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Periodontics and Oral Medicine

William V. Giannobile, DDS, MS, DMSc

William Giannobile photoChair, Department of Periodontics & Oral Medicine
Najjar Endowed Professor of Dentistry
and Biomedical Engineering

Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave, Rm #3397
Ann Arbor, MI 48109-1078

  Giannobile Lab Web Site    |    Recent Publications

Dr. Giannobile is the Najjar Endowed Professor of Dentistry and Biomedical Engineering and Chair of the Department of Periodontics and Oral Medicine at the School of Dentistry.  He received his DDS and an MS in Oral Biology from the University of Missouri.  He later received his certificate in Periodontology and Doctor of Medical Science in Oral Biology from Harvard University.  He subsequently completed postdoctoral training in Molecular Biology at the Dana Farber Cancer Institute and Harvard Medical School.

Dr. Giannobile previously served as a faculty member at Harvard and Forsyth Institute in Boston.  He has published and lectured extensively in the fields of Regenerative Medicine, Tissue Engineering, and Salivary Diagnostics as it relates to periodontal and peri-implant reconstruction.

Dr. Giannobile is an Editor-in-Chief of the Journal of Dental Research and is on the editorial boards of multiple journals. He is a fellow of the American College of Dentists and a Diplomate of the American Board of Periodontology. Dr. Giannobile currently serves as president of the American Academy of Periodontology Foundation.

Dr. Giannobile also serves as a consultant to the National Institutes of Health. To read more about Dr. Giannobile as an NIDCR investigator, please visit the NIDCR website for an article on the future impact of research on periodontal disease.

Recent Publications

Kinney JS, Morelli T, Oh M, Braun TM, Ramseier CA, Sugai JV, Giannobile WV. Crevicular fluid biomarkers and periodontal disease progression. J Clin Periodontol. 2013 Nov 7.

Park CH, Rios HF, Taut AD, Padial-Molina M, Flanagan CL, Pilipchuk SP, Hollister SJ, Giannobile WV. Image-Based, Fiber Guiding Scaffolds: A Platform for Regenerating Tissue Interfaces. Tissue Eng Part C Methods. 2013 Dec 14. [Epub ahead of print]

Scheyer ET, Nevins ML, Neiva R, Cochran DL, Giannobile WV, Woo SB, King WN, Spitznagel JK Jr, Bates D, McGuire MK. Generation of Site-Appropriate Tissue by a Living Cellular Sheet in the Treatment of Mucogingival Defects. J Periodontol. 2013 Sep 26. [Epub ahead of print]

Aljateeli M, Giannobile WV, Wang HL. Locally-delivered antibiotics for management of periodontitis: current understanding. J Mich Dent Assoc. 2013 Jul;95(7):42-7.

Giannobile WV, Kornman KS, Williams RC. Personalized medicine enters dentistry: what might this mean for clinical practice? J Am Dent Assoc. 2013 Aug;144(8):874-6.

Taut AD, Jin Q, Chung JH, Galindo-Moreno P, Yi ES, Sugai JV, Ke HZ, Liu M, Giannobile WV. Sclerostin antibody stimulates bone regeneration after experimental periodontitis. J Bone Miner Res. 2013 Nov;28(11):2347-56.

Jiao Y, Darzi Y, Tawaratsumida K, Marchesan JT, Hasegawa M, Moon H, Chen GY, Núñez G, Giannobile WV, Raes J, Inohara N. Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. Cell Host Microbe. 2013 May 15;13(5):595-601.

Chan HL, Giannobile WV, Eber RM, Simmer JP, Hu JC. Characterization of periodontal structures of enamelin-null mice. J Periodontol. 2014 Jan;85(1):195-203.

Tatarakis N, Kinney JS, Inglehart M, Braun TM, Shelburne C, Lang NP, Giannobile WV, Oh TJ. Clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes. Clin Oral Implants Res. 2013 Feb 27.

