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Cariology, Restorative Sciences, and Endodontics

Jacques Nör, DDS, MS, PhD

Jacques Nor photographProfessor and Chair

Cariology, Restorative Sciences, and Endodontics
School of Dentistry, Room 2361
University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078 
TEL = 734-647-9396
FAX = 734-936-1597
additional contact information |  Complete CV 
Research Lab

Major Responsibilities:

Co-Director, University of Michigan Head and Neck Cancer Specialized Program in Research Excellence (SPORE)
Joint Appointment, Professor of Otolaryngology (Medical School)
Joint Appointment, Professor of Biomedical Engineering (College of Engineering)
Course Director, DENT ED 612, Molecular Biology in Clinical Dentistry
Chair, Oral Health Sciences Ph.D. Admissions Committee, School of Dentistry
Member, CRSE Department Executive Committee
Member, Cancer Research Committee, University of Michigan Cancer Center
Member, Cancer Biology Ph.D. Admissions Committee, School of Medicine
Immediate Past-President, Pulp Biology and Regeneration Group, International Association for Dental Research (IADR)
President, Michigan Section, American Association for Dental Research (AADR)
Council Delegate, Section on Dentistry and Oral Health Sciences, American Association Advancement of Sciences (AAAS)

Dr. Nör received his DDS from the Brazilian Federal University (1985), MS in Pediatric Dentistry (1992) and PhD in Oral Health sciences (1999) from the University of Michigan.
Dr. Nör research is on head and neck tumor angiogenesis, and in dental pulp tissue engineering. He served as the principal investigator for NIH grants and is Associate Editor of the Journal of Dental Research.

Description of Research Area(s):

Dr. Nör is focused on the cellular and molecular regulation of tumor angiogenesis.  In addition, his research group has worked on the use of stem cells for the engineering of dental pulps.


Recent Publications:

