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Laurie K. McCauley, DDS, MS, PhD
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The William K. and Mary Anne Najjar
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Laurie K. McCauley, DDS, MS, PhD
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The William K. and Mary Anne Najjar
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Education
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BS, Education, The Ohio State University, 1980 |
Honors and Awards
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Elected Fellow, American Association for the Advancement of Science, to be honored during AAAS annual meeting, 2008 |
Academic Appointments and Professional Experience
| 1984-1985 | Student Teaching Assistant, College of Dentistry, The Ohio State University |
| 1985-1988 | Graduate Teaching Assistant, Department of Periodontology, College of Dentistry, The Ohio State University |
| 1988-1991 | Private practice limited to Periodontics, Marysville, Ohio |
| 1988-1991 | Graduate Research Fellow, Department of Periodontology, College of Dentistry, The Ohio State University |
| 1988-1991 | Graduate Research Fellow, Department of Veterinary Pathobiology, The Ohio State University |
| 1992-1996 | Assistant Professor, Department of Periodontics/Prevention/Geriatrics, University of Michigan |
| 1996-2001 | Associate Professor, Department of Periodontics and Oral Medicine, University of Michigan |
| 1996-2002 | Director, Center for Biorestoration of Oral Health |
| 1992-present | Private practice limited to Periodontics, Dental Faculty Associates, University of Michigan |
| 1998-1999 | Visiting Scientist, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Strasbourg France, Hosted by Professor and Director, Pierre Chambon |
| 2001-present | Associate Professor, Department of Pathology, Medical School, University of Michigan |
| 2001-present | Professor, Department of Periodontics and Oral Medicine (formerly Periodontics/Prevention/Geriatrics), University of Michigan, Ann Arbor, MI |
| 2002-present | Chair, Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI |
| 2002-present |
William K. and Mary Anne Najjar Professor of Periodontics |
| 2005-2006 | Visiting Scientist, Ecole Normale Supérieure, Lyon France, Hosted by Professor Pierre Jurdic |
Research Interests
Current research areas are hormonal controls of bone remodeling. Anabolic actions of parathyroid hormone (PTH), parathyroid hormone-related protein (PTHrP) and their dependence on the PTH-1 receptor and AP-1 transcription factors to evoke their anabolic actions. The role of PTHrP in skeletal specific processes such as bone metastasis and tooth eruption. The dependence of sex steroids on actions of parathyroid hormones in bone.
Selected Recent Publications
Datta NS, Pettway GJ, Chen C, Koh AJ, McCauley LK. Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells. J Bone Miner Res 22:951-64, 2007.
Berry JE, Ealba E, Pettway GJ, Datta N, Swanson E, Somerman MJ, McCauley LK. JunB as a mediator of the PTHrP actions in cementoblasts. J Bone Miner Res 21:246-257, 2006.
Jung Y, Wang J, Schneider A, Sun YX, Koh AJ, Osman NI, McCauley LK, Taichman RS. Regulation of SDF-1(CXCL12) production by osteoblasts in the hematopoietic microenvironment and a possible mechanism for stem cell homing. Bone 38:497-508, 2006.
Liao J, Schneider A, Datta NS, McCauley LK. Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis. J Cancer Res 66:9065-9073, 2006.
Padbury AD, Tozum TF, Taba M, Ealba EL, West B, Burney RE, Gauger PG, Giannobile WV, McCauley LK. The impact of primary hyperparathyroidism on the oral cavity. J Clin Endocrinol Metab 91:3439-45, 2006.
Somerman MJ, McCauley LK. Bisphosphonates: sacrificing the jaw to save the skeleton? BoneKEy-Osteovision. IBMS 3(9):12-18, 2006.
Yamashita J, McCauley LK. The activating protein-1 transcriptional complex: Essential and multifaceted roles in bone. Clin Reviews Bone Mineral Metab 4:107-122, 2006.
Zhang Z, Mitra RS, Henson BS, Datta NS, McCauley LK, Kumar P, Lee JS, Carey TE, D’Silva NJ. Rap1 Gap Inhibits Tumor Growth in Oropharyngeal Squamous Cell Carcinoma. Am J Pathology 168:585-596, 2006.
Datta NS, Chen C, Berry JE, McCauley LK. PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest. J Bone Miner Res 20:1051-64, 2005.
Koh AJ, Demiralp B, Neiva K, Hooten J, Nohutcu RM, Shim H, Datta NS, Taichman RS, McCauley LK. Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology 146:4584-4596, 2005.
Pettway GJ, Schneider A, Koh AJ, Widjaja E, Morris MD, Meganck JA, Goldstein SA, McCauley LK. Anabolic actions of PTH (1-34): Use of a novel tissue engineering model to investigate temporal effects on bone. Bone 36:959-970, 2005.
Schneider A, Kalikin LM, Mattos AC, Keller ET, Allen MJ, Pienta KJ, McCauley LK. Bone turnover mediates preferential localization of prostate cancer in the skeleton. Endocrinology 146:1727-1736, 2005.
Sun YX, Schneider A, Jung JH, Wang J, Dai J, Wang K, Cook K, Ishag-Osman NI, Liang Z, Koh AJ, Shim H, Pienta K, Kleer ET, McCauley LK, Taichman RS. Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. J Bone Miner Res 20:318-29, 2005.
Last updated: July 30, 2007