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Orthodontics and Pediatric Dentistry

Faculty Profile - Dr. Nan Hatch

Nan Hatch, DMD, PhD

Lysle E. Johnston, Jr. Collegiate Professor of Orthodontics, Associate Professor of Dentistry
Orthodontics and Pediatric Dentistry
Room 4209
nhatch@umich.edu


Research
Recent Publications
Hatch Lab


Dr. Hatch received her DMD from the Harvard School of Dental Medicine in 1999. She received her orthodontic certificate in 2002 and a PhD in Molecular and Cell Biology in 2005, both from University of Washington in Seattle.  Dr. Hatch then completed three years of post-doctoral training in the University of Michigan’s Tissue Engineering and Regeneration program. She subsequently became full time faculty and was promoted to tenured Associated Professor of Dentistry at the University of Michigan, School of Dentistry in 2015.

Dr. Hatch is certified by the American Board of Orthodontists. She treats patients on Thursday mornings within the University of Michigan Orthodontic Dental Faculty Associates practice. Her practice philosophy is patient centered. Her treatment planning decisions are guided by both the dentition and facial esthetics.

Dr. Hatch serves as a didactic and clinical instructor for dental students and orthodontic residents. She also serves as Research Director for the Orthodontic Division to guide orthodontic residents as they work towards their M.S. and/or Ph.D. degrees. She has mentored numerous orthodontic residents on their research, four of whom have won research awards from the American Association of Orthodontists. She also mentors dental and graduate students.

Dr. Hatch’s research interests include basic and translational research in bone biology and the molecular etiology of craniofacial anomalies, as well as the development of biologic mediators of orthodontic tooth movement and retention. Dr. Hatch has received multiple awards for her research including the 2007 American and International Associations for Dental Research 1st Place Hatton Award, the 2008 American Society for Bone and Mineral Research Harold M. Frost Young Investigator Award, the 2010 American Society for Bone and Mineral Research John Hadded Young Investigator Award, and the 2012 American Association of Orthodontists Foundation Dewel Award. She has served on the executive committee and as president of the Internal Association for Dental Research’s Craniofacial Biology Group (2009-2016), as the Great Lakes representative to the American Association of Orthodontists Council on Scientific Affairs (2009-2015), and as a board member of the American Society for Bone and Mineral Research’s Advances in Mineral Metabolism Meeting (2015-2017). Her research has been funded by the American Association of Orthodontists Foundation, The Hartwell Foundation, the National Institute of Dental and Craniofacial Research (NIH/NIDCR) and Alexion Pharmaceuticals Inc. She holds a patent on a Tissue Nonspecific Alkaline Phosphatase as a biomedical treatment approach for craniosynostosis.


Education

1990 - BS, Psychology, Tufts University
1999 - DMD, Harvard School of Dental Medicine
2002 – Orthodontic Certificate, University of Washington
2005 – PhD, Molecular and Cell Biology, University of Washington


Academic Appointments and Professional Experience

2003 - 2004 Teaching Assistant, Biochemistry, University of Washington, Seattle, WA
2005 - 2008 Research Fellow, Tissue Engineering and Regeneration T32, School of Dentistry, University of Michigan, Ann Arbor, MI
2008 - 2015 Assistant Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI
2015 - Research Director, Division of Orthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI
2015 - Lysle E Johnston, Jr. Collegiate Professor of Orthodontics and Associate Professor of Dentistry, University of Michigan, Ann Arbor, MI

Honors, Awards and Patents

2015 Patent: Composition and Methods for Treating Craniosynostosis
The Regents of the University of Michigan
Patent #: US 62/158,964, Date Filed: 08/05/2015
Nan Hatch: Contributor (100%)
2012 Dewel Memorial Research Award, Highest Scoring Research Proposal, American
Association of Orthodontists Foundation, St. Louis, MO
2010 John Haddad Young Investigator Award, Advances in Mineral Metabolism,American Society for Bone and Mineral Research
2009 T.M. Graber Fellowship Teaching Award, American Association of Orthodontists Foundation, St. Louis, MO
2008 Harold M. Frost Young Investigator Award, Sun Valley Workshop, American Society for Bone and Mineral Research
2007 2007 Hatton Award, 1st Place, Post-doctoral Category, American Association of Dental Research
2007 2007 Hatton Award, 1st Place, Senior Basic Science Category , International Association of Dental Research

Research Interests

  • Cellular mechanisms of craniosynostosis
  • Anabolic and catabolic effects of fibroblast growth factor signaling on bone
  • Enzymatic control of tissue mineralization and cellular differentiation
  • Cranial base growth plate maturation and regulation of cranial base chondrocytes
  • Craniofacial bone growth and morphology
  • Development of scaffolds for control of tissue mineralization
  • Development of biologic mediators for local control of orthodontic tooth movement and retention.

