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Nisha Jacinta D'Silva, BDS, MSD, PhD
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Donald A. Kerr Endowed Collegiate Professor of Oral Pathology
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Nisha Jacinta D'Silva, BDS, MSD, PhD
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Donald A. Kerr Endowed Collegiate Professor of Oral Pathology
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Education
| 1987 | BDS (DDS), Dentistry, University of Bombay, India |
| 1990 | MSD, Oral and Maxillofacial Pathology, Indiana University, Indianapolis, IN |
| 1997 | PhD, University of Washington, Seattle, WA |
| 1998 | Certificate, Fellowship in Dental Education in the Care of the Disabled, University of Washington, Seattle, WA |
Certification and Licensure
| 1987 to 1990 | Certificate in Oral and Maxillofacial Pathology, Minor in Oral Radiology |
| 1992 | National Board Dental Examinations |
| 1992 to present | Fellow of the American Academy of Oral and Maxillofacial Pathology |
| 1993 to present | Diplomate of the American Board of Oral and Maxillofacial Pathology |
| 1997 to present | Dental License, State of Washington |
| 1998 | Fellowship (didactic and clinical) in Dentistry for persons with disabilities |
| 1999 to present | Dental License, State of Michigan |
Academic, Administrative and Clinical Appointments
| 1987 to 1990 | Associate Instructor, General Pathology Laboratory, Indiana University, Indianapolis, IN |
| 1994 to 1998 | Acting Instructor, Department of Oral Biology, University of Washington, Seattle, WA |
| 1998 to 2007 | **Assistant Professor, Department of Oral Medicine/Pathology/Oncology, University of Michigan, Ann Arbor, MI |
| 1999 to 2000 | Clinic Attending, Oral Medicine Clinic, University of Michigan |
| 2000 to 2003 | May through August annually - Interim Director, Oral and Maxillofacial Pathology Biopsy Service, University of Michigan |
| 2002 to 2007 | Director, Head and Neck Cancer Tissue Core, University of Michigan Cancer Center |
| 2004 to 2008 | Director, Oral and Maxillofacial Pathology Biopsy Service, University of Michigan School of Dentistry |
| 2006 to present | Assistant Professor, Department of Pathology, University of Michigan Medical School |
| 2007 to present | Associate Professor with tenure, Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI |
| 2007 to present | Donald Kerr Endowed collegiate professor of Oral Pathology, University of Michigan, Ann Arbor, MI |
| 2008 to present | Associate Chair, Division of Oral Pathology/Medicine/Radiology |
| ** Department of Oral Medicine/Pathology/Oncology merged with Periodontics and Oral Medicine in September, 2005 |
Honors and Awards
| 1982 to 1983 | College Union Committee Scholarship for the best All-Round Student of Sophia (Junior) College |
| 1982 to 1987 | Sir Dorab Tata Scholarship for excellence in academic and extra-curricular activities, awarded annually (City award, Bombay) |
| 1983 to 1984 | St. Luke s Medical Guild Scholarship |
| 1987 | J. N. Tata Scholarship, (National award - India) |
| 1987 | J. R. D. Sethna Scholarship, (City award, Bombay) |
| 1987 | Shri Brihad Bharatiya Samaj Scholarship |
| 1993 to 1994 | Warren G. Magnuson Scholarship for academic excellence and potential for contribution to research, University of Washington, first recipient |
| 1996 | American Association for Dental Research Edward H. Hatton award winner |
| 1996 | International Association for Dental Research Edward H. Hatton award winner |
| 2001 | Special Dean's Award for Research, University of Michigan |
| 2002 | Special Dean's Award for Research, University of Michign |
| 2004 | Selected for faculty membership of Omicron Kappa Upsilon, Chi Chapter, Dental Honorary Society |
| 2005 to 2006 | Selected for ADEA leadership institute; 21 dental faculty selected nationwide |
| 2006 | Crosby Award (NSF-funded ADVANCE program) for women in science and engineering |
| 2007 to present | Donald Kerr Endowed Collegiate Professor, University of Michigan |
Research Interests
1) Rap1 studies. We have investigated the role of rap1, a small GTP-binding protein in development and progression of head and neck cancer. We are continuing these studies with a recently funded R01 grant (NIH funded) that focuses on the role of rap1 in integrating the loss of cell adhesion with cell invasion and migration in keratinocytes.
2) Early Detection studies. Head and neck cancer has a 5 year survival rate of less than 50%, primarily due to late detection. In a collaborative project with Dr. Arul Chinnaiyan, Professor of Pathology, we are profiling the immune response to head and neck cancer with the notion that these antibodies will form the basis of a serum-based early detection assay for head and neck cancer. We recently received and R21 grant (NIH funded) to continue these studies.
3) Biomarkers for treatment selection. Our exploratory studies in the early detection project, revealed possible biomarkers for prediction of treatment response in head and neck cancer. We have applied for internal funding to generate more preliminary data and plan to submit an R01 grant application in June 2009.
Selected Recent Publications
Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D'Silva NJ. Galanin Receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. J Biological Chemistry 280(24):22564-71, 2005. PMID: 15767248
Cordell KG, Stannard S, D'Silva NJ. AAOMP case challenge: "Erythematous burning lips". J Contemp Dent Pract. 1;7(2):160, 2006. PMID: 16685308
D'Silva NJ, Cordell KG, Flint A, Allen CM, Machiorlatti K, Zietz L. Odontogenic Sarcoma with Smooth Muscle Differentiation: Report of a case and Review of the Literature. Oral Oncology Extra, 2006; 42: 273-276.