  1. Warner KA, Adams A, Bernardi L, Nör C, Herwig K, Zhang Z, McLean SA, Helman J, Wolf GT, Queimado L, Kaye FJ, Castilho RM, Nör JE.  Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Oncol 49(11): 1059-1066, 2013.
  2. Adams A, Warner K, Nör JE.  Salivary Gland Cancer Stem Cells. Oral Oncol 49(9):845-853, 2013.
  3. Jo SY, Wang PI, Nör JE, Bellile EL, Zhang Z, Worden FP, Srinivasan A, Mukherji SK.  CT Perfusion Can Predict Overexpression of CXCL8 (Interleukin-8) in Head and Neck Squamous Cell Carcinoma. AJNR Am J Neuroradiol 34(12): 2338-2342, 2013.
  4. Krishnamurthy S, Nör JE. Orosphere Assay: A method for propagation of head and neck cancer stem cells. Head Neck 35(7): 1015-1021, 2013.
  5. Rosa V, Zhang Z, Grande RH, Nör JE.  Dental pulp tissue engineering in full-length human root canals. J Dent Res 92(11):970-975, 2013.
  6. Bento LW, Zhang Z, Nor F, Dong Z, Shi S, Araujo FB, Nör JE.  Endodonthelial differentiation of SHED requires MEk1/ERK signing. J Dent Res 92(1):51-57, 2013 (Journal Cover).
  7. Cavalcanti BN, Zeitlin BD, Nör JE.  A Hydrogel Scaffold Maintains Viability and Supports Differentiation of Dental Pulp Stem Cells.  Dent Mat 29(1):97-102, 2013.
  8. Dong Z, Imai A, Krishnamurthy S, Zhang Z, Zeitlin BD, Nör JE. Xenograft tumors vascularized with murine blood vessels may overestimate the effect of anti-tumor drugs: a pilot study.  PLOS One (in press).
  9. Schneider R, Holland RG, Chiego D, Hu JCC, Nör JE, Botero TM.  White Mineral Trioxide Aggregate induces Migration and Proliferation of Stem Cells from the Apical Papilla. J Endod (in press).
  10. Lin YL, Durmaz YY, Nör JE, El-Sayed MEH.  Synergistic Inhibition of Anti-apoptotic Bcl-2 Activity by Smart, Star-shaped Vector and Small Molecule Inhibitor in Head and Neck Cancer Cells.  Mol Pharm 2013 Jun 18. [Epub ahead of print]
  11. Lauxen IS, Oliveira MG, Rados PV, Lingen MW, Nör JE, Sant´Ana Filho M.  Immunoprofiling of oral squamous cell carcinomas reveals patterns of high p63 and survivin expression.  Oral Diseases 2013 may 15. doi: 10.1111/odi. 12136 [Epub ahead of print]
  12. Wang X, Zhang Z, Chang S, Czajka-Jakubowska A, Nör J, Clarkson B, Ni L, Liu J. Fluorapatite Enhances Mineralization of Mesenchymal/Endothelial Co-cultures. Tissue Eng Part A. 2013 Jul 166. [Epub ahead of print]
  13. Giudice FS, Pinto DS Jr,  Nör JE, Squarize CH, Castilho RM.  Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One 8(3):e58672, 2013.
  14. Wang Y, Ning Y, Alam GN, Jankowski BM, Dong Z, Nör JE, Polverini PJ. Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 pathway. Neoplasia 15(8):989-997, 2013.
  15. Gomes F, Nedel F, Alves AM, Nör JE, Tarquinio SB.  Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms.  Life Sciences 92(2): 101-107, 2013.
  16. Karanxha L, park SJ, Son WJ, Nör JE, Min KS.  Combined effects of simvastatin and enamel matrix derivative  on odontoblastic differentiation of human dental pulp cells. J Endod 39(1):76-82, 2013.
  17. Choi EK, Kim S, Kang IC, Jeong JY, Koh JT, Lee BN, O WM, Min KS, Nör JE, Hwang YC.  Ketoprofen Inhibits Expression of Inflammatory Mediators in Human Dental Pulp Cells. J Endod 396): 764-767, 2013.
  18. Ritchie K, Nör JE.  Perivascular stem cell niche in head and neck cancer. Cancer Lett 338:41-46, 2013.
  19. Hartwig FP, Nedel F, Collares T, Tartquinio SB, Nör JE, Demarco FF.   Telomeres and tissue engineering: the potential roles of TERT in VEGF-mediated antiogenesis.  Stem Cell Reviews 8(4):1275-81, 2013.
