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Orthodontics and Pediatric Dentistry

Dr. Sunil Kapila Select Publications

Selected Peer Reviewed Publications (out of 47)

1. Kapila, S. 1983. Distribution of malocclusions in African and Asian children in some Nairobi schools. Odontostomatologie Tropicale, VI: 131-137.

2. Meng, H.P., Goorhuis, J., Kapila, S., and Nanda, R.S. 1988. Growth changes in the nasal profile from 7 to 18 years. American Journal of Orthodontics and Dentofacial Orthopedics, 94:317-326.

3. Kapila, S. 1989. Cephalometric angular norms in Kikuyu children. Angle Orthodontist, 59:139-144.

4. Kapila, S. and Sachdeva, R. 1989. Mechanical properties and clinical applications of orthodontic wires. American Journal of Orthodontics and Dentofacial Orthopedics, 96:100-109.

5. Nanda, R.S., Meng, H.P., Kapila S., Goorhuis J. 1990. Growth changes in soft tissue profile. Angle Orthodontist, 60:177-90.

6. Kapila, S., Angolkar, P., Duncanson, M., and Nanda, R.S. 1990. Evaluation of friction between edgewise stainless steel brackets and orthodontic wires of four alloys. American Journal of Orthodontics and Dentofacial Orthopedics, 98: 117-126.

7. Angolkar, P., Kapila, S., Duncanson, M., Nanda R.S. 1990. Evualation of friction between ceramic brackets and orthodontic wires of four alloys. American Journal of Orthodontics and Dentofacial Orthopedics,98:499-506.

8. Curtis, D.A., Nielsen, I.L., Kapila, S., Miller A.J. 1991. Adaptability of the adult primate craniofacial complex to asymmetrical lateral forces. American Journal of Orthodontics and Dentofacial Orthopedics, 100:266-273.

9. Curtis, D.A., Kapila, S., Curtis, T., Miller, A.J.,Nielsen, I.L. 1992. Vertical dimension increases in the adult rhesus monkey: A pilot study. Journal of Prosthetic Dentistry, 67: 701-7.

10. Kapila, S., Lee, C., Richards, D.W. 1995. Characterization and identification of proteinases and proteinase inhibitors synthesized by temporomandibular joint disc cells. Journal of Dental Research, 74: 1328-36.

11. Kapila, S., Lee, C., Tavakolli-Jou, M., Miller, A., Richards, D. 1995. Development and histologic characterization of an animal model of antigen-induced arthritis of the juvenile temporomandibular joint. Journal of Dental Research, 74:1870-9.

12. Kapila, Y.L., Kapila S., Johnson, P.W. 1996. Fibronextin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biology, 15:251-261.

13. Demsari, F., van Dijke, C.F., Kirk, B.A., Kapila, S, Peterfy, C.G., Roberts, T.P.L., Shames, D.M., Mann, J., Brasch, R.C. 1996. Mapping abnormal synovial vascular permeability (PS) in temporomandibular joint arthritis in the rabbit using MRI. British Journal of Rheumatology, 35: 25-23. 

14. van Dijke, C., Kirk, B.A., Peterfy, C., Genant, H.K., Brasch, R.C., and Kapila, S. 1997. Albumin-(Gd-DTPA)30- enhanced MR imaging parameters correlate with histopathology of the arthritic temporomandibular joint. Radiology 204: 825-832.

15. Kapila, S., Xie, Y. 1998. Targeted induction of collagenase and stromelysin in unprimed and beta-estradiol-primed temporomandibular joint fibrocartilaginous cells but not in synoviocytes. Laboratory Investigation, 78:925-938. 16. Tavakkoli Jou, M., MIller, S.J., and Kapila, S. 1999. Mandibulofacial addaptations in a juvenile animal model of temporomandibular joint arthritis. Journal of Dental Research, 78: 1426-1435.

