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Cariology, Restorative Sciences, and Endodontics

Angiogenesis Lab - Science


  • Adenoid Cystic Carcinoma Research Foundation (ACCRF)
  • American Association for Dental Research
  • American Association of Endodontics
  • American Cancer Society
  • American Dental Association Health Foundation
  • Cancer Center, University of Michigan
  • Cariology, Restorative Sciences and Endodontics Department, School of Dentistry, University of Michigan (CRSE)
  • Comprehensive Cancer Center, University of Michigan
  • Delta Dental Foundation
  • Lilly Pharmaceuticals
  • Medimmune
  • National Cancer Institute (NIH/NCI)
  • National Institute of Dental and Craniofacial Research (NIH/NIDCR)
  • National Institute of Health (NIH)
  • United States Department of Defense


Published Articles (Peer-reviewed)

  1. Neiva KG, Warner KA, Campos MS, Zhang Z, Moren L, Danciu TE, Nör JE. Endothelial IL-6 enhances tumor growth and tumor angiogenesis. BMC Cancer 2014;14(1):99
  2. Kim JW, Choi H, Jeong BC, Oh SH, Lee BN, Oh WM, Nör JE, Koh JT, Hwang YC. Transcriptional Factor ATF6 is Involved in Odontoblastic Differentiation. J Dent Res 2014 Feb 25. [Epub ahead of print]
  3. Hildebrand LC, Carvalho AL, Lauxen IS, Nör JE, Cerski CT, Sant’Ana M. Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas. J Oral Pathol Med Feb 17. doi: 10.1111/jop.12169. [Epub ahead of print]
  4. Lauxen IS, Oliveira MG, Rados PV, Lingen MW, Nör JE, Sant´Ana Filho M. Immunoprofiling of oral squamous cell carcinomas reveals pattern of high p63 and survivin expression. Oral Diseases 2013 May 15. doi: 10.1111/odi.12136. [Epub ahead of print]
  5. Nor C, Zhang Z, Warner KA, Bernardi L, Visioli F, Helman J, Roesler R, Nör JE. Cisplatin induces Bmi-1 and enhances the stem cell fraction in head and neck cancer. Neoplasia (In press).
  6. Jeong JY, Woo SM, Koh JT, Lee BN, Nör JE, Hwang YC. Effect of Mineral Trioxide Aggregate, Biodentine and Bioaggregate on Odontoblastic Differentiation in Human Dental Pulp Cells. J Dent Res (In press).
  7. Schneider R, Holland RG, Chiego D, Hu JC, Nör JE, Botero TM. White Mineral Trioxide Aggregate induces Migration and Proliferation of Stem Cells from the Apical Papilla. J Endod (In press).
  8. Wang X, Zhang Z, Chang S, Czajka-Jakubowska A, Nör J, Clarkson B, Ni L, Liu J. Fluorapatite Enhances Mineralization of Mesenchymal/Endothelial Co-cultures. Tissue Eng. Part A. 20(1-2):12-22, 2014.
  9. Warner KA, Adams A, Bernardi L, Nor C, Herwig K, Zhang Z, McLean SA, Helman J, Wolf GT, Divi V, Queimado L, Kaye FJ, Castilho RM, Nör JE. Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Oncol 49(11):1059-66, 2013.
  10. Dong Z, Imai A, Krishnamurthy S, Zhang Z, Zeitlin BD, Nör JE. Xenograft tumors vascularized with murine blood vessels may overestimate the effect of anti-tumor drugs: a pilot study. PLOS One 8(12):e84236, 2013.
  11. Adams A, Warner K, Nör JE. Salivary Gland Cancer Stem Cells. Oral Oncol 49(9):845-53, 2013
  12. Krishnamurthy S, Nör JE. Orosphere Assay: A method for propagation of head and neck cancer stem cells. Head Neck 35(7):1015-21, 2013.
  13. Rosa V, Zhang Z, Grande RH, Nör JE. Dental pulp tissue engineering in full-length human root canals. J Dent Res 92(11):970-975, 2013.