Chang PC, Seol YJ, Goldstein SA, Giannobile WV. Determination of the dynamics of healing at the tissue-implant interface by means of microcomputed tomography and functional apparent moduli. Int J Oral Maxillofac Implants. 2013 Jan-Feb;28(1):68-76.

Nevins M, Kao RT, McGuire MK, McClain PK, Hinrichs JE, McAllister BS, Reddy MS, Nevins ML, Genco RJ, Lynch SE, Giannobile WV. Platelet-derived growth factor promotes periodontal regeneration in localized osseous defects: 36-month extension results from a randomized, controlled, double-masked clinical trial. J Periodontol. 2013 Apr;84(4):456-64.

Kaigler D, Pagni G, Park CH, Braun T, Holman LA, Yi E, Tarle SA, Bartel RL, Giannobile WV (2012). Stem Cell Therapy for Craniofacial Bone Regeneration: A Randomized, Controlled, Feasibility Trial. Cell Transplant, e-pub. PMID: 22776413.

Giannobile WV, Joskow RW (2012). Clinical and translational oral health research: Prospects for the future. J Dent Res 91(7):633-6.

Ramseier CA, Rasperini G, Batia S, Giannobile WV (2012). Advanced reconstructive technologies for periodontal tissue repair. Periodontal 2000. 59(1):185-202. PMID: 22507066.

Liu J, Wang X, Jin Q, Jin T, Chang S, Zhang C, Czajka-Jakubowska A, Giannobile WV, Nor JE, Clarkson BH (2012). The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings. Biomaterials 33:5036-46.

Chang PC, Giannobile WV (2012). Functional assessment of dental implant osseointegration. Int J Periodontics Restorative Dent. 32(5):e147-53.

Tonetti MS, Palmer R, Working Group 2* (Member) (2012). Clinical research in implant dentistry: study design, reporting and outcome measures: Consensus report of Working Group 2 of VIII European Workshop on Periodontology. J Clin Periodontol 39 (Suppl):12;73-80.

Lin Z, Rios HF, Park CH, Taut AD, Jin Q, Sugai JV, Robbins PD, Giannobile WV (2012). LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells. Gene Ther. Jan 12. PMID: 22241179.

Liu J, Wang X, Jin Q, Jin T, Chang S, Zhang Z, Czajka-Jakubowski A, Giannobile WV, Nör JE, Clarkson BH (2012). The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings. Biomaterials. 2012 Jul; 33(20):5036-46. Epub 2012 Apr 6.

Nevins, M, Kao RT, McGuire MK, Hinrichs JE, McAllister BS, McClain PK, Nevins ML, Reddy MS, Genco RJ, Lynch SE, Giannobile WV (2012). PDGF promotes periodontal regeneration in localized ossous defects: 36 Month Extension Results from a randomized, controlled, double-masked clinical trial. J Periodontol 83: e-pub 21 May.

Padial-Molina M, Marchesan JT, Taut AD, Giannobile WV, Rios HF (2012). Methods to validate tooth-supporting regenerative therapies. Methods Mol Biol 887:135-48.

Park CH, Rios HF, Jin Q, Sugai JV, Padial-Molina M, Taut AD, Flanagan CL, Hollister SJ, Giannobile WV (2012). Tissue engineering bone-ligament complexes using fiber-guiding scaffolds. Biomaterials. 33(1):137-45. Epub 2011 Oct 10. PMID: 21993234.

Pagni G, Pellegrini G, Giannobile WV, Rasperini G (2012). Postextraction alveolar ridge preservation: biological basis and treatments. Int J Dent. 151030. Epub 2012 Jun 12. PMID: 22737169.

Lee A, Ghaname C, Franco L, Loesche WJ, Kornman KS, Giannobile WV, Kinney JS. Bacterial and Salivary Biomarkers Predict the Gingival Inflammatory Profile (2012). J Periodontol, 83: 79-89.

