The final course in the series of “diagnostic sciences” courses, will focus on more detailed topics in the broad area of oral and maxillofacial pathology/radiology and clinical oral pathology/oral medicine and will build on the foundation of material covered in Diagnostic Sciences I (DENT 526; describing and identify the most common clinical and radiographic lesions), Diagnostic Sciences II (DENT 623A; radiographic presentation), “Neoplasia: General Concepts and Oral Cancer” (DENT 605; The Patient with Neoplasia), and Diagnostic Sciences III (DENT 623B, overview of soft tissue and bone pathology with an emphasis on clinical-radiographic- pathologic correlation). This course also builds on the material covered in previous courses in anatomy, histology, diagnosis and treatment planning, general pathology, pharmacology, therapeutics, and oral surgery. Students are expected to have a solid grasp of the pertinent material covered in previous classes in order to be able to participate successfully in this course. This course is designed to assist third-year dental students with integrating their previously attained knowledge and clinical skills to formulate an appropriate diagnosis and management plan for patients with both simple and complex oral and maxillofacial conditions that are likely to be encountered in clinical practice.