Currently Enrolling Clinical Studies  

The Impact of Parathyroid Hormone (PTH) on Craniofacial Osseous Regeneration in Bone

The Michigan Center for Oral Health Reseach (MCOHR) is seeking volunteers for a dental implant study.  Eligible participants will receive an implant and crown at no charge to replace a missing tooth in the lower jaw.

Volunteers must meet the following initial criteria:

• Ages 30-85
• Missing lower back tooth (premolar or molar)
• Tooth extracted at least 12 months prior to screening
• No Liver or Kidney disease (incl. history of kidney stones)
• No Heavy smokers
• No Uncontrolled diabetes
• No Allergy to tetracycline

For more information please call or email:
Email: mcohrclinicalresearch@umich.edu
Phone: (734) 998-6721

 Biomarkers of Periodontal Disease Progression

The Michigan Center for Oral Health Research (MCOHR) is seeking volunteers to take part in a clinical research study. The purpose of this study is to find out which germs make gum disease worse.

The study requires you to come to our clinic for up to 14 visits.

To qualify, you must:

• Be at least 25 years old
• Have at least 20 natural teeth
• Have not used tobacco products for at least a year
• Be willing to delay dental cleanings for one year

Those who participate in this study will be paid for their participation. At the end of the study participants will receive a full dental cleaning.

For more information please call or email:
Email: mcohrclinicalresearch@umich.edu
Phone: (734) 998-6721
 

Periostin and Gum Disease study

 The Michigan Center for Oral Health Research (MCOHR) is seeking volunteers to take part in a clinical research study to evaluate levels of a protein called Periostin.  

Major Inclusion Criteria:

• Aged at least 21 years
• In need of periodontal surgery (i.e. flap surgery, gingivectomy, crown lengthening)
• Periodontal (gum) disease OR healthy gums 
• Must be a non-smoker for at least 12 months
• Overall good health

Eligible participants will receive periodontal surgery at no charge.

For more information please call or email:
Email: mcohrclinicalresearch@umich.edu
Phone: (734) 998 - 6721  

 

Volunteers are needed for a clinical research study evaluating how a patient's own bone cells can help regenerate (grow) bone in the area of your jaw where there is not enough supporting bone for implant placement. This process is called Bone Repair Cell (BRC) Therapy.

Volunteers must meet the following major inclusion criteria:

• Between the ages of 20 - 70
• In need of a sinus floor bone graft in upper jaw and dental implant
• Must be a non-smoker for at least 6 months
• Overall good health

• Have a Body Mass Index or BMI appropriate for bone marrow aspiration (Less than or equal to 25.9)

Eligible participants will receive bone graft, dental implant, and implant restoration (crown) at no charge.

For more information please call or email:
Email: mcohrclinicalresearch@umich.edu
Phone: (734) 998 - 6721 

Recruitment Complete!!!

Volunteers are needed for a clinical research study using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging in people who get migraine headaches, and in healthy controls to identify factors that may be correlated with the severity of migraine attacks.

Volunteers must meet the following major inclusion criteria:

• Between the ages of 18 - 45
• Males or females
• Between 1 and 14 migraine attacks per month OR Healthy patients not experiencing migraines
• No history of other neurologic, systemic disorders, or chronic pain

Participation will involve:

• Up to 3 brain scans, approximately 1 - 3.5 hours each

Eligible participants will receive $25 per half hour, and transportation may be provided.

For more information please call or email:
(734) 615 - 9390
Email: contactHOPE@umich.edu

Volunteers are needed for a 2-month research study using Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET) imaging, as well as non-invasive brain stimulation (tDCS) in people who suffer from chronic trigeminal neuropathic pain (TNP), and in healthy controls to identify factors that may be associated with chronic pain in patients with TNP.

Volunteers must meet the following major inclusion criteria:

• Between the ages of 18 - 65
• Good general health
• Suffer from daily chronic trigeminal neuropathic pain (TNP) for at least 6 months OR Healthy patients not experiencing TNP
• Unilateral pain

Participation will involve:

• 1 MRI scan, approximately 2 hours each
• 2 PET scans with tDCS sessions, approximately 2 hours each

Eligible participants will receive $25 per half hour.

For more information please call or email:
(734) 615 - 9390
Email: contactHOPE@umich.edu

Recruitment Complete!!!

Volunteers WITH RHEUMATOID ARTHRITIS that have both HEALTHY gums or those WITH GUM DISEASE are needed for a Periodontal (Gum) Disease study. This study involves collection of blood and plaque samples for measuring proteins linked to gum disease.

Major Inclusion Criteria:

• Age 35 and older
• Must have at least 20 permanent teeth
• Healthy gums or severe gum disease 
• Patients WITH Rheumatoid Arthritis
• Must not be pregnant
• Must not have had periodontal treatment(s) in the last 12 months

Eligible participants will receive teeth cleaning and xrays at no charge.

For more information please call or email:
Email: mcohrclinicalresearch@umich.edu
Phone: (734) 998 - 6721  

Oral Health and Breast Cancer Survivors on Aromatase Inhibitors Study

Post-menopausal women with and without breast cancer are needed for an Oral Health Quality of Life study.

Major inclusion criteria:

• Post-menopausal females with and without breast cancer
• Must have at least 15 permanent teeth
• Women with breast cancer taking an aromatase inhibitor (Arimidex, Aromasin, or Femara) for less than 1 year

During the study you will:

• Visit the Michigan Center for Oral Health Research located at Domino's Farms for 1 visit
• Have a dental examination, including a sample of saliva and blood, and complete a survey
• Spend 2 - 3 hours per visit

Participants will receive $40 for completing the study

For more information please call or email:
(734) 764 - 5502
Email: oralhealthbreastcancer@umich.edu

If you do not see a study that fulfills your needs, please go the Patient Care home page to find more information about becoming a patient at the University of Michigan School of Dentistry!

MCOHR
General Phone: (734) 998 - 1468
Patient Phone: (734) 998 - 6721
Fax: (734) 998 - 6900
24 Frank Lloyd Wright Dr.
Lobby M, Box 422
Ann Arbor, MI 48106
mcohrclinicalresearch@umich.edu

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