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Biologic and Materials Sciences and Division of Prosthodontics

Mishina Lab Publications

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1. Mishina, Y., Mark C. Hanks, M.C., Miura, S., Tallquist, M.D., and Behringer, R.R.: Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 32: 66-72, 2002.

2. Takeda, H., Takami, M., Oguni, T., Tsuji, T., Yoneda, K., Sato, H., Mishina, Y., Ihara, N., Itoh, T., Morimoto, Y., Sugimoto, Y., and Kunieda, T. Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism. Proc. Natl. Acad. Sci. USA. 99: 10549-10554, 2002.

3. Jamin, S.P., Arango, N.A., Mishina, Y., Hanks, M.C., and Behringer, R.R. Requirement of Bmpr1a for Mllerian duct regression during male sexual development. Nat. Genet. 32: 408-410, 2002.

4. Takeuchi, A., Mishina, Y., Miyaishi, O., Hasegawa, T., and Isobe, K-I.: Heterozygosity with respect to Zfp 148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat. Genet. 33: 172-176, 2003. 5. Miura, S., and Mishina, Y.: Whole embryo in vitro culture of E5.

5 mouse embryos: development to the mid-late streak stage. Genesis. 37:38-43, 2003.

6. Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R.R., Taketo, M.M., Crenshaw III, E.B., and Birchmeier, W.: Genetic interaction between Wnt/b-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev. 17: 1963-1968, 2003.

7. Feng, J. Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T. W., Kunieda, T., Castranio, T., Scott, G., Bonewald, L. B., and Mishina, Y.: The Dentin Matrix Protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J. Dent. Res. 82: 776-780, 2003.

8. Zhang, J., Niu, C., Huang, H., Ye, L., He, X., Haug, J., Johnson, T., Feng, J. Q., Mishina, Y., and Li, L.: Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 425: 836-841, 2003.

9. Suzuki, K., Bachiller, D., Chen, Y. P., Kamikawa, M., Ogi, H., Haraguchi, R., Ogino, Y.,

10. Yuhki, M., Yamada, M., Kawano, M., Iwasato, T., Itohara, S., Yoshida, H., Ogawa, M., and Mishina, Y.: BMP receptor IA signaling is necessary for follicle cycling and hair shaft differentiation. Development. 131: 1825-1833, 2004.

11. Qi, X., Li, T. G., Hao, J., Hu, J., Wang, J., Simmons, H., Miura, S., Mishina, Y., and Zhao, G. Q.: BMP4 supports self-renewal of embryonic stem cells by inhibiting extracellular receptor kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways. Proc. Natl. Acad. Sci. USA. 101: 6027-6032, 2004.

12. Mishina, Y., Starbuck, M.W., Gentile, M. A., Fukuda, T., Seedor, G. J., Hanks, M.C., Amling, M., Harada, S., Pinero, G. J., and Behringer, R.R.: BMP type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J. Biol. Chem. 279:27560-27566, 2004.

13. Davis, S., Miura, S., Hill, C., Mishina, Y., and Klingensmith, J.: BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev. Biol. 270: 47-63, 2004.

4. Kishigami, S., Yoshikawa, S., Castranio, T., Okazaki, K., Furura Y., and Mishina, Y. BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev. Biol. 276:185-193, 2004.

15. He, X., Zhang, J., Tong, W. G., Tawfik, O., Ross, J., Scoville, D. H., Tian Q., Zeng, X., He, X., Wiedemann, L. M., Mishina, Y., and Li, L.: BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat. Genet. 36:1117-1121, 2004.

16. Rountree, R.B., Schoor, M., Chen, Hao, Marks, M. E., Mishina, Y., and Kingsley, D. M.: BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biology. 2:1815-1827, 2004.

17. Ye, L*, Mishina, Y.*, Chen, D., Huang, H., Dallas, S., Dallas, M., Kunieda, T., Tsutsui, T. W., Boskey, A. L., Bonewald L. F. and Feng, J. Q.:Dmp1-Deficient Mice Display Severe Defects in Cartilage Formation and a Chondrodysplasia-like Phenotype. J. Biol. Chem. 280:6197-6203, 2005. *Equally contributed.