Recent Publications

The most recent 15 publications are reported below via PubMed search. Complete List of Published Work in PubMed.

  • Liu J, Campbell C, Nam HK, Caron A, Yadav MC, Millan JL and Hatch NE (2015). Enzyme replacement for craniofacial skeletal defects and craniosynostosis in murine hypophosphatasia. Bone, 78:203-11. PMID: 25959417
  • DuRussel J, Liu J, Campbell C, Nam HK, Hatch NE. Bone mineralization dependent craniosynostosis and craniofacial shape abnormalities in the mouse model of infantile hypophosphatasia. Dev Dyn. 2015 Nov 25. doi: 10.1002/dvdy.24370. [Epub ahead of print] PubMed PMID: 26605996.
  • Ramaswamy J, Nam HK, Ramaraju H, Hatch NE, Kohn DH. Inhibition of osteoblast mineralization by phosphorylated phage-derived apatite-specific peptide. Biomaterials. 2015 Dec;73:120-30.
  • E Wang E, Nam HK, Liu J and Hatch NE (2015). The Effects of Tissue-Nonspecific Alkaline Phosphatase Gene Therapy on Craniosynostosis and Craniofacial Morphology in the FGFR2C342Y/+ Mouse Model of Crouzon Craniosynostosis. Ortho Cran Res, 18 Suppl 1:196-206. PMID: 25865549.
  • DA Schneider DA, Smith SM, Campbell C, Hayami T, Kapila* S and Hatch* NE (2015).Locally Limited Inhibition of Bone Resorption and Orthodontic Relapse by Recombinant Osteoprotegerin Protein Ortho Cran Res, 18(Suppl 1): 187-195. *co-senior authorship. PMID: 25865548.
  • Foster BL, Sheen CR, Hatch NE, Liu J, Cory E, Narisawa S, Kiffer-Moreira T, Sah RL, Whyte MP, Somerman MJ, Millán JL (2015). Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia. J Dent Res, 94(5):706-14. PMCID: PMC4502784.
  • Liu J, Nam HK, Campbell C, Gasque KC, Millán JL, Hatch NE (2014). Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(-/-) mouse model of infantile hypophosphatasia. Bone, 67C:81-94. PMID: 25014884.
  • Gasque KC, Foster BL, Kuss P, Yadav MC, Liu J, Kiffer-Moreira T, van Elsas A, Hatch N,Somerman MJ, Millán JL (2014). Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl(-/-) mice by administration of soluble (non-targeted) chimeric alkaline phosphatase. Bone, 72:137-47. PMID: 25433339.
  • Liu J, Nam HK, Wang E, Hatch NE (2013). Further Analysis of the Crouzon Mouse, Effects of the FGFR2C342Y Mutation are Cranial Bone Dependent. Calc Tissue Int 92(5):451-466. PMCID: 3631296.
  • Liu J, Kwon TG, Nam HK and Hatch NE (2013). Craniosynostosis Associated FGFR2C342Y Mutant Bone Marrow Stromal Cells Exhibit Cell Autonomous Abnormalities in Osteoblast Differentiation and Bone Formation. Biomed Res Int. 2013;2013:292506. PMCID: 3665166
  • Ponder SN, Benavides E, Kapila S and Hatch NE (2013). Quantification of External Root Resorption by Low vs. High Resolution Cone Beam Computed Tomography and Periapical Radiography: A Volumetric and Linear Analysis. Am J Orthod Dentofacial Orthop, 143(1):77-91. PMID: 23273363.
  • Hudson JB, Hatch NE, Hayami T, Shin JM, Stolina M, Kostenuik PJ, Kapila S (2012). Local Delivery of Recombinant Osteoprotegerin Enhances Post-orthodontic Tooth Stability. Calcif Tissue Int 90(4):330-42. PMID: 22382900.
  • Nam HK, Li J, Li Y, Kragor A and Hatch NE (2011). Ectonucleotide pyrophosphatase phosphodiesterase-1 (Enpp1) regulates osteoblast differentiation via a catalysis independent mechanism. J Biol Chem, 286(45):39059-71. PMCID: PMC3234731.
  • Li Y, Liu J, Hudson M, Kim S and Hatch NE (2010). FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling. J Cell Biochem, 111(5):1346-1358. PMID: 20803545.
  • Hatch NE (2010). FGF Signaling in Craniofacial Biologic Control and Pathology. Crit Rev Euk Gene Exp, Crit Rev Eukaryot Gene Expr, 20(4):295-311. PMID: 21395503.