  14. Bento LW, Zhang Z, Nör F, Dong Z, Shi S, Araujo FB, Nör JE. Endothelial differentiation of SHED requires MEK1/ERK signaling. J Dent Res 92(1):51-7, 2013 (Journal cover)
  15. Cavalcanti BN, Zeitlin BD, Nör JE. A Hydrogel Scaffold Maintains Viability and Supports Differentiation of Dental Pulp Stem Cells. Dent Mat 29(1):97-102, 2013.
  16. Hartwig F, Collares T, Nedel F, Tarquinio S, Demarco F, Nör JE. Oncogenic somatic events in tissue-specific stem cells: A role in cancer recurrence? Ageing Res Rev. 2013: S1568-1637(13)00094-9.
  17. Giudice FS, Pinto DS Jr, Nör JE, Squarize CH, Castilho RM. Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One 8(3):e58672, 2013.
  18. Wang Y, Ning Y, Alam GN, Jankowski BM, Dong Z, Nör JE, Polverini PJ. Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 Pathway. Neoplasia 15(8):989-97, 2013.
  19. Lin YL, Durmaz YY, Nör JE, El-Sayed MEH. Synergistic Inhibition of Anti-apoptotic Bcl-2 Activity by Smart, Star-shaped Vector and Small Molecule Inhibitor in Head and Neck Cancer Cells. Mol Pharm 2013;10(7):2730-8.
  20. Gomes F, Nedel F, Alves AM, Nör JE, Tarquinio SB. Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sciences 92(2):101-107, 2013.
  21. Karanxha L, Park SJ, Son WJ, Nör JE, Min KS. Combined effects of simvastatin and enamel matrix derivative on odontoblastic differentiation of human dental pulp cells. J Endod 39(1):76-82, 2013.
  22. Choi EK, Kim S, Kang IC, Jeong JY, Koh JT, Lee BN, O WM, Min KS, Nör JE, Hwang YC. Ketoprofen Inhibits Expression of Inflammatory Mediators in Human Dental Pulp Cells. J Endod 39(6):764-767, 2013.
  23. Ritchie K, Nör JE. Perivascular stem cell niche in head and neck cancer. Cancer Lett 338:41-46, 2013.
  24. Jo SY, Wang PI, Nör JE, Bellile EL, Zhang Z, Worden FP, Srinivasan A, Mukherji SK. CT Perfusion Can Predict Overexpression of CXCL8 (Interleukin-8) in Head and Neck Squamous Cell Carcinoma. AJNR Am J Neuroradiol 34(12):2338-42, 2013.
  25. Hartwig FP, Nedel F, Collares T, Tarquinio SB, Nör JE, Demarco FF. Telomeres and tissue engineering: the potential roles of TERT in VEGF-mediated angiogenesis. Stem Cell Reviews 8(4):1275-81, 2013.
  26. Imai A, Zeitlin BD, Visioli F, Dong Z, Zhang Z, Krishnamurthy S, Light E, Worden F, Wang S, Nör JE. Metronomic dosing of BH3 mimetic small molecule yields robust anti-angiogenic and anti-tumor effects. Cancer Res 72:716-725, 2012.
  27. Wang Y, Ning Y, Alam G, Visioli F, Dong Z, Nör JE, Polverini PJ. The Unfolded Protein Response Induces Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway. Cancer Res 72:5396-406, 2012.
  28. Zeitlin BD, Dong Z, Nör JE. Responsive angiogenic implanted network (RAIN) drop: a novel angiogenic assay. Lab Invest 92(7):988-998, 2012.
  29. Campos M, Neiva K, Meyers K, Krishnamurthy S, Nör JE. Endothelial derived factors inhibit anoikis of head and neck cancer stem cells. Oral Oncol 48:26–32, 2012 (Journal Cover).
  30. Zhang Z, Sant’ana M, Nör JE. The biology of head and neck cancer stem cells. Oral Oncol 48:1-9, 2012.
  31. Krishnamurthy S, Nör JE. Head and neck cancer stem cells. J Dent Res 91(4):334-40, 2012.
  32. Tarquinio S, Zhang Z, Neiva K, Polverini PJ, Nör JE. Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma. J Oral Pathol Med 41:124-130, 2012.
  33. Conde MC, Nedel F, Campos VF, Smith AJ, Nör JE, Demarco FF, Tarquinio S. Odontoblastic RNA Stability in Different temperature based protocols for Tooth Storage. Int Endod J 45:266-272, 2012.