17. Quintero, J.C., Trosien, A., Hatcher, D., Kapila, S. 1999. Craniofacial imaging: Historical perspective, current status, and future developments. Angle Orthodontist, 69:491-506.

 18. van Dijke, C.F., Peterfy, C.J., Brasch, R.C., Lang, P., Roberts, T.P.L., Shames, D., Kneeland, J.B., Lu, Y., Mann, J.S., Kapila, S., Genant, H.K. 1999. MR imaging of the arthritic knee joint using albumin-(Gd-DTPA)30 with correlation to histopathology. Magnetic Resonance Imaging, 17:237-245.

19. Hu, B., Kapila, Y.L., Buddhikot, M., Shiga, M., and Kapila, S. 2000. Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin gragment in fibrocartilagenous cells: uPA contributes to activation of procollagenase-1. Matrix Biology, 19: 657-669.

20. Huynh, Q.N., Wang, S., Tafolla, E., Gansky, S.A., Kapila, S., Armitage, G.C., Kapila, Y.L. 2002. Specific fibronectin fragments as markers of periodontal disease. Journal of Periodontal Research, 73:1101-1110.

21. Shiga, M., Kapila, Y.L., Zhang, W., Hayami, T., Kapila, S. 2003. Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cels: Potential association between collagenase expression and changes in alkaline phosphatase phenotype. Journal of Bone and Mineral Reseach, 18:67-77.

22. Kapila, S. 2003. Does the relaxin, estogen, and metalloproteinase axis contribute to degradation of TMJ fibrocartilage? Journal of Musculoskeletal and Neuronal Interactions, 3:401-405.

23. Tanimoto, K., Ohno, S., Imada, M., Honda, K., Ohno-Nakahara, M., Kapila, S., Tanne, K . 2004. Utility of urinary pyridinoline and deoxygyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint. Journal of Oral Pathology and Medicine, 23: 218-23.

 24. Naqvi, T., Duong, T., Hashem, G., Shiga, M., Zhang, Q., and Kapila, S. 2004. Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants. Arthritis Research and Therapy, 7: R1-R11.

25. Tanaka, N., Ohno, S., Honda, K., Tanimoto, K., Doi, T., Ohno-Nakahara, M., Tafolla, E., Kapila, S., Tanne, K. 2005. Cyclic mechanical force regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2+ channel. Journal of Dental Research, 84:64-68.

26. Yoneno, K., Ohno, S., Tanimoto, K., Honda, K., Tanaka, N., Doi, T., Kawata, T., Tanaka, E., Kapila, S., and Tanne, K. Multi-differentiation potential of mesenchymal stem cells in three-dimensional collagen gel cultures. Journal of Biological Materials Research. Published online 18 Aug, 2005; DOI: 10.1002/jbm.a. 30488.

27. Hashem, G., Zhang, Q., Hayami, T., Chen, J., Wang, W., and Kapila, S. Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: Progesterone prevents matrix loss. 2006. Arthritis Research and Therapy. Published online 19 June, 2006; 8:R98 (

28. Jolley, L., Majurndar, S., Cassidy, C., Kapila, S. 2006. Technical factors affecting fractal analysis of periapical radiographs. Dentomaxillofacial Radiology, 35:393-397.

29. Hayami, T., Zhang, Q., Kapila, Y., and Kapila, S. 2007. Dexamethasone enhances specific markers of osteoblastic differentiation in human periodontal ligament cells by inhibiting collagenase expression. Bone, 40:93-104.

30. Dunn, M.D., Park, C.H., Kosteniuk, P.J., Kapila, S., and Giannobile, W.V. 2007. Local delivery of osteoprotegerin inhibits mechanically mediated bone modeling in orthodontic tooth movement. Bone, 41:446-455.

31. Xu, J., Wang, W., Ludeman, M., Cheng, K., Hayami, T., Lotz, J., Kapila, S. 2008. Chondrogenic differentiation of mesenchumal stem cells in 3-dimensional alginate gets. Tissue Engineering,  Part A. 14:667-680.

