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Cariology, Restorative Sciences, and Endodontics

Jacques E. Nör DDS, MS, PhD

Jacques Nor photographProfessor and Chair

Cariology, Restorative Sciences, and Endodontics
School of Dentistry, Room 2361
University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078 
TEL = 734-936-9300
FAX = 734-936-1597
EMAIL = jenor@umich.edu
additional contact information |  Complete CV 
Research Lab


Major Responsibilities:

Chair, Department of Cariology, Restorative Sciences, and Endodontics
Joint Appointment, Professor of Otolaryngology (Medical School)
Joint Appointment, Professor of Biomedical Engineering (College of Engineering)
Course Director, DENT ED 612, Molecular Biology in Clinical Dentistry
Past-Co-Director, University of Michigan Head and Neck Cancer Specialized Program in Research Excellence (SPORE)
Past-President, Pulp Biology and Regeneration Group, International Association for Dental Research (IADR)
Past-President, Michigan Section, American Association for Dental Research (AADR)

Biography:

Jacques is the Donald A. Kerr Endowed Professor of Dentistry and serves as Chair of the Department of Cariology, Restorative Sciences and Endodontics at the University of Michigan School of Dentistry. Jacques served as the Co-Director of the University of Michigan Head and Neck SPORE funded by the National Cancer Institute (NCI). He has served as a member of National Institutes of Health (NIH) study sections, and has been the principal investigator for several NIH grants. Jacques is an elected Fellow of the American Association for the Advancement of Sciences (AAAS), and recently received the Distinguished Scientist Award from International Association for Dental Research (IADR). Jacques is Associate Editor of the Journal of Dental Research and a member of the editorial board of several journals. His research interests are in salivary gland malignancies, tumor angiogenesis and in stem cell biology. His current research foci are the study of the pathobiology of cancer stem cells in head and neck squamous cell carcinomas and salivary gland cancer. More recently, his laboratory also started studies aiming at the understanding of mechanisms regulating mesenchymal stem cell differentiation in the context of tissue engineering.

Publications:

Recent Publications:

  1. Warner KA, Nör F, Acasigua GA, Martins MD, Zhang Z, McLean S, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör JE. Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res 22(14); 3550-9, 2016. PMCID: PMC4947417
  2. Nör F, Warner KA, Zhang Z, Acasigua G, Pearson AT, Kerk S, Helman JI, Sant'Ana M, Wang S, Nör JE. Therapeutic inhibition of the MDM2-p53 interaction prevents recurrence of adenoid cystic carcinomas. Clin Cancer Res 2016 Aug 22. pii: clincanres.1235.2016. [Epub ahead of print]
  3. Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhaocheng Z, Wagner VP, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, Nör JE. 5T4-targeted therapy ablates cancer stem cells and prevents recurrence of head and neck squamous cell carcinoma. Clin Cancer Res 2016 Oct 25. pii: clincanres.1834.2016. [Epub ahead of print]
  4. Zhang Z, Nör F, Oh M, Cucco C, Nör JE. Wnt/β-catenin signaling determines the vasculogenic fate of post-natal mesenchymal stem cells. Stem Cells 34(6):1576-87, 2016.
  5. Pearson AT, Jackson T, Nör JE. Modeling head and neck cancer stem cell-mediated tumorigenesis. Cell Mol Life Sciences 73(17):3279-89, 2016.
  6. Wagner VP, Martins MA, Martins MD, Warner KA, Webber LP, Squarize CH, Nör JE, Castilho RM. Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis. Oncotarget. 2016 Sep 22. doi: 10.18632/oncotarget.12195. [Epub ahead of print]
  7. Guimarães D, Martins MA, Warner KA, Vargas P, Nunes F, Squarize CH, Nör JE, Castilho RM. Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells. Oncotarget 7(27):42447-42460, 2016. PMCID: PMC5173147
  8. Machado C, Passos S, Menezes T, Vilasboas D, Nör JE, Telles PD. The dental pulp stem cell niche based on aldehyde dehydrogenase 1 expression. Int Endod J 49(8):755-63, 2016. PMCID: PMC4723291
  9. Chisini LA, Conde MC, Alcázar JC, Silva AF, Nör JE, Tarquinio SB, Demarco FF. Immunohistochemical Expression of TGF-β1 and Osteonectin in engineered and Ca(OH)2-repaired human pulp tissues. Braz Oral Res 30(1):e93, 2016.
  10. Swiecicki PL, Bellile E, Sacco AG, Pearson AT, Taylor J, Chepeha DB, Spector M, Shuman A, Malloy K, Moyer J, McKean E, McLean S, Sukari A, Wolf GT, Eisbruch A, Prince M, Bradford C, Carey T, Wang S, Nör JE, Worden F. A phase II trial of AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck squamous cell carcinoma. Invest New Drugs 34(4):481-9, 2016.
  11. Li Y, Guo T, Zhang Z, Yao Y, Chang S, Nör JE, Clarkson BH, Liu J. Autophagy Modulates Cell Mineralization on Fluorapatite-Modified Scaffolds. J Dent Res 2016 Mar 9. pii: 0022034516636852. [Epub ahead of print].
  12. Conde M, Chisini LA, Onofre R, Schuch H, Nör JE, DeMarco FF. A scoping review of Root Canal Revascularization: relevant aspects for clinical success and tissue formation. Int J Endod 2016 Oct 22. doi: 10.1111/iej.12711. [Epub ahead of print] Review.
  13. Jung JY, Woo SM, Kim WJ, Lee BN, Nör JE, Min KS, Choi CH, Koh JT, Lee KJ, Hwang YC. Simvastatin inhibits the expression of inflammatory cytokines and cell adhesion molecules induced by LPS in human dental pulp cells. Int Endod J 2016 Mar 22. doi: 10.1111/iej.12635. [Epub ahead of print]
  14. Lei Y, Prince ME, Moyer JS, Nör JE, Wolf GT. Telltale Tumor Infiltrating Lymphocytes (TIL) in Oral, Head & Neck Cancer. Oral Oncol 61:159-65, 2016.
  15. Rosa V, Dubey N, Min K, Nör JE. Pluripotency of stem cells from human exfoliated teeth (SHED) for tissue engineering. Stem Cells Int 2016;2016:5957806. PMCID: PMC4904107
  16. Finkel KA, Warner KA, Kerk S, Bradford CR, McLean SA, Prince ME, Zhong H, Hurt EM, Hollingsworth RE, Wicha MS, Tice DA, Nör JE. IL-6 inhibition with MEDI5117 decreases the fraction of head and neck cancer stem cells and prevents tumor recurrence. Neoplasia 18(5):273-81, 2016. PMCID: PMC4887598
  17. Pearson AT, Herwig KA, Warner KA, Nör F, Tice D, Martins MD, Jackson TL, Nör JE. Patient Derived Xenograft (PDX) Tumors Increase Growth Rate with Time. Oncotarget 7(7):7993-8005, 2016. PMCID: PMC4884970
  18. Kim HS, Pearson AT, Nör JE. Isolation and characterization of cancer stem cells from primary head and neck squamous cell carcinoma tumors. Methods Mol Biol 1395:241-9, 2016.
