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Orthodontics and Pediatric Dentistry

Hatch Lab Research

Nan Hatch, DMD, PhD
Lysle E. Johnston, Jr. Collegiate Professor of Orthodontics, Associate Professor of Dentistry
Department of Orthodontics and Pediatric Dentistry

Faculty Profile
Hatch Lab

 

 


Dr. Hatch's laboratory is focused upon elucidating essential factors and pathways that control craniofacial skeletal development and pathogenic mechanisms leading to craniofacial skeletal anomalies, with an emphasis on craniosynostosis (the premature fusion of cranial bones). Her research group has optimized protocols for qualitative and quantitative analyses of skeletal bones, which are applicable to a wide variety of craniofacial and long bone skeletal anomalies. The lab utilizes cell culture, organ culture and mouse model systems to investigate fundamental mechanisms that control lineage commitment, osteoblast differentiation, tissue mineralization, endochondral growth plate maturation and craniofacial shape. The lab also pursues collaborative research to develop 3D custom printed scaffolds to control tissue mineralization for use in tissue regenerative therapies. In addition, Dr. Hatch’s research group works to develop novel biologically based therapeutics for control of orthodontic tooth movement and retention using animal models.