32. Wadhwa, S., Kapila, S. 2008. TMJ Disorders: Future innovations in diagnostics and therapeutics. Journal of Dental Education, 72:930-947.

33. Hayami, T., Kapila, Y., Kapila, S. MMP-1 (Collagenase-1) and MMP-13 (Collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biology. Aug 5, 2008. (Epub ahead of print).

34. Xu, J., Wang, W., Kapila, Y., Kapila, S. Multiple differentiation capacity of STRO=1+/CD146+ PDL mesenchymal progenitor cells. Stem Cell and Development. Jul 1, 2008. (Epub ahead of print)

35. Kapila, S., Wang, W., Uston, K. 2008. MMP induction by relaxin causes cartilage matrix degradation in target synovial joints: Receptor profiles correlate with matrix turnover. Annals New York Academy of Sciences. In Press.

36. Wang, W., Hayami, T., Kapila, S. 2008. Female hormone receptors are differentially expressed in mouse fibrocartilages. Osteoarthritis and Cartilage. DOI: 10.1016/j,joca.2008.009.015 (Epub ahead of print). 

37. Kapila, S., Xie, Y., Wang, W. Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites. Orthodontics and Craniofacial Research. In Press. 

Selected Chapters (out of 10)

1. Kapila, S., and Trosien, A. 1996. Pathophysiology and mandibulofacial aberrations in juvenile rheumatoid arthritis of the temporomandicular joint. In: Craniofacial Growth Series, Monograph Number 31. Ed: McNamara, J.A. and Trotman, C.A. Center for Human Growth and Development, Univ of Michigan, Ann Arbor, Michigan. pp:333-364. 

2. Kapila, S. 1997. Biology of Temporomandibular Joint Degeneration: The Role of Matrix Degrading Enzymes. In: Occlusion, Science, and Practice. Ed: McNeill, C. Quintessence Publishing Co, Inc. pp:235-258.

 3. Kapila, S., and Chen, J. 2000. Matrix metalloproteinases in Orthodontic Tooth Movement: Principles and Potential Applications. In: Biological Mechanisms of Tooth Movement and Craniofacial Development. Eds: Davidovitch, Z. and Mah, J. pp:107-118. 

4. Huang, J., King, G., and Kapila, S. 2005. Biologic Mechanisms of Tooth Movement. In: Biomechanics in Orthodontics. Ed: Nanda, R. Elsevier/Saunders, St. Louis, Missouri. pp:17-37. 

Selected Books and Proceedings (out of 7)

1. Kapila, S., Farman, A.G. (Editors): Craniofacial Imaging in the 21st Century. Proceedings of Conferences on Orthodontic Advances in Science and Technology Foundation. Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. 2003; 6: supplement 1.

2. King, G. and Kapila, S. (Editors): Craniofacial Skeletal Bioengineering II. Proceedings of the 2004 COAST Conference, Asilomar Conference Center, Pacific Grove, California. Orthodontics and Craniofacial Research, Munksgaard Press, Copenhagen, Denmark. 2005; vol 8 (3)

3. Kapila, S. and King, G. (Editors). Craniofacial Skeletal Bioengineering II. Proceedings of the 2004 COAST Conference. Asilomar Conference Center, Pacific Grove, California. Orthodontics and Craniofacial Research. Munksgaard Press, Copenhagen, Denmark. 2005; vol 8 (4)

4. McNamara, J.A., Kapila, S. (Editors): Digital Radiography and Three-Dimensional Imaging. Craniofacial Growth Series Monograph Number 43, Needham Press, Ann Arbor, Michigan. 2006. 

5. Nanda, R., Kapila, S. (Editors): Current Therapy in Clinical Orthodontics. Mosby Elsevier. 2009. 

6. McNamara, J.A., Kapila, S. (Editors): Temporomandibular Disorders and Orofacial Pain. Craniofacial Growth Series Monograph Number 46, Needham Press, Ann Arbor, Michigan. 2009.