  19. Conde M, Chisini LA, Demarco F, Nör JE, Casagrande L, Tarquinio S. Stem Cell-Based Pulp Tissue Engineering: Variables enrolled in translation from the bench to the bedside, a systematized review of literature. Int Endod J 49(6):543-50, 2016.
  20. Mochizuki D, Adams A, Warner KA, Zhang Z, Pearson. AT, Kim HS, Misawa K, McLean SA, Wolf GT, Nör JE. Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. Oncotarget 6(26):22822-22835, 2015. PMCID: PMC4673202
  21. Adams A, Warner K, Pearson AT, Zhang Z, Kim HS, Mochizuki D, Basura G, Helman J, Mantesso A, Castilho RM, Wicha MS, Nör JE. ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. Oncotarget 6(29):26633-50, 2015. PMCID: PMC4694941
  22. Acasigua GA, Warner KA, Nör F, Helman J, Pearson AT, Fossati AC, Wang S, Nör JE. BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol 51(9):839-47, 2015. PMCID: PMC4532618
  23. Klein OD, Nör JE. Craniofacial Stem Cells in Health and Disease. J Dent Res 94(11):1485-6, 2015.
  24. Oh M, Nör JE. The Perivascular Niche and Self-Renewal of Stem Cells. Front Physiol 6:367, 2015. PMCID: PMC4667083
  25. Kamocki K, Nör JE, Bottino MC. Dental pulp stem cell responses to novel antibiotic-containing scaffolds for regenerative endodontics. Int Endod J 48(12):1147-56, 2015. PMCID: PMC4442767
  26. Kamocki K, Nör JE, Bottino MC. Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability-In vitro studies. Arch Oral Biol 60(8):1131-7, 2015.
  27. Conde MCM, Demarco FF, Casagrande L, Alcazar JC, Nör JE, Tarquinio SB. Influence of PLLA scaffold’s pore size on the proliferation and differentiation of Dental Pulp Stem Cells. Braz Dental J 26 (2):93-98, 2015.
  28. Jung JY, Woo SM, Lee BN, Koh JT, Nör JE, Hwang YC. Effect of Biodentine and Bioaggregate on odontoblastic differentiation via mitogen-activated protein kinase pathway in human dental pulp cells. Int Endod J 48(2):177-84, 2015.
  29. Krishnamurthy S, Meyers K, Dong Z, Imai A, Ward B, Helman JI, Taichman R, Bellile EL, McCauley L, Polverini PJ, Prince ME, Wicha MS, Nör JE. Endothelial IL-6 defines the tumorigenic potential of human head and neck cancer stem-like cells. Stem Cells 32(11):2845-57, 2014. PMCID: PMC4198458
  30. Visioli F, Wang Y, Alam G, Ning Y, Rados PV, Nör JE, Polverini PJ. Glucose-Regulated Protein 78 (Grp78) confers chemoresistance to tumor endothelial cells under acidic stress. PLoS One 25;9(6):e101053, 2014. PMCID: PMC4071032
  31. Zhang Z, Dong Z, Lauxen I, Sant’Anna M, Nör JE. Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype. Cancer Res 74(10):2869-2881, 2014. PMCID: PMC4028029
  32. Nör C, Zhang Z, Warner KA, Bernardi L, Visioli F, Helman J, Roesler R, Nör JE. Cisplatin induces Bmi-1 and enhances the stem cell fraction in head and neck cancer. Neoplasia 16(2): 137–146, 2014. PMCID: PMC3978394.
  33. Neiva KG, Warner KA, Campos MS, Zhang Z, Moren L, Danciu TE, Nör JE. Endothelial IL-6 enhances tumor growth and tumor angiogenesis. BMC Cancer 14(1):99, 2014. PMCID: PMC4016552.
  34. Piva E, Silva AF, Nör JE. Functionalized scaffolds to control dental pulp stem cell fate. J Endod 40(4 Suppl):S33-40, 2014. PMCID: PMC4034046
  35. Albuquerque MT, Valera MC, Nakashima M, Nör JE, Bottino MC. Tissue-engineering-based Strategies for Regenerative Endodontics. J Dent Res 93(12):1222-31, 2014. PMCID: PMC4237634
  36. Bretz WA, Paulino N, Nör JE, Moreira A. The Effectiveness of Propolis on Gingivitis: A Randomized Controlled Trial. J Altern Complement Med 20(12):943-8, 2014.
  37. Kim JW, Choi H, Jeong BC, Oh SH, Lee BN, Oh WM, Nör JE, Koh JT, Hwang YC. Transcriptional factor ATF6 is involved in odontoblastic differentiation. J Dent Res 93(5):483-9, 2014.
  38. Chen YC, Cheng YG, Kim HS, Nör JE, Yoon E. Paired single cell co-culture micro-environment isolated by two-phase flow with continuous nutrient renewal. Lab Chip 14(16):2941-7, 2014. PMCID:PMC4977363
  39. Guo T, Li Y, Cao G, Zhang Z, Chang S, Czajka-Jakubowska A, Nör JE, Clarkson BH, Liu J. Fluorapatite-modified Scaffold on Dental Pulp Stem Cell Mineralization. J Dent Res 93(12):1290-95, 2014.
  40. Lin YL, Jiang G, Zhang Z, Nör JE, El-Sayed MEH. Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles. J Functional Biomat 5:167-182, 2014. PMCID:PMC4192611
  41. Wu ZQ, Rowe RG, Lim KC, Lin Y, Willis A, Tang Y, Li XY, Nör JE, Maillard I, Weiss S. A Snail1/Notch1 Signaling Axis Controls Embryonic Vascular Development. Nat Comms 5;3998, 2014. PMCID: PMC4052376
