Clarkson Lab

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Brian Clarkson Photo

Welcome to the Clarkson Lab

 

Brian H. Clarkson, BChD, MS, PhD

Lab Director
bricla@umich.edu

Research Interests

  • Synthesis of fluorapatite crystals
    We are investigating the effect of fluorapatite (FA) crystals synthesized in our laboratory for: use in tooth desensitizing pastes; as an addition to bleaching agents to prevent enamel surface softening and sensitivity; and grown on stainless steel and porcelain crowns as "enamel-like" coatings.
  • Synthesis of fluorapatite coatings for implants
    Cellular and molecular studies are on-going to investigate the effects of the FA crystals grow-on metal surfaces as coatings for implants.  These crystals can also be mixed with suitable matricies and used in alveolar ridge augmentation and repair of boney defects.
  • Use of nano-polymers (dendrimers) for control of wound healing
    We are studying the use of dendrimers (nano artificial proteins) functionalized with; cell attachment sequences, anti-inflammatories, vascular inducing molecules etc. attached to the FA coated implant surfaces to enahance, accelerate and control wound healing and boney integration of implants.
  • "Growing" the crown of a tooth
    Stainless steel crowns coated with the FA crystals on their fitting surfaces are being "filled" with a matrix plus dental pulp stem cells to produce a dentin / enamel complex in the shape of the corwn of a tooth.

Lab Team
Harrison Chang photo

Harrison Chang, BS, MS
Research Lab Speciality
renchang@umich.edu

Jun Liu, MS, PhD
Assistant Research Scientist
junlc@umich.edu

 Jun Liu photo

Recent Publications

  1. Liu J, Jin TC, Chang S, Czajka-Jakubowska A, Clarkson BH.  Adhesion and growth of dental pulp stem cells (DPSCs) on enamel-like fluorapatite (FA) surfaces. J Biomed Mater Res A. 98(3):528-534, 2011.
  2. Liu J, Jin TC, Chang S, Czajka-Jakubowska A, Zhang Z, Nör JE, Clarkson BH.  The effect of novel fluorapatite (FA) surfaces on osteoblast-like cell adhesion, growth and mineralization. Tissue Eng Part A. 16(9):2977-2986, 2010.
  3. Clarkson BH, Roger JM.  Dental Education turned upside down. J Dent Res 89:106-107, 2010.
  4. Czajka-Jakubowska AE, Liu J, Chang SR, Clarkson BH. The effect of the surface characteristics of various substrates on fluorapatite crystal growth, alignment, and spatial orientation. Med Sci Monit 15(6):84-88, 2009.
  5. Al-Jawad M, Fragneto G, Liu J, Chang SR, Clarkson BH. Fibronectin adsorption studied using neutron reflectometry and complementary techniques. European Physical Journal E 30(2):175-179, 2009.
  6. Clarkson BH. Change J Dent Res Jun;87(6):510, 2008.
  7. Clarkson BH. Fluoride - understanding its mechanism of action. Orthodontic Forum 85(4):154-162, 2007.
  8. Czajka-Jakubowska AE, Clarkson BH. Cariology: the future. Invited Review. J Ped Neonatal 32:1-4, 2007.
  9. Chen H, Wood S, Chang SR, Czajka-Jakubowska A, Clarkson BH. Synthesis of fluorapatite (FA) nanorods and surfaces. Pol J Environ Sudies 16(2):279-282, 2007.
  10. Liu J, Jin TC, Chang S, Ritchie HH, Smith AJ, Clarkson BH.  Marix and TGF-beta-related gene expression during human dental pulp cell mineralization. In Vitro Cell Dev Biol Anim Mar-Apr; 43(3-4):120-128, 2007 [Epub 2007 May 22].
  11. Czajka-Jakubowska A, Chen H, Clarkson BH. A new generation of microscope for imaging biological samples. Dental Forum 34(1):9-14, 2006.
  12. Lee L-R, Liu J, Clarkson BH, Lin C-P, Godovikova V, Richie HH. Dentin-pulp comoplex responses to carious lesions. Caries Research 4(3):254-264, 2006.
  13. Chen H, Robinson C, Shore RC, Brookes SJ, Zhang J, Smith DA, Clarkson BH, Kirkham J.  Nanoscale analysis of bone mineral crystals. Nanotech 2006.
  14. Chen H, Tang Z, Liu J, Sun K, Chang SR, Peters M, Mansfield J, Czajka-Jakubowska A, Clarkson BH. Acellular synthesis of a human enamel-like microstructure. Advanced Mater (18):1846-1851, 2006b.
  15. Chen H, Czaika-Jakuboska A, Spencer NJ, Mansfield JF, Robinson C, Clarkon BH.  Effects of systematic fluoride an din vitro fluoride treatment on enamel crystals. J Dent Res 85(11):1042-1045, 2006.
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