  20. Imai A, Zeitlin BD, Visioli F, Dong Z, Kishnamurthy S, Light E, Worden F, Wang S, Nör JE.  Metronomic dosing of BH3 mimetic smal molecule yields robust anti-angiogeic and anti-tumor effects.  Cancer Res 72:716-725, 2012.
  21. Wang Y, Ning Y, Alam G, Visioli F, Dong Z, Nör JE, Polverini PJ.  The Unfolded Protein Response Induces Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway.  Cancer Res 72:5396-5406, 2012.
  22. Zeitlin BD, Dong Z, Nör JE.  Responsive angiogenic implanted network (RAIN) drop: a novel angiogenic assay.  Lab Invest 92(7): 988-998, 2012.
  23. Campos M, Neiva K, Meyers K, Krishnamurthy S, Nör JE.  Endothelial derived factors inhibit anoikis of head and neck cancer stem cells.  Oral Oncol 48:26-42, 2012 (Journal Cover).
  24. Zhang Z, Sant'ana M, Nör JE.  The biology of head an dneck cancer stem cells.  Oral Oncol 48:1-9, 2012.
  25. Krishnamurty S, Nör JE.  Head and neck cancer stem cells. J Dent Res  91(4): 334-340, 2012.
  26. Tarquinio S, Zhang Z, Neiva K, Polverini PJ, Nör JE.  Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma. J Oral Pathol Med 41:124-130, 2012.
  27. Conde MC, Nedel F, Campos VF, Smith AJ, Nör JE, Demarco FF, Tarquinio S.  Odontoblastic RNA Stability in Different temperature based protocols for Tooth Storage. Int Endod J 45:266-272, 2012.
  28. Yamanaka Y, Kaneko T, Yoshiba K, Kaneko R, Yoshiba N, Shigetani Y, Nör JE, Okiji T.  Expression of angiogenic factors in rat periapical lesions. J Endod 38:313-317, 2012.
  29. Rosa V, DellaBona A, Cavalcanti BN, Nör JE.  Tissue engineering: from research to dental clinics.  Dent Mat  28:341-348, 2012.
  30. Liu J, Wang X, Jin Q, Jin T, Chang S, Zhang Z, Czajka-Jakubowsk A, Giannobile WV, Nör JE, Clarkson BH.  The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings. Biomaterials  33(20): 5036-5046, 2012.
  31. Santana BP, Dos Resi Paganotto GF, Nedel F, Piva E, de Carvalho RV, Nör JE, Demarco FF, Villarreal Carreño NL.  Nano-/microfiber scaffold for tissue engineering: Physical and biological properties. J Biomed Mater Res A 100(11): 3051-2058, 2012.
  32. Wang X, Jin T, Chang S, Zhang Z, Czajka-Jakubowska A, Nör JE, Clarkson  B, Ni L, Liu J.  In vitro differentiation and mineralization of dental pulp stem cells (DPSCs) on enamel-like fluorapatite surfaces. Tissue Eng Park C Methods. 18(11):821-30, 2012.
  33. Moncla BJ, Guevara PW, Wallace JA, Marcucci MC, Nör JE, Bretz W. The inhibitory Activity of Typifi ed Propolis against Enterococcus Species. Z Naturforsch 67, 249-256, 2012.
  34. Zeitlin BD, Nör JE.  Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule. Curr Top Microbiol Immunol  348:115-137, 2011.
  35. Wang J, Chen J, Zhang K, Zhao Y, Nör JE, Wu J. TGF-ß1 regulates the invasive and metastatic potential of mucoepidermoid carcinoma cells. J Oral Patholo Med 2011; 40(10):762-768.
  36. Chokechanachaisakul U, Kaneko T, Yamanaka Y, Kaneko R, Katsube K, Kobayashi H, Nör JE, Okiji T, Suda H.  Gene expression analysis of resident macrophages in lipopolysaccharide-stimulated rat molar pulp. J Endod 37:1258-1263, 2011.
  37. Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE. Laser-capture microdissection for Factor VIII-expressing endothelial cells in cancer tissues. Methods Mol Biol 755:395-403, 2011.
  38. Sakai VT, Cordeiro MM, Dong Z, Zhang Z, Zeitlin BD, Nör JE.  Tooth Slice/Scaffold Model of Dental Pulp Tissue Engineering.  Adv Dent Res 23:325-332, 2011.
  39. Kim JK, Baker J, Nör JE, Hill EE. mTor Plays an Important Role in Odontoblast Differentiation. J Endod 37:1081-1085, 2011.
  40. Cavalcanti BN, Campos MS, Nör JE.  Stem cells in health and disease. Rev APCD 65:71-74, 2011.