18. Fukuda, T., Mishina, Y., Walker, P. M., and DiAugustine, R. P.: A conditional transgenic system for mouse Aurora A kinase: Degradation by the ubiquitin proteasome pathway controls level of the transgenic protein. Mol. Cell. Biol. 25:5270-5281, 2005.

19. Kishigami, S., Komatsu, Y., Takeda, H., Nomura-Kitabayashi, A., Yamauchi, Y., Abe, K., Yamamura, K., and Mishina, Y.: An optimized LacZ staining method for simultaneous detection of lacZ activity and endogenous gene expression in early mouse embryos. genesis 44:57-65, 2006.

20. Eblaghie, M. C., Reedy, M., Oliver, T., Mishina, Y., and Hogan, B.L. M. Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and behavior of distal ling epithelial progenitors. Dev. Biol. 291:67-82, 2006. (Published online January 13, 2006)

21. Fukuda, T., Komatsu, Y., Scott, G., Araya, R., Kawano, M., Ray, M. R., Yamada, M., and Mishina, Y.: Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. genesis 44:159-167, 2006.

22. Miura, S., Davis, S., Klingensmith, J. and Mishina, Y.: BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 133:3767-3775, 2006. (Published on line Aug. 30, 2006)

23. Zhang, J., He, X. C., Tong., W. G., Johnson, T., Wiedemann, L. M., Mishina, Y., Feng, J. Q., and Li, L.: BMP signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells 24:2826-2839, 2006. (Published online Sep. 7, 2006).

24. Komatsu, Y., Scott, G., Nagy, A., Kaartinen, V., and Mishina, Y.: BMP type I receptor ALK2 is essential for proper mesoderm patterning at late gastrulation during mouse embryogenesis. Dev. Dyn. 236:512-517, 2007.

25. Khalil, I. A., Kogure, K., Futaki S., Hama S., Akita H., Ueno M., Kishida H., Kodoh M., Mishina Y., Kataoka, K., Yamada M., and Harashima, H. Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Gene Therapy. 14:682-689, 2007. (Published on line Feb. 1, 2007)

26. Goulley, J., Dahl, U., Baeza, N, Mishina, Y., and Edlund, H.: BMP4-BMPRIA signaling in beta-cells is required for and augments glucose stimulated insulin secretion. Cell Met. 5:207-209, 2007.

27. Miura, S., and Mishina, Y.: Anterior visceral endoderm at E5.5 is required for anterior-posterior axis development and later for proper primitive streak formation. Dev. Dyn. 236:1602-1610, 2007.

28. Di-Gregorio, A., Sancho, M., Vella, F., Godwin, J., Mishina, Y., and Rodriguez, T.: BMP signaling via Bmpr1a is required to prevent neural differentiation of the epiblast and to maintain trophoblast stem cell identity. Development. 134:3359-3369, 2007.

29. Okada, Y., Scott, G., Ray, M. K., Mishina, Y., and Zhang, Y.: Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 450:119-123, 2007.

30. Feng, J.Q., Scott, G., Guo, D., Jiang, B., Ward, T., Ray, M., Bonewald, L., Harris, S. E., and Mishina, Y.: Generation of a conditional null allele for Dmp1 in mouse. Genesis 46:87-91, 2008.

31. OBryan, M. K., Takada, S., Kennedy, C., Scott, G., Harada, S., Dai, Q., Kretser, D. M., Eddy, E. M., Koopman, P., and Mishina, Y.: Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev. Biol. 316:359-370, 2008.

32. Singh, A. P., Castranio, T., Scott, G., Guo, D., Harris, M. A., Ray, M., Harris, S. E. and Mishina, Y.: Influence of reduced expression of Bone morphogenetic protein 2 on mouse embryonic development. Sexual Dev. In press

33. Inagaki, M., Komatsu, Y., Scott, G., Ray, M.K., Yamada, G., Ninomiya-Tsuji, J. and Mishina, Y.: Generation of a conditional mutant allele for Tab1 in mouse. genesis In press

34. Kamiya, N., Ye, L., Kobayashi, T., Lucas, D. J., Mochida, Y., Yamauchi, M., Kronenburg, H., Feng, J. Q., and Mishina, Y.: Disruption of BMP Signaling in Osteoblasts through Type IA Receptor (BMPRIA) Increases Bone Mass. J. Bone Miner. Res. In press. (Published on line Aug. 6, 2008).

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