Jacques Nör, DDS, MS, PhD

Jacques Nor photographProfessor

Cariology, Restorative Sciences, and Endodontics
School of Dentistry, Room 2309
University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078 
TEL = 734-936-9300
FAX = 734-936-1597
EMAIL = jenor@umich.edu
additional contact information |  Complete CV
Research Lab

Major Responsibilities:

Course Director, DENTED612, Molecular Biology in Clinical Dentistry
Joint Appointment, Otolaryngology (Medical School)
Joint Appointment, Biomedical Engineering (College of Engineering)
Honorary Professor, Oral Biology, University of Birmingham, UK
Member, University of Michigan School of Dentistry Executive Committee
Member, CRSE Department Executive Committee
President Elect, Pulp Biology Regeneration Group (IADR)
Council, Dentistry Section (AAAS)

Dr. Nör received his DDS from the Brazilian Federal University (1985), MS in Pediatric Dentistry (1992) and PhD in Oral Health sciences (1999) from the University of Michigan.
 
Dr. Nör research is on head and neck tumor angiogenesis, and in dental pulp tissue engineering. He served as the principle investigator for NIH grants and is Associate Editor of the Journal of Dental Research.

Description of Research Area(s):

Dr. Nör is focused on the cellular and molecular regulation of tumor angiogenesis.  In addition, his research group has worked on the use of stem cells for the engineering of dental pulps.

Publications:

Recent Publications:

  1. Zeitlin BD, Dong Z, Nör JE.  Responsive angiogenic implanted network (RAIN) drop: a novel angiogenic assay.  Lab Invest (In press).
  2. Liu J, Wang X, Jin Q, Jin T, Chang S, Zhang Z, Czajka-Jakubowsk A, Giannobile WV, Nör JE, Clarkson BH.  The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings. Biomaterials 2012 Apr 5. [Epub ahead of print]
  3. Krishnamurty S, Nör JE.  Head an dneck cancer stem cells. J Dent Res 201 Sep 20 [Epub ahead of print].
  4. Imai A, Zeitlin BD, Visioli F, Dong Z, Kishnamurthy S, Light E, Worden F, Wang S, Nör JE.  Metronomic dosing of BH3 mimetic smal molecule yields robust anti-angiogeic and anti-tumor effects.  Cancer Res 72:716-725, 2012.
  5. Campos M, neiva K, Meyers K, Krishnamurthy S, Nör JE.  endothelial derived factors inhibit anoikis of head and neck cancer stem cells.  Oral Oncol 48:26-42, 2012 (Journal Cover).
  6. Zhang Z, Sant'ana M, Nör JE.  The biology of head an dneck cancer stem cells.  Oral Oncol 48:1-9, 2012.
  7. Conde MC, Nedel F, Campos VF, Smith AJ, Nör JE, Demarco FF, Tarquinio S.  Odontoblastic RNA Stability in Different temperature based protocols for Tooth Storage. Int Endod J 45:266-272, 2012.
  8. Tarquinio S, Zhang Z, Neiva K, Polverini PJ, Nör JE.  Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma. J Oral Pathol Med 41:124-130, 2012.
  9. Yamanaka Y, Kaneko T, Yoshiba K, Kaneko R, Yoshiba N, Shigetani Y, Nör JE, Okiji T.  Expression of angiogenic factors in rat periapical lesions. J Endod 38:313-317, 2012.
  10. Rosa V, DellaBona A, Cavalcanti BN, Nör JE.  Tissue engineering: from research to dental clinics.  Dent Mat 28:341-348, 2012.
  11. Zeitlin BD, Nör JE.  Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule. Curr Top Microbiol Immunol 348:115-137, 2011.
  12. Cassagrande L, Cordeiro MM, Nör SA, Nör JE.  Dental Pulp Stem Cells in Regenerative Dentistry. Odontology 99:1-7, 2011.
  13. Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE. Laser-capture microdissection for Factor VIII-expressing endothelial cells in cancer tissues. Methods Mol Biol 755:395-403, 2011.
  14. Sakai VT, Cordeiro MM, Dong Z, Zhang Z, Zeitlin BD, Nör JE.  Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering.  Adv Dent Res 23:325-332, 2011.
  15. Kim JK, Baker J, Nör JE, Hill EE. mTor Plays an Important Role in Odontoblast Differentiation. J Endod 37:1081-1085, 2011.
  16. Wang J, Chen J, Zhang K, Zhao Y, Nör JE, Wu J. TGF-ß1 regulates the invasive and metastatic potential of mucoepidermoid carcinoma cells. J Oral Patholo Med 2011; 40(10):762-768.
  17. Demarco FF, Conde MCM, Cavalcanti B, Casagrande L, Sakai V, Nör JE. Dental pulp tissue engineering. Braz Dent J 22:3-13, 2011.
  18. Chokechanachaisakul U, Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE. Laser Capture Microdissection in Dentistry. Int J Dent 2011 Jan 13. [Epub ahead of print]
  19. Morelli T, Neiva R, Nevins ML, McGuire MK, Scheyer ET, Oh TJ, Braun TM, Nör JE, Bates D, Giannobile WV.  Angiogenic Markers and Healing of Living Cellular Constructs. J Dent Res 90:456-462, 2011.
  20. Hegen A, Blois A, Tiron CE, Hellesøy M, Micklem DR, Nör JE, Akslen LA, Lorens JB.  Efficient in vivo vascularization of tissue engineering scaffolds. J Tissue Engin Regen Med 5(4):e52-62, 2011.
  21. Rosa V, Botero TM, Nör JE. Regenerative endodontics in light of the stem cell paradigm. Int Dent J 61(Suppl. 1):23-28, 2011.
  22. Zhang R, Cooper P, Smith G, Nör JE, Smith AJ. Angiogenic activity of dentin matrix components. J Endod 37:26-30, 2011.
  23. Telles PD, Machado MA, Sakai VT, Nör JE. Pulp tissue from primary teeth: new source of stem cells. J Appl Oral Sci 19:189-194, 2011.
  24. Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE. endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 70:9969-9978, 2010.
  25. Zhang Z, Neiva K, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Diff 17:499-512, 2010.
  26. Zeitlin BD, Spalding AC, Campos MS, Ashimori N, Dong Z, Wang S, Lawrence TS, Nör JE. Metronomic small molecule inhibitor of Bcl-2 is anti-angiogenic and potentiates the anti-tumor effect of ionizing randiation. Int J Radia Oncol 78:879-887, 2010 (Highlights section).
  27. Giordano RJ, Cardó-Vila M, Salameh A, Anobom CD, Zeitlin BD, Hawke DH, Valente AP, Almeida FC, Nör JE, Sidman RL, Pasqualini R, Arap W. From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway. Proc Natl Acad Sci USA 107:5112-5117, 2010.
  28. Casagrande L, Demarco F, Zhang Z, Araujo FB, Shi S, Nör JE. Dentin-derived BMP2 and odontoblastic differentiation of SHED. J Dent Res 89:603-608, 2010 (Journal Cover).
  29. Sakai VT, Zhang Z, Dong Z, Neiva K, Machado M, Shi S, Santos C, Nör JE.  SHED Differentiate Into Functional Odontoblasts and Endothelium.  J Dent Res 89:791-796, 2010.
  30. Demarco F, Casagrande L, Zhang Z, Dong Z, Tarquinio S, Zeitlin B, Shi S, Smith A, Nör JE. The effects of morphogen and scaffold porogen on the differentiation of dental pulp stem cells. J Endod 36:1805-1811, 2010 (Journal cover).
  31. Botero TM, Son JS, Vodopyanov D, Shelburne CE, Nör JE. MAPK signaling is required for LPS-induced VEGF in pulp stem cells. J Dent Res 89:264-269, 2010 (Journal cover).
  32. Liu J, Jin T, Chang S, Czajka-Jakubowska A, Zhang Z, Nör JE, Clarkson BH. The effect of novel fluorapatite (FA) surfaces on osteoblast-like cell adhesion , growth and mineralization. Tissue Engineering Part A 16:2977-2986, 2010.
  33. Aranha A, Zhang Z, Neiva KG, Costa CA, Hebling J, Nör JE. Hypoxia enhances the angiogenic potential of human dental pulp cells. J Endod 36:1633-1637, 2010.
  34. Kim J, Shukla R, Casagrande L, Nör JE, Baker J, Hill E. Dendrimer-RGD Conjugates Enhance Dental Pulp Cell Differentiation. J Dent Res 89:1433-1438, 2010.
  35. Zeitlin BD, Ellis LM, Nör JE. A new role for the VEGF pathway: inhibition of the VEGFR1/Wnt/B-catenin pathway leads to tumor cell death. Clin Cancer Res 15:7453-7455, 2009.
  36. Doebele RC, Schulze-Hoepfner F, Hong J, Chlenski A, Zeitlin B, Goel K, Gomes S, Liu Y, Abe M, Lingen M, Nör JE, Rosner MR.  A novel interplay between Epac/Rap1 and MEK5/ERK5 regulates thrombospondin production to control angiogenesis. Blood 114:4592-4600, 2009.
  37. Jain H, Nör JE, Jackson T. Quantification of Anti-Bcl-2 Therapy and its Suppression of Tumor Vascularization and inhibition of Tumor Growth. Mol Cancer Ther 8:2926-2936, 2009.
  38. Dong Z, Nör JE. Trnascriptional targeting of tumor endothelial cells for gene therapy. Adv Drug Deliv Rev 61:542-553, 2009 (Journal cover).
  39. Neiva K, Zhang Z, Miyazawa M, Warner K, Karl E, Nör JE. Crosstalk initiated by endothelial cells enhances tumor cell survival and migration via STAT3, Akt, and ERK signaling. Neoplasia 11:583-593, 2009 (Highlighted in the cover).
  40. Ashimori N, Zeitlin BD, Zhang Z, Warner K, Spalding A, Turkienicz IM, Teknos TN, Wang S, Nör JE. TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresss head and neck tumor angiogenesis. Mol Cancer Ther 8:893-903, 2009.
  41. Soden RI, Botero T, Hanks CT, Nör JE. Angiogenic signaling triggered by cariogenic bacteria in pulp cells. J Dent Res 88:835-840, 2009.
  42. Kaneko T, Okiji T, Suda H, Nör JE. Gene expression analysis of immunostained endothelial cells isolated from formaldehyde-fixated paraffin embedded experimentally developed carcinoma tissue using laser capture micordissection - a Technical Report. Histochem Cell Biol 72:908-912, 2009.
  43. Zeitlin BD, Zeitlin IJ, Nör JE. An expanding circle of inhibition: small molecule inhibitors of Bcl-2 as anti-cancer cell and anti-angiogenic agents. J Clin Oncol 26:4180-4188, 2008.

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Updated on 09/18/2012