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Yvonne Kapila, DDS, PhD
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Associate Professor Department of Periodontics and Oral Medicine Dr. Kapila Research Interests & Lab |
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Education
| 1997-98 | Cell Biology, Postdoctorate, Stanford University, Stanford CA |
| 1997 |
PhD, Oral Biology, University of California, San Francisco CA |
| 1994 | Certificate, Periodontology, University of California, San Francisco CA |
| 1990 | DDS, BS, Dentistry, University of California, San Francisco CA |
| 1986 | BA, Human Biology, Stanford University, Stanford CA |
Professional Experience
| 2004-present | Associate Professor, Department of Periodontics/Prevention/Geriatrics, University of Michigan |
| 1999-2004 | Assistant Professor, Department of Stomatology, Division of Periodontology UCSF |
| 1997-1999 | Assistant Adjunct Professor, Department of Stomatology, Division of Periodontology UCSF |
| 1994-1997 | Assistant Research, Department of Stomatology, Division of Periodontology UCSF |
| 1993-1994 | Visiting Assistant Research, Department of Stomatology, UCSF |
| 1991-1994 | Dentist in private practice in San Francisco, one half day per week |
| 1991-1993 | Postgraduate Research, Department of Stomatology, Division of Periodontology, UCSF |
| 1983-1986 | Lab Assistant, Stanford University/VA Hospital (Neuropath Lab Dr. Lawrence Eng) |
Honors
| 2006-present | NIH ODCS Study Section Reviewer-Standing Member |
| 2006 | NIH ODCS Study Section Reviewer- Ad Hoc Member |
| 2000 | UCSF Faculty Development Award |
| 1997 | Winner of the Edward H. Hatton Awards of the American Association for Dental Research |
| 1997 | Winner of the Baliant Orban Research Competition-American Academy of Periodontology |
| 1995 | California Society of Periodontists (CSP) Meeting-Basic Research Award |
| 1993 -1998 | Individual Dentist Scientist Award Grant (K15) |
| 1992, 1993 | Achievement Rewards for College Scientists (ARCS) Scholarship |
| 1991 -1993 | Postgraduate Fellowship, Department of Stomatology, School of Dentistry, UCSF |
| 1990 | UCSF President’s Fellowship for Graduate School |
| 1988 | National Cancer Institute, Clinical Fellow - Oral medicine |
| 1987 | NIH Summer Research Fellowship |
| 1985 | Undergraduate Research Opportunities Firestone Minor Grant at Stanford University |
Selected Publications
Y L. Hernandez and Troy E. Daniels. 1988. Oral candidiasis in Sjogren's syndrome: Prevalence and clinical correlations. UCSF Dental Explorer, 2: 22-24.
Y L. Hernandez and Troy E. Daniels. 1989. Oral candidiasis in Sjogren's syndrome: Prevalence, clinical correlations, and treatment. Oral Surgery, Oral Medicine, and Oral Pathology, 68:324-329.
Y. Kapila, S. D. Kapila, P. W. Johnson. 1996. Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biology, 15:251-261.
Y. Kapila, H. Kashani. 1997. Cocaine-associated rapid gingival recession and dental erosion. A case report. Journal of Periodontology.68:485-488.
Y. Kapila, J. J. Niu, P. W. Johnson. 1997. The high-affinity heparin-binding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro. Journal of Biological Chemistry. 272:18932-18938.
Y. Kapila, H. Lancero, P.W. Johnson. 1998. The response of periodontal ligament cells to fibronectin. Journal of Periodontology. 69:1008-1019.
Y. L. Kapila, S. Wang, P.W. Johnson. 1999. Mutations in the Heparin-Binding Domain of Fibronectin in Cooperation with the V region Induce Decreases in pp125FAK Levels plus Proteoglycan-mediated Apoptosis via Caspases. Journal of Biological Chemistry. 274: 30906-30913.
B. Hu, Y. Kapila, M. Shiga, S. Kapila. 2000. Coordinate induction of collagenase–1, stromelysin-1, and urokinase plasminogen activator (uPA) by the 120 kDa cell-binding fibronectin fragment in fibrocartilagenous cells: uPA contributes to activation of procollagenase-1. Matrix Biology. 19:657-669.
Y.L. Kapila, D. Doan, E. Tafolla, and R. Fletterick. 2001. Three-dimensional structural analysis of fibronectin heparin-binding domain mutations. Journal of Cellular Biochemistry. 36: 156-161.
Y.L. Kapila, S. Wang, P. Dazin, E. Tafolla, M. Mass. 2002. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. Journal of Biological Chemistry, 277:8482-8491.
Huynh QN, Wang S, Tafolla E, Gansky SA, Kapila S, Armitage GC, Kapila YL. 2002. Specific fibronectin fragments as markers of periodontal disease status. J Periodontol 73, 1105-1114.
M. Shiga, Y.L. Kapila, S. Kapila. 2003. Ascorbic acid specifically induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: modulation of collagenase expression is inversely related to changes in alkaline phosphatase phenotype. Journal of Bone and Mineral Research 18:67-77.
A. Iwama, N. Nishigaki, K. Nakamura, I. Imaizumi, N. Shibata, M. Yamasaki, H. Nakamura, Y. Kameyama, Y. Kapila. 2003. The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes. Journal of Dental Research. 82:322-325.
Y.Zhang, H. Lu, P. Dazin, Y. Kapila. 2004. Functional differences between integrin a4 and integrins a5/av in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin. Experimental Cell Research; 295(1):48-58.
S-W. Jee, S. Wang, Y.L. Kapila. 2004. Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells. Journal of Periodontology; 75:523-530.
H. Lu, D. Jin, Y. Kapila. 2004. Application of Laser Capture Microdissection to Phage Display Peptide Library Screening. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 98:692-697.
Y. Zhang, H. Lu, P. Dazin, Y. Kapila. 2004. Squamous cell carcinoma cell aggregates escape suspension-induced p53-mediated anoikis: fibronectin and integrin av mediate survival signals through focal adhesion kinase. Journal of Biological Chemistry. 279: 48342-48349.
R. Dai, A. Iwama, S. Wang, YL Kapila. 2005. Disease-associated fibronectin fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed. Apoptosis 10:503-12.
E. Tafolla, S Wang, B Wong, J Leong, YL Kapila. 2005. JNK1 and JNK2 Oppositely Regulate p53 in Signaling Linked to Apoptosis Triggered by an Altered Fibronectin Matrix— JNK Links FAK and p53. Journal of Biological Chemistry 280:19992-19999.
T Hayami, Q Zhang, YL Kapila, S Kapila. 2007. Dexamethasone mediates osteoblastic differentiation of human periodontal ligament cells by inhibiting collagenase expression. Bone 40:93-104.
Kamarajan P, YL Kapila. 2007. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis. 12:2221-31.
Dr. Yvonne Kapila Research Lab