Pagni G, Kaigler D, Rasperini G, Avila-Ortiz G, Bartel R, Giannobile WV (2012). Bone repair cells for craniofacial regeneration. Adv Drug Deliv Rev. 2012 Mar 10. [Epubahead of print] PMID: 22433781.

McGuire MK, Scheyer ET, Neiva R, Cochran DL, Mellonig JT, Giannobile WV, Bates D (2011). Living Cellular Construct for the Treatment of Mucogingival Defects: Results from a Randomized, Within-patient, Controlled Trial. J Periodontol 82(10):1414-23. PMID: 21513473.

Giannobile WV, Wong DT (2011). Salivary diagnostics: oral health and beyond! J DentRes 90(10):1153-4. PMID: 21917604.

Giannobile WV, McDevitt JT, Niedbala RS, Malamud D (2011). Translational and clinical applications of salivary diagnostics. Adv Dent Res ;23(4):375-80. PMID: 21917748.

Kaigler D, Avila G, Wisner-Lynch LA, Nevins ML, Nevins M, Rasperini G, Lynch SE, Giannobile WV (2011). Platelet-Derived Growth Factor Applications in Periodontal and Peri-Implant Bone Regeneration. Exp Opin Biol Ther, 11:375-85. PMID: 21288185.

Kinney JS, Morelli T, Ramseier C, Herr A, Shelburne C, Rayburn LA, Singh AK, Giannobile WV (2011). Saliva/Pathogen Biomarker Signatures and Periodontal Disease Progression. J Dent Res 90: 752-8. PMID: 21406610.

Brinkmann B, Zhang L, Giannobile WV, Wong DT (2011). Salivary Biomarkers for Periodontal Disease Diagnostics. Exp Opin Medical Diag 5:25-35.

Rios HF, Lin Z, Oh B, Park CH, Giannobile WV (2011). Cell and Gene-Based Therapeutics for Periodontal Regenerative Medicine. J Periodontol 82: 1223-37. PMID: 21284553.

Morelli T, Neiva R, Nevins ML, McGuire MK, Scheyer ET, Oh TJ, Nör JE, Braun TM, Bates D, Giannobile WV (2011). Angiogenic markers and healing of living cellular constructs. J Dent Res 90: 456-462. PMID: 21248359.

Bashutski J, Eber RM, Kinney JS, Benavides E, Maitra S, Braun TM, Giannobile WV,McCauley LK (2011). The impact of vitamin D status on periodontal surgery outcomes. J Dent Res 90: 1007-12.

Lin Z, Rios HF, Sugai JV, Jin Q, Giannobile WV (2011). Gene expression dynamics during bone healing and osseointegration. J Periodontol 82: 1007-17.

Lin Z, Rios HF, Volk SL, Sugai JV, Jin Q, Giannobile WV. Gene Expression Dynamics During Bone Healing and Osseointegration. J Periodontol. 2010 Dec 13. [Epub ahead of print] PubMed PMID: 21142982.

Bashutski JD, Eber RE, Kinney JS, Benavides E, Maitra S, Braun T, Giannobile WV, McCauley LK. Teriparatide and Osseous Regeneration in the Oral Cavity. N Engl J Med 2010. E-published Oct 16 2010. PubMed PMID: 20950166.

Seol YJ, Pellegrini G, Franco LM, Chang PC, Park CH, Giannobile WV. Preclinical methods for the evaluation of periodontal regeneration in vivo. Methods Mol Biol. 2010;666:285-307. PubMed PMID: 20717791.

Kaigler D, Pagni G, Park CH, Tarle S, Bartel R, Giannobile WV. Angiogenic and Osteogenic Potential of Bone Repair Cells for Craniofacial Regeneration. Tissue Eng Part A. 2010 Apr 22. [Epub ahead of print]. PMID: 20412009.