  42. Hildebrand LC, Carvalho AL, Lauxen IS, Nör JE, Cerski CT, Sant’Ana M. Spatial distribution of cancer stem cells in head and neck squamous cell carcinomas. J Oral Pathol Med 43(7):499-506, 2014. PMID: 24527751
  43. Lauxen IS, Oliveira MG, Rados PV, Lingen MW, Nör JE, Sant´Ana Filho M. Immunoprofiling of oral squamous cell carcinomas reveals pattern of high p63 and survivin expression. Oral Diseases 20(3):e76-80, 2014. PMID: 23738964
  44. Schneider R, Holland RG, Chiego D, Hu JC, Nör JE, Botero TM. White Mineral Trioxide Aggregate induces Migration and Proliferation of Stem Cells from the Apical Papilla. J Endod 40(7):931-6, 2014. PMID:24935538
  45. Wang X, Zhang Z, Chang S, Czajka-Jakubowska A, Nör J, Clarkson B, Ni L, Liu J. Fluorapatite Enhances Mineralization of Mesenchymal/Endothelial Co-cultures. Tissue Eng. Part A. 20(1-2):12-22, 2014. PMCID: PMC3483051
  46. Warner KA, Adams A, Bernardi L, Nor C, Herwig K, Zhang Z, McLean SA, Helman J, Wolf GT, Divi V, Queimado L, Kaye FJ, Castilho RM, Nör JE. Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Oncol 49(11):1059-66, 2013. PMCID: PMC3821871
  47. Dong Z, Imai A, Krishnamurthy S, Zhang Z, Zeitlin BD, Nör JE. Xenograft tumors vascularized with murine blood vessels may overestimate the effect of anti-tumor drugs: a pilot study. PLoS One 8(12):e84236, 2013. PMCID: PMC3877272
  48. Adams A, Warner K, Nör JE. Salivary Gland Cancer Stem Cells. Oral Oncol 49(9):845-53, 2013. PMCID: PMC3744607
  49. Krishnamurthy S, Nör JE. Orosphere Assay: A method for propagation of head and neck cancer stem cells. Head Neck 35(7):1015-21, 2013. PMCID: PMC3887391
  50. Rosa V, Zhang Z, Grande RH, Nör JE. Dental pulp tissue engineering in full-length human root canals. J Dent Res 92(11):970-975, 2013. PMCID: PMC3797540
  51. Bento LW, Zhang Z, Nör F, Dong Z, Shi S, Araujo FB, Nör JE. Endothelial differentiation of SHED requires MEK1/ERK signaling. J Dent Res 92(1):51-7, 2013 (Journal cover). PMCID: PMC3521451
  52. Cavalcanti BN, Zeitlin BD, Nör JE. A Hydrogel Scaffold Maintains Viability and Supports Differentiation of Dental Pulp Stem Cells. Dent Mat 29(1):97-102, 2013. PMCID: PMC3515741
  53. Hartwig F, Collares T, Nedel F, Tarquinio S, Demarco F, Nör JE. Oncogenic somatic events in tissue-specific stem cells: A role in cancer recurrence? Ageing Res Rev. 2013: S1568-1637(13)00094-9. PMID: 24374269
  54. Giudice FS, Pinto DS Jr, Nör JE, Squarize CH, Castilho RM. Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One 8(3):e58672, 2013. PMCID: PMC3603970
  55. Wang Y, Ning Y, Alam GN, Jankowski BM, Dong Z, Nör JE, Polverini PJ. Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 Pathway. Neoplasia 15(8):989-97, 2013. PMCID: PMC3730049
  56. Lin YL, Durmaz YY, Nör JE, El-Sayed MEH. Synergistic Inhibition of Anti-apoptotic Bcl-2 Activity by Smart, Star-shaped Vector and Small Molecule Inhibitor in Head and Neck Cancer Cells. Mol Pharm 10(7):2730-8, 2013. NIHMSID # 495844
  57. Gomes F, Nedel F, Alves AM, Nör JE, Tarquinio SB. Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sciences 92(2):101-107, 2013.
  58. Karanxha L, Park SJ, Son WJ, Nör JE, Min KS. Combined effects of simvastatin and enamel matrix derivative on odontoblastic differentiation of human dental pulp cells. J Endod 39(1):76-82, 2013.
  59. Choi EK, Kim S, Kang IC, Jeong JY, Koh JT, Lee BN, O WM, Min KS, Nör JE, Hwang YC. Ketoprofen inhibits expression of inflammatory mediators in human dental pulp cells. J Endod 39(6):764-767, 2013.
  60. Ritchie K, Nör JE. Perivascular stem cell niche in head and neck cancer. Cancer Lett 338:41-46, 2013. PMCID: PMC3500571
  61. Jo SY, Wang PI, Nör JE, Bellile EL, Zhang Z, Worden FP, Srinivasan A, Mukherji SK. CT Perfusion Can Predict Overexpression of CXCL8 (Interleukin-8) in Head and Neck Squamous Cell Carcinoma. AJNR Am J Neuroradiol 34(12):2338-42, 2013. PMCID: PMC4270129
  62. Hartwig FP, Nedel F, Collares T, Tarquinio SB, Nör JE, Demarco FF. Telomeres and tissue engineering: the potential roles of TERT in VEGF-mediated angiogenesis. Stem Cell Reviews 8(4):1275-81, 2013.

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Updated on 01/02/2014