  34. Yamanaka Y, Kaneko T, Yoshiba K, Kaneko R, Yoshiba N, Shigetani Y, Nör JE, Okiji T. Expression of angiogenic factors in rat periapical lesions. J Endod 38:313-7, 2012.
  35. Rosa V, DellaBona A, Cavalcanti BN, Nör JE. Tissue engineering: from research to dental clinics. Dent Mat 28:341-348, 2012.
  36. Liu J, Wang X, Jin Q, Jin T, Chang S, Zhang Z, Czajka-Jakubowsk A, Giannobile WV, Nör JE, Clarkson BH. The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings. Biomaterials 33(20):5036-46, 2012.
  37. Santana BP, Dos Reis Paganotto GF, Nedel F, Piva E, de Carvalho RV, Nör JE, Demarco FF, Villarreal Carreño NL. Nano-/microfiber scaffold for tissue engineering: Physical and biological properties. J Biomed Mater Res A 100(11):3051-8, 2012.
  38. Wang X, Jin T, Chang S, Zhang Z, Czajka-Jakubowska A, Nör JE, Clarkson B, Ni L, Liu J. In vitro differentiation and mineralization of dental pulp stem cells(DPSCs) on enamel-like fluorapatite surfaces. Tissue Eng Part C Methods. 18(11):821-30, 2012.
  39. Moncla BJ, Guevara PW, Wallace JA, Marcucci MC, Nör JE, Bretz W. The Inhibitory Activity of Typifi ed Propolis against Enterococcus Species. Z Naturforsch 67, 249-256, 2012.
  40. Zeitlin BD, Nör JE. Small-molecule inhibitors reveal a new function for Bcl-2 as a pro-angiogenic signaling molecule. Curr Top Microbiol Immunol 348:115-37, 2011.
  41. Wang J, Chen J, Zhang K, Zhao Y, Nör JE, Wu J. TGF-β1 regulates the invasive and metastatic potential of mucoepidermoid carcinoma cells. J Oral Pathol Med 2011;40(10):762-8.
  42. Rosa V, Botero TM, Nör JE. Regenerative endodontics in light of the stem cell paradigm. Int Dent J 61;Suppl 1:23-8, 2011.
  43. Chokechanachaisakul U, Kaneko T, Yamanaka Y, Kaneko R, Katsube K, Kobayashi H, Nör JE, Okiji T, Suda H. Gene expression analysis of resident macrophages in lipopolysaccharide-stimulated rat molar pulp. J Endod 37:1258-63, 2011.
  44. Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE. Laser-capture microdissection for Factor VIII-expressing endothelial cells in cancer tissues. Methods Mol Biol 755:395-403, 2011.
  45. Sakai VT, Cordeiro MM, Dong Z, Zhang Z, Zeitlin BD, Nör JE. Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering. Adv Dent Res 23:325-332, 2011.
  46. Kim JK, Baker J, Nör JE, Hill EE. mTor Plays an Important Role in Odontoblast Differentiation. J Endod 37:1081-1085, 2011.
  47. Cavalcanti BN, Campos MS, Nör JE. Stem cells in health and disease. Rev APCD 65:71-4, 2011.
  48. Rosa V, Botero TM, Nör JE. Regenerative endodontics in light of the stem cell paradigm. Int Dent J 61 (Suppl.1):23-28, 2011.
  49. Casagrande L, Cordeiro MM, Nör SA, Nör JE. Dental Pulp Stem Cells in Regenerative Dentistry. Odontology 99:1-7, 2011.
  50. Demarco FF, Conde MCM, Cavalcanti B, Casagrande L, Sakai V, Nör JE. Dental pulp tissue engineering. Braz Dent J 22:3-13, 2011.
  51. Morelli T, Neiva R, Nevins ML, McGuire MK, Scheyer ET, Oh TJ, Braun TM, Nör JE, Bates D, Giannobile WV. Angiogenic Markers and Healing of Living Cellular Constructs. J Dent Res 90:456-62, 2011.
  52. Hegen A, Blois A, Tiron CE, Hellesøy M, Micklem DR, Nör JE, Akslen LA, Lorens JB. Efficient in vivo vascularization of tissue engineering scaffolds. J Tissue Engin Regen Med 5(4):e52-62, 2011.