Lin Z, Navarro VP, Kempeinen KM, Franco LM, Jin Q, Sugai JV, Giannobile WV. LMP1 Regulates Periodontal Ligament Progenitor Cell Proliferation and Differentiation. Bone. 2010 Mar 26. [Epub ahead of print] PubMed PMID: 20348040.

Chang PC, Lang NP, Giannobile WV. Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants. Clin Oral Implants Res. 2010 Jan;21(1):1-12. PubMed PMID: 20070743; PubMed Central PMCID:PMC2808201.

Pellegrini G, Seol YJ, Gruber R, Giannobile WV. Pre-clinical Models for Oral and Periodontal Reconstructive Therapies. J Dent Res. 2009 Nov 3. [Epub ahead of print] PubMed PMID: 19887682.

Sweier DG, Shelburne PS, Giannobile WV, Kinney JS, Lopatin DE, Shelburne CE. IgG class, but not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in periodontitis using a fluorescent ELISA. Clin Vaccine Immunol. 2009 Sep 30. [Epub ahead of print] PubMed PMID: 19793900.

Chang PC, Seol YJ, Cirelli JA, Pellegrini G, Jin Q, Franco LM, Goldstein SA, Chandler LA, Sosnowski B, Giannobile WV. PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration. Gene Ther. 2009 Sep 10. [Epub ahead of print] PubMed PMID: 19741730.

Cirelli JA, Park CH, MacKool K, Taba M Jr, Lustig KH, Burstein H, Giannobile WV. AAV2/1-TNFR:Fc gene delivery prevents periodontal disease progression. Gene Ther. 2009 Mar;16(3):426-36. Epub 2008 Dec 11. PubMed PMID: 19078994; PubMed Central PMCID: PMC2656404.

Ramseier CA, Kinney JS, Herr AE, Braun T, Sugai JV, Shelburne CA, Rayburn LA, Tran HM, Singh AK, Giannobile WV. Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol. 2009 Mar;80(3):436-46. PubMed PMID: 19254128.

Chang PC, Cirelli JA, Jin Q, Seol YJ, Sugai JV, D'Silva NJ, Danciu TE, Chandler LA, Sosnowski BA, Giannobile WV. Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to Alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical Use. Hum Gene Ther. 2009 Feb 6. [Epub ahead of print] PubMed PMID: 19199824.

Gapski R, Hasturk H, Van Dyke TE, Oringer RJ, Wang S, Braun TM, Giannobile WV. Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial. J Clin Periodontol. 2009 Feb;36(2):149-56. PubMed PMID: 19207891.

Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009;50:52-64. PubMed PMID: 19388953.

Lin Z, Sugai JV, Jin Q, Chandler LA, Giannobile WV. Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction. J Periodontal Res. 2008 Aug;43(4):440-9. PubMed PMID: 18823454; PubMed Central PMCID: PMC2583112.

Giannobile WV. Host-response therapeutics for periodontal diseases. J Periodontol. 2008 Aug;79(8 Suppl):1592-600. Review. PubMed PMID: 18673015; PubMed Central PMCID: PMC2583215.

Rios HF, Ma D, Xie Y, Giannobile WV, Bonewald LF, Conway SJ, Feng JQ. Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. J Periodontol. 2008 Aug;79(8):1480-90. PubMed PMID: 18672999; PubMed Central PMCID: PMC2581516.

Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, Taichman LS, D'Silva NJ, Gopalakrishnan R, Wang C, Giannobile WV, Taichman RS. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May;79(5):845-53. PubMed PMID: 18454663; PubMed Central PMCID: PMC2582372.

Shelburne CE, Shelburne PS, Dhople VM, Sweier DG, Giannobile WV, Kinney JS, Coulter WA, Mullally BH, Lopatin DE. Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients. PLoS One. 2008 Apr 23;3(4):e1984. PubMed PMID: 18431474; PubMed Central PMCID: PMC2291562.