  41. Rosa V, Botero TM, Nör JE. Regenerative endodontics in light of the stem cell paradigm. Int Dent J 61(Suppl. 1):23-28, 2011.
  42. Casagrande L, Cordeiro MM, Nör SA, Nör JE.  Dental Pulp Stem Cells in Regenerative Dentistry. Odontology 99: 1-7, 2011.
  43. Demarco FF, Conde MCM, Cavalcanti B, Casagrande L, Sakai V, Nör JE.  Dental pulp tissue engineering.  Braz Dent J 22:3-13, 2011.
  44. Morelli T, Neiva R, Nevins ML, McGuire MK, Scheyer ET, Oh TJ, Braun TM, Nör JE, Bates D, Giannobile WV.  Angiogenic Markers and Healing of Living Cellular Constructs.  J Dent Res 90:456-462, 2011.
  45. Hegen A, Blois A, Tiron CE, Helleøy M, Micklem DR, Nör JE, Akslen LA, Lorens JB.  Efficient in vivo vascularization of tissue engineering scaffolds.  J Tissue Engin Regen Med 5(4): e52-62, 2011.
  46. Nedel F, Soki FN, Conde MC, Zeitlin BD, Tarquinio SB, Nör JE, Seixas FK, Demarco FF.  Comparative analysis of two colorimetric assays in dental pulp cell density. Int Endod J 44:59-64, 2011.
  47. Zhang R, Cooper P, Smith G, Nör JE, Smith AJ. Angiogenic activity of dentin matrix components. J Endod 37:26-30, 2011.
  48. Telles PD, Machado MA, Sakai VT, Nör JE. Pulp tissue from primary teeth: new source of stem cells. J Appl Oral Sci 19:189-194, 2011.
  49. Krishnamurthy S, Dong Z, Vodopyanov D, Imai A, Helman JI, Prince ME, Wicha MS, Nör JE. endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res 70:9969-9978, 2010.
  50. Zhang Z, Neiva K, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Diff 17:499-512, 2010.
  51. Zeitlin BD, Spalding AC, Campos MS, Ashimori N, Dong Z, Wang S, Lawrence TS, Nör JE. Metronomic small molecule inhibitor of Bcl-2 is anti-angiogenic and potentiates the anti-tumor effect of ionizing randiation. Int J Radia Oncol 78:879-887, 2010 (Highlights section).
  52. Giordano RJ, Cardó-Vila M, Salameh A, Anobom CD, Zeitlin BD, Hawke DH, Valente AP, Almeida FC, Nör JE, Sidman RL, Pasqualini R, Arap W. From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway. Proc Natl Acad Sci USA 107:5112-5117, 2010.
  53. Chokechanachaisakul U, Kaneko T, Okiji T, Kaneko R, Suda H, Nör JE.  Laser Caputer Microdissection in Dentistry, Int J Dent 2010:592694, 2010.
  54. Casagrande L, Demarco F, Zhang Z, Araujo FB, Shi S, Nör JE. Dentin-derived BMP2 and odontoblastic differentiation of SHED. J Dent Res 89:603-608, 2010 (Journal Cover).
  55. Sakai VT, Zhang Z, Dong Z, Neiva K, Machado M, Shi S, Santos C, Nör JE.  SHED Differentiate Into Functional Odontoblasts and Endothelium.  J Dent Res 89:791-796, 2010.
  56. Demarco F, Casagrande L, Zhang Z, Dong Z, Tarquinio S, Zeitlin B, Shi S, Smith A, Nör JE. The effects of morphogen and scaffold porogen on the differentiation of dental pulp stem cells. J Endod 36:1805-1811, 2010 (Journal cover).
  57. Botero TM, Son JS, Vodopyanov D, Shelburne CE, Nör JE. MAPK signaling is required for LPS-induced VEGF in pulp stem cells. J Dent Res 89:264-269, 2010 (Journal cover).
  58. Liu J, Jin T, Chang S, Czajka-Jakubowska A, Zhang Z, Nör JE, Clarkson BH. The effect of novel fluorapatite (FA) surfaces on osteoblast-like cell adhesion , growth and mineralization. Tissue Engineering Part A 16:2977-2986, 2010.
  59. Aranha A, Zhang Z, Neiva KG, Costa CA, Hebling J, Nör JE. Hypoxia enhances the angiogenic potential of human dental pulp cells. J Endod 36:1633-1637, 2010.
  60. Kim J, Shukla R, Casagrande L, Nör JE, Baker J, Hill E. Dendrimer-RGD Conjugates Enhance Dental Pulp Cell Differentiation. J Dent Res 89:1433-1438, 2010.

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Updated on 01/02/2014