Basic Discovery Through Clinical Trials”; ed. by W.M. Kazmierski, John Wiley & Sons, Inc., Hoboken, NJ, 2011, pp. 417-433.


Original Research Publications

Zhou, S., J.C. Drach, M.N. Prichardand J. Zemlicka.  (Z)- and (E)-2-(1,2-Dihydroxyethyl)methylene-cyclopropane Analogues of 2´-Deoxyadenosine and 2´-Deoxyguanosine.  Synthesis of All Stereoisomers, Absolute Configuration and Antiviral Activity.  J. Med. Chem. 52: 3397-3407, 2009.

Li, C., B.G. Gentry, J.C. Drach, and J. Zemlicka.Synthesis and Enantioselectivity of Cyclopropavir Phosphates for Cellular GMP Kinase.  Nucleosides, Nucleotides, & Nucleic Acids 28: 795-808, 2009.

Wu, Z., J.C. Drach, M.N. Prichard, M. Yanachkova, I. Yanachkov, T.L. Bowlin, and J. Zemlicka.  L-Valine ester of cyclopropavir: a new antiviral prodrug.  Antiviral Chem. & Chemother. 20: 37-46, 2009.

Hwang, J.-S., R. Schilf, J.C. Drach, L.B. Townsend,and E. Bogner.  Susceptibilities of HCMV clinical isolates and other herpesviruses to new acetylated, tetrahalogenated benzimidazole D-ribonucleosides.  Antimicrob. Agents Chemother., 53: 5095–5101 2009.

Ptak, R.G., B.G. Gentry, T.L. Hartman, K.M. Watson, M.C. Osterling, R.W. Buckheit, Jr., L.B. Townsend and J.C. Drach.  Inhibition of Human Immunodeficiency Virus Type 1 by Triciribine Involves the Accessory Protein Nef.  Antimicrob. Agents Chemother., 54: 1512-1519, 2010.

Selvam, P., J.M. Breitenbach, K.Z. Borysko, and J.C. Drach.  Synthesis, antiviral activity, and cytotoxicity of some novel 2-phenyl-3-disubstituted quinazolin-4(3h)-ones.  Internat. J. Drug Design & Discovery, 1: 149-154, 2010.

Gentry, B.J., J.P. Kamil, D.M. Coen, J. Zemlicka, and J.C. Drach.  Stereoselective Phosphorylation of Cyclopropavirby pUL97 and CompetitiveInhibition by Maribavir. Antimicrob. Agents Chemother., 54: 3093–3098,2010.

Selvam, P., J.M. Breitenbach, K.Z. Borysko, and J.C. Drach.  Synthesis, Anti-HSV Activity, and Cytotoxicity of leaf extract ofmorinda citrifoliaNoni Journal of Clinical Res., 1:2-,2010.

Gentry, B.G., S.N. Gentry, T.L. Jackson, J. Zemlicka, and J.C. Drach.  Phosphorylationof Antiviral and Endogenous Nucleotides to Di- and Triphosphates by Guanosine Monophosphate Kinase.  Biochem. Pharmacol., 81: 43–49, 2011.

Prichard, M.N., S.L. Frederick, S. Daily, K.Z. Borysko, L.B. Townsend, J.C. Drach, and E.R. Kern.  Benzimidazole Analogs Inhibit Human Herpesvirus 6.  Antimicrob. Agents Chemother., 55: 2442–2445, 2011.

Peterson, L.W., J.-S. Kim, P. Kijek, S. Mitchell, J.M. Hilfinger, J.M. Breitenbach, K.Z. Borysko, J.C. Drach, B.A. Kashemirov, and C.E. McKenna.  Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.  Bioorg. & Med. Chem. Lttrs., 21: 4045-4049, 2011.

Zakharova, V.M., M. Serpi, I.S. Krylov, L.W. Peterson, J.M. Breitenbach, K.Z. Borysko, J.C. Drach, M. Collins,J.M. Hilfinger, B.A. Kashemirov, and C.E. McKenna.  Tyrosine-Based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) Prodrugs: Synthesis, Stability, Antiviral Activity and in Vivo Transport Studies. J. Med. Chem. 54: 5680-5693, 2011.


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