Jin Q, Wei G, Lin Z, Sugai JV, Lynch SE, Ma PX, Giannobile WV. Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo. PLoS One. 2008 Mar 5;3(3):e1729. PubMed PMID: 18320048; PubMed Central PMCID: PMC2248711.

Preshaw PM, Novak MJ, Mellonig J, Magnusson I, Polson A, Giannobile WV, Rowland RW, Thomas J, Walker C, Dawson DR, Sharkey D, Bradshaw MH. Modified-release subantimicrobial dose doxycycline enhances scaling and root planing in subjects with periodontal disease. J Periodontol. 2008 Mar;79(3):440-52. PubMed PMID: 18315426.

Dastoor SF, Travan S, Neiva RF, Rayburn LA, Giannobile WV, Wang HL. Effect of adjunctive systemic azithromycin with periodontal surgery in the treatment of chronic periodontitis in smokers: a pilot study. J Periodontol. 2007 Oct;78(10):1887-96. PubMed PMID: 17915999; PubMed Central PMCID: PMC2581737.

Dunn MD, Park CH, Kostenuik PJ, Kapila S, Giannobile WV. Local delivery of osteoprotegerin inhibits mechanically mediated bone modeling in orthodontic tooth movement. Bone. 2007 Sep;41(3):446-55. Epub 2007 May 8. PubMed PMID: 17588510; PubMed Central PMCID: PMC2581749.

Jin Q, Cirelli JA, Park CH, Sugai JV, Taba M Jr, Kostenuik PJ, Giannobile WV. RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis. J Periodontol. 2007 Jul;78(7):1300-8. PubMed PMID: 17608585; PubMed Central PMCID: PMC2583091.

Wei G, Jin Q, Giannobile WV, Ma PX. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials. 2007 Apr;28(12):2087-96. Epub 2007 Jan 8. PubMed PMID: 17239946; PubMed Central PMCID: PMC2048538.

Herr AE, Hatch AV, Throckmorton DJ, Tran HM, Brennan JS, Giannobile WV, Singh AK. Microfluidic immunoassays as rapid saliva-based clinical diagnostics. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5268-73. Epub 2007 Mar 20. PubMed PMID: 17374724; PubMed Central PMCID: PMC1828942.

Herr AE, Hatch AV, Giannobile WV, Throckmorton DJ, Tran HM, Brennan JS, Singh AK. Integrated microfluidic platform for oral diagnostics. Ann N Y Acad Sci. 2007 Mar;1098:362-74. Review. PubMed PMID: 17435142; PubMed Central PMCID: PMC2572166.

Kinney JS, Ramseier CA, Giannobile WV. Oral fluid-based biomarkers of alveolar bone loss in periodontitis. Ann N Y Acad Sci. 2007 Mar;1098:230-51. Review. PubMed PMID: 17435132; PubMed Central PMCID: PMC2570328.

Rogers JE, Li F, Coatney DD, Rossa C, Bronson P, Krieder JM, Giannobile WV, Kirkwood KL. Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis. J Periodontol. 2007 Mar;78(3):550-8. PubMed PMID: 17335380; PubMed Central PMCID: PMC2683373.

Park CH, Abramson ZR, Taba M Jr, Jin Q, Chang J, Kreider JM, Goldstein SA, Giannobile WV. Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair. J Periodontol. 2007 Feb;78(2):273-81. PubMed PMID: 17274716; PubMed Central PMCID: PMC2581750.

Kirkwood KL, Cirelli JA, Rogers JE, Giannobile WV. Novel host response therapeutic approaches to treat periodontal diseases. Periodontol 2000. 2007;43:294-315. Review. PubMed PMID: 17214846; PubMed Central PMCID: PMC2570321.

Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH, Longaker MT, Shi S. Craniofacial tissue engineering by stem cells. J Dent Res. 2006 Nov;85(11):966-79. Review. PubMed PMID: 17062735; PubMed Central PMCID: PMC2571078.

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