Cariology, Restorative Sciences and Endodontics
School of Dentistry, Room 2303
University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078
TEL = 734-763-3746
FAX = 734-936-1597
EMAIL = email@example.com
Additional information | Complete CV | Research
Course Director, DENTXXX, IMS Module 1
Course Director, DENTED606, Mineralized Tissues
Undergraduate Research Opportunity Program Faculty Recognition Award (2007)
Description of Research:
Dr. Ritchie is focused on studying two major dentin noncollagenous proteins -- dentin sialoprotein (DSP) and physophporyn (PP) -- whose appearance is coupled to the conversion of uncalcified predentin to calcified dentin. The work encompassess following four DSP-PP related areas: (1) regulation and function of rat dentin sialoprotein and phosphophoryn, (2) tissue engineering to test whether DSP and PP proteins can serve as biomimetic molecules in promoting dentin regeneration, (3) DSP-PP gene expression in non-mineralized tissues such as bone, kidney and salivary glands during organogenesis, and (4) DSP-PP precursor processing studies.
- Yang RT, Lim GL, Dong ZH, Lee AR, Yee CT, Fuller RS, Ritchie HH. The efficiency of Dentin sialoprotein-Phosphophoryn processing by mutations both flanking and distrant from the clevage site. J Biol Chem 2013 February 22; 288(8): 6024-6033.
- Ritchie HH, Yee CT, Tang X, Fuller RS. DSP-PP Precursor Protein Cleavage by Toll related-1 protein and Bone Morphogenetic Protein-1. PLoS ONE 2012 July; 7(7):341110.
- Tang XN, Zhu YQ, Marcelo CL, Ritchie HH. Expression of mineralized tissue associated proteins: Dentin sialoprotein and phosphophoryn in rodent hair follicles. J Dermatological Science 2011 Nov; 64(2): 92-98.
- li LF, Zhu YQ, Jiang L, Peng WW, Ritchie HH. Hypoxia promotes mineralization of human dental pulp cells. J Endod 2011 April; 37(6): 799-802.