  53. Nedel F, Soki FN, Conde MC, Zeitlin BD, Tarquinio SB, Nör JE, Seixas FK, Demarco FF. Comparative analysis of two colorimetric assays in dental pulp cell density. Int Endod J 44:59-64, 2011.
  54. Zhang R, Cooper P, Smith G, Nör JE, Smith AJ. Angiogenic activity of dentin matrix components”. J Endod 37:26-30, 2011.
  55. Telles PD, Machado MA, Sakai VT, Nör JE. Pulp tissue from primary teeth: new source of stem cells. J Appl Oral Sci 19:189-94, 2011.
  56. Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE. Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 70:9969-9978, 2010.
  57. Zhang Z, Neiva K, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Diff 17:499-512, 2010.
  58. Zeitlin BD, Spalding AC, Campos MS, Ashimori N, Dong Z, Wang S, Lawrence TS, Nör JE. Metronomic small molecule inhibitor of Bcl-2 is anti-angiogenic and potentiates the anti-tumor effect of ionizing radiation. Int J Radia Oncol 78:879-887, 2010 (Highlights section).
  59. Giordano RJ, Cardó-Vila M, Salameh A, Anobom CD, Zeitlin BD, Hawke DH, Valente AP, Almeida FC, Nör JE, Sidman RL, Pasqualini R, Arap W. From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway. Proc Natl Acad Sci USA 107:5112-5117, 2010.
  60. Chokechanachaisakul U, Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE. Laser Capture Microdissection in Dentistry. Int J Dent 2010;2010:592694.
  61. Casagrande L, Demarco F, Zhang Z, Araujo FB, Shi S, Nör JE. Dentin-derived BMP2 and odontoblastic differentiation of SHED. J Dent Res 89:603-608, 2010 (Journal Cover).
  62. Sakai VT, Zhang Z, Dong Z, Neiva K, Machado M, Shi S, Santos C, Nör JE. SHED Differentiate Into Functional Odontoblasts and Endothelium. J Dent Res 89:791-796, 2010.
  63. Demarco F, Casagrande L, Zhang Z, Dong Z, Tarquinio S, Zeitlin B, Shi S, Smith A, Nör JE. The effects of morphogen and scaffold porogen on the differentiation of dental pulp stem cells. J Endod 36:1805-1811, 2010 (Journal cover).
  64. Botero TM, Son JS, Vodopyanov D, Shelburne CE, Nör JE. MAPK signaling is required for LPS-induced VEGF in pulp stem cells. J Dent Res 89:264-269, 2010 (Journal cover).
  65. Liu J, Jin T, Chang S, Czajka-Jakubowska A, Zhang Z, Nör JE, Clarkson BH. The effect of novel fluorapatite (FA) surfaces on osteoblast-like cell adhesion, growth and mineralization. Tissue Engineering Part A 16:2977-2986, 2010.
  66. Aranha A, Zhang Z, Neiva KG, Costa CA, Hebling J, Nör JE. Hypoxia enhances the angiogenic potential of human dental pulp cells. J Endod 36:1633-1637, 2010.
  67. Kim J, Shukla R, Casagrande L, Nör JE, Baker J, Hill E. Dendrimer-RGD Conjugates Enhance Dental Pulp Cell Differentiation. J Dent Res 89:1433-1438, 2010.
  68. Zeitlin BD, Ellis LM, Nör JE. A new role for the VEGF pathway: inhibition of the VEGFR1/Wnt/B-catenin pathway leads to tumor cell death. Clin Cancer Res 15:7453-7455, 2009.
  69. Doebele RC, Schulze-Hoepfner F, Hong J, Chlenski A, Zeitlin B, Goel K, Gomes S, Liu Y, Abe M, Lingen M, Nör JE, Rosner MR. A novel interplay between Epac/Rap1 and MEK5/ERK5 regulates thrombospondin production to control angiogenesis. Blood 114:4592-4600, 2009.
  70. Jain H, Nör JE, Jackson T. Quantification of Anti-Bcl-2 Therapy and its Suppression of Tumor Vascularization and Inhibition of Tumor Growth. Mol Cancer Ther 8:2926-36, 2009.
  71. Dong Z, Nör JE. Transcriptional targeting of tumor endothelial cells for gene therapy. Adv Drug Deliv Rev 61: 542-553, 2009 (Journal Cover).