Zhang L, Chenwei L, Mahmood R, van Golen K, Greenson J, Li G, D'Silva NJ, Li X, Burant CF, Logsdon C, and Simeone DM. Identification of a putative tumor suppressor gene rap1GAP in pancreatic cancer. Cancer Res. 66(2):898-906, 2006. PMID: 16424023
Zhang Z, Mitra R, Henson B, Datta N, McCauley L, Kumar P, Lee J, Carey T and D'Silva NJ. Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Am J Pathol. 168(2):585-96, 2006. PMID: 16436672
Wolter KG, Wang, SJ, Henson B, Wang S, Griffith KA, Kumar B, Chen J, Carey TE, Bradford CR, D'Silva NJ. (-)-Gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia 2006 Mar 8(3):163-172. PMID: 16611409
D'Silva NJ, Summerlin D-J, Cordell KG, Abdelsayed RA, Tomich CE, Hanks CT, Fear D, Meyrowitz S. Metastatic Tumors to the Jaws: Retrospective Study of 114 cases. J Am Dent Assoc. 2006 Dec;137(12):1667-72. PMID: 17138711
Kirkwood KL, Li F, Rogers JE, Otremba J, Coatney DD, Kreider JM, D'Silva NJ, Chakravarty S, Dugar S, Protter AA, and Medicherla S. A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss. J Pharmacol Exp Ther. 2007 Jan;320(1):56-63. PMID: 17041006
Chiou S, Gobetti JP, D'Silva NJ. Mucous Membrane Pemphigoid: A retrospective study. Michigan Dental Journal, 2007, 89:46-52. PMID: 17564340
Henson B, Li F, Coatney DD, Carey TE, Mitra RS, Kirkwood KL, and D'Silva NJ. An orthotopic floor-of mouth model for loco-regional growth and spread of human squamous cell carcinoma. Journal of Oral Pathology and Medicine 2007, July 36(6): 363-70. PMID: 17559499
Bauer JA, Kumar B , Cordell KG , Prince ME, Tran HH, Wolf GT, Chepeha D, Teknos T, Wang S, Eisbruch A, Tsien C, Urba SG, Worden FP, Lee JS, Griffith K, Taylor J, D'Silva NJ, Wang S, Wolter K, Henson B, Fisher S, Carey T, Bradford CR. Targeting Apoptosis to Overcome Cisplatin Resistance: A Translational Study in Head and Neck Cancer. Int. Journal of Radiation Oncology, Biology, Physics, 2007, 69:S106-8. PMID: 17848273
Kumar B , Cordell KG , Lee JS, Prince ME, Tran HH, Wolf GT, Urba SG, Worden FP, Chepeha D, Teknos T, Eisbruch A, Tsien C, Taylor J, D'Silva NJ, Yang K, Kurnit DM, Bradford CR, Carey T. Response to Therapy and Outcome in Oropharyngeal Cancer Are Predicted by Biomarkers Including HPV, EGFR, Gender and Smoking. Int. Journal of Radiation Oncology, Biology, Physics. 2007, 69:S109-11. PMID: 17848274
D'Silva NJ, Benian R, Flint A, Cordell KG. Soft tissue swelling of the upper lip. Oral Surg, Oral Med, Oral Pathol, Oral Radiol, Endod 2008 Mar;105(3):271-3. PMID: 18280958
Kumar B, Cordell K, Lee JS, Worden FP, Prince ME, Tran HH, Wolf GT, Urba SG, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor J, D'Silva NJ, Yang K, Kurnit D, Bauer J, Bradford C, Carey T. EGFR, p16, HPV Titer, BCLXL and p53, Gender and Smoking as Indicators of Response to Therapy and Survival in Oropharyngeal Cancer. In Press. J Clin Oncology, 2008.
Worden F, Kumar B, Lee JS, Wolf GT, Cordell K, Taylor J, Urba S, Eisbruch A, Teknos T, Chepeha D, Prince M, Tsien C, D'Silva NJ, Yang K, Kurnit D, Mason H, Miller T, Wallace N, Bradford C, Carey T. Chemoselection as a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated with HPV16 Copy Number. In Press. J Clin Oncology, 2008.
Cudney N, Persico J, Cordell KG, D'Silva NJ. Adenomatoid odontogenic tumor developing in association with an odontoma: Report of a case. In Press. Quintessance International, 2008.
Chiu E, Havens AM, Taba Jr, Wang MJ, Sun YX, Jung YH, Taichman SL, D'Silva NJ, Gopalakrishnan R, Wang CY., Giannobile WV, Taichman RS. Stromal Derived Factor-1a (CXCL12) Levels Increase During Periodontal Disease. In Press. J Perio, 2008.
Kumar B, Cordell K, D'Silva NJ, Prince ME, Adams ME, Fisher SG, Wolf GT, Carey TE, Bradford C. Expression of p53 and Bcl-xL as Predictive Markers for Larynx Preservation in Advanced Laryngeal Cancer. Arch Otolaryngol Head Neck Surg. 2008 Apr;134(4):363-9. PMID: 18427001
Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JMG, Pan Q, Carey TE, Bradford CR, Prince ME, Cordell K, Kirkwood KL and D'Silva NJ. Rap1GAP promotes invasion via induction of MMP-9 secretion, which is associated with poor survival in early N-stage squamous cell carcinoma. Cancer Research, In Press, 2008.
Last updated: May 2008