  72. Neiva K, Zhang Z, Miyazawa M, Warner K, Karl E, Nör JE. Crosstalk initiated by endothelial cells enhances tumor cell survival and migration via STAT3, Akt, and ERK signaling. Neoplasia 11:583-593, 2009 (Highlighted in the cover).
  73. Ashimori N, Zeitlin BD, Zhang Z, Warner K, Spalding A, Turkienicz IM, Teknos TN, Wang S, Nör JE. TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Mol Cancer Ther 8:893-903, 2009.
  74. Soden RI, Botero T, Hanks CT, Nör, JE. Angiogenic signaling triggered by cariogenic bacteria in pulp cells. J Dent Res 88: 835-840, 2009.
  75. Kaneko T, Okiji T, Suda H, Nör JE. Gene expression analysis of immunostained endothelial cells isolated from formaldehyde-fixated paraffin embedded experimentally developed carcinoma tissue using laser capture microdissection – a Technical Report. Histochem Cell Biol 72: 908-912, 2009.
  76. Casagrande L, Falster CA, Hipolito V, Goes MF, Straffon LH, Nör JE, Araujo FB. Effect of adhesive restorations over incomplete dentin caries removal: 5-year follow-up study in primary teeth. J Dent Child 76: 117-122, 2009.
  77. Nedel F, Darvi A, Oliveira I, Cordeiro M, Casagrande L, Tarquinio S, Nör JE, Demarco F. Stem-cells: therapeutic potential in Dentistry. J Contemp Dent Practice 10: 90-96, 2009.
  78. Garcia MB, Carrilho MR, Nör JE, Anauate-Netto C, Anido-Anido A, Amore R, Tjäderhane L, Bretz WA. Chlorhexidine Inhibits the Proteolytic Activity of Root and Coronal Carious Dentin in vitro. Caries Res 43:92-96, 2009.
  79. Zeitlin BD, Zeitlin IJ, Nör JE. An expanding circle of inhibition: small molecule inhibitors of Bcl-2 as anti-cancer cell and anti-angiogenic agents. J Clin Oncol 26:4180-4188, 2008.
  80. Miyazawa M, Dong Z, Zhang Z, Neiva KG, Cordeiro MM, Oliveira DT, Nör JE. Effect of PTK/ZK on the angiogenic switch in head and neck tumors. J Dent Res 87:1166-1171, 2008.
  81. Mullane EM, Dong Z, Sedgley CM, Hu JC, Botero T, Holland GR, Nör, JE. Effect of VEGF on the revascularization of severed human dental pulps. J Dent Res 87:1144-1148, 2008.
  82. Spalding AC, Zeitlin BD, Davis M, Nör JE, Lawrence TS, Ben-Josef E. Enzastaurin, an inhibitor of PKC, enhances anti-angiogenic effects and cytotoxicity of radiation against endothelial cells. Transl. Oncol. 1:195-201, 2008.
  83. Yasuda Y, Inuyama H, Maeda H, Akamine A, Nör JE, Saito T. Cytotoxicity of one-step dentin-bonding agents toward dental pulp and odontoblast-like cells. J Oral Rehab 35:940-6, 2008.
  84. Song W, Dong Z, Mantellini M, Núñez G, Nör JE. Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells. Cancer Gene Ther 15:667-675, 2008.
  85. Warner K, Miyazawa M, Cordeiro M, Love W, Pinsky M, Neiva K, Spalding A, Nör JE. Endothelial cells enhance tumor cell invasion via a crosstalk mediated by CXC chemokine signaling. Neoplasia 10:131-139, 2008 (Highlighted in the cover).
  86. Cordeiro MMR, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, Smith AJ, Nör JE. Dental pulp tissue engineering with SHED and endothelial cells in highly porous biodegradable scaffolds. J Endod 34:962-969, 2008 (Journal Cover).
  87. Jain H, Nör JE, Jackson T. Investigating the VEGF-Bcl-2-CXCL8 Pathway in Intratumoral Angiogenesis: A Quantitative Approach. Bull Math Biol 70:89-117, 2008.
  88. Kaneko T, Okiji T, Kaneko R, Nör JE, Suda H. Antigen presenting cells in human radicular granulomas. J Dent Res 87:553-557, 2008 (Journal Cover).