Biologic and Materials Sciences Graduate Program Courses
- 601. Teaching and Learning in Dental Education. (1) Green
This course addresses basic teaching methodologies relevant to dental education. Topics include teaching and learning approaches, instructional design, evaluating, and improving instruction. Instructional strategies important in one-to-one teaching, small group teaching, lecturing, and problem-based learning are also covered.
- 602. Neural Basis of Oral and Facial Function. (1) R. Bradley, Mistretta, Gerstner, Kowalski.
This course deals with the basic neural mechanisms underlying sensation and neuromuscular activity in the oral and facial areas. The course presents basic material relating to the neurobiology of the senses of pain, taste, olfaction, and somatosensation. Neural control of motor activity involved in kinesthesia, mastication, swallowing, and speech are discussed. Throughout the course each topic is related to clinical problems to emphasize how basic knowledge can be used to understand and improve treatment of disorders of sensory and motor functions of the oral and facial areas. Students will be required to evaluate pertinent literature related to course subject matter.
- 603. Craniofacial Development and Growth. (1) Johnston, Jr., staff
This course provides the dental specialty student with a broad, systematic survey of contemporary thought in the field of craniofacial development and growth. Starting with the molecular biology of the gene, the course progresses to an examination of craniofacial morphogenesis and teratogenesis. It then examines basic concepts of physical growth and, region by region, the mechanisms of postnatal craniofacial growth and adaptation and their interaction with common modalities of treatment. The course ends with an overview of a variety of craniofacial anomalies, malformations, and syndromes.
- 604. Host-Parasite Interactions in the Oral Cavity. (1) Clewell, Lopatin, Loesche, Drach, Fenno
Recent advances in understanding the host-parasite interactions involved in caries, periodontal disease, herpes, vital hepatitis, and AIDS are explored. Emphasis is also placed on the diagnosis, treatment, and control of these infectious processes.
- 606. Mineralized Tissues. (1) Franceschi, Chiego, McCauley, Taichman, Clarkson, Somerman
This course discusses fundamental concepts related to the formation and repair of bones and teeth. Specific topics include the embryological origin and anatomy of mineralized tissues, bone formation, growth and remodeling, tooth formation and remineralization, as well as the response of mineralized tissues to specific stresses such as fractures, caries, tooth movement, dental implants, and periodontal disease. Emphasis will be placed on applying basic science concepts to specific clinical conditions.
- 607. Human Cellular and Molecular Pathophysiology. (1) Polverini, staff
The overall objective of this course is to provide the student with a concise, in-depth overview of selected topics in human biology and pathology. Three general topic areas are addressed representing major pathophysiological disciplines. The intent of the course is not to expect students to become experts in any of these areas, but rather to have them develop an appreciation of how current knowledge in each area affects the diagnosis and treatment of patients with dental and medical disease. A key component of this course is the proposed case representations. Students will be expected to report orally on papers and/or clinical case histories in which the fundamental processes discussed in the lecture/seminars are best exemplified.
- 609. Biostatistics and Research Design. (1) Kowalski
This course is designed to enable dental students to understand the statistical aspects of dental research literature. In particular, students will learn enough about study design and data analysis to appreciate what a variety of statistical techniques are designed to accomplish and to identify gross departures from accepted design and analysis strategies.
- 610. Scientific Communications. (1) Lopatin, Fiegal, Kowalski
This course addresses a variety of issues in scientific communication. Topics include development of research proposals, writing styles, literature review, preparation of abstracts and manuscripts, the publication process, and oral presentation. Opportunities will be provided for the practice of these various forms of communication.
- 814. Gene Expression: Basic and Clinical Aspects. (2) Clewell, staff
This course addresses basic aspects of gene expression as it relates to both prokaryotes and eukaryotes. Examples will include some of these being studied in research laboratories within the dental school.
Biomaterials Graduate Curriculum
- 410. Biomedical Materials. (3) Kohn
This course focuses on biomaterials and their physiological interactions. Included are materials used in medicine and dentistry- metals, ceramics, polymers, composites, smart, natural materials; material response/degeneration, mechanical breakdown, corrosion, dissolution, leaching, chemical degradation, and wear; and host responses, foreign body reactions, inflammation, wound healing, local and systematic effects.
- 566. Graduate Biomaterials. I. (2) O'Brien, staff
The course is designed for graduate students in operative dentistry, crown and bridge, or biomaterials. It consists of lecture and discussion sessions and review of standard and new materials used in restorative dentistry and a review of current literature
- 571. Testing Procedures in Biomaterials. Prerequisite: Biomat. 566 (or special permission). II and IIIa (to be arranged, maximum 4) Kohn, Ma, Mooney, O'Brien, staff
The laboratory experiments include mechanical testing, thermal analysis, physical metallurgy, experimental stress analysis, adsorption and wetting measurements, and specification testing.
- 572. Special Laboratory Project in Biomaterials. Prerequisite: Biomat. 566 or concurrently. (To be arranged, maximum 4) Section 067, Kohn; Section 016, O'Brien; Section 050, Mooney; Section 058; Ma
This course, designed to introduce the graduate student to research in biomaterials, involves preparing a research proposal, conducting a limited research study and submitting a satisfactory report of findings.
- 573. Special Topics in Biomaterials. Prerequisite: Biomat. 566. I, II, and IIIa. (2) Kohn, O'Brien, Ma, Mooney
Topics of importance not sufficiently covered in other basic science courses are discussed. Such topics as the metallurgy of precious metals, stress analysis, composite materials, and surface phenomena are presented by the staff and discussed with and by the students. The course is designated for students who plan a graduate degree in biomaterials.
- 574. Special Topics in Biological Science and Clinical Dentistry. Prerequisite: Biomat. 566. II and IIIa. (2) Kohn, Koran, O'Brien, Ma, Mooney
Topics such as cell biology, oral histology, pathology, operative and prosthetic dentistry, and endodontics and therapeutics are presented in survey lectures by members of the various basic science and clinical departments. The course is designed for students having a physical science background who plan to obtain a graduate degree in biomaterials. It should provide an understanding of the relationship between biological sciences, clinical science, and restorative materials.
- 576. Formulation of Dental Biomaterials. Prerequisite: Biomat. 566. I & II. (3) O'Brien
A combined seminar and laboratory course on the composition and processes used to produce clinically acceptable materials. The laboratory involves the preparation and determination of physical and mechanical properties of such materials as cements, restorative resins, ceramics, and alloys.
- 577. Mechanics of Orthodontic Materials. Ia. (1) Christiansen
Discussion of physical properties of spring materials, spring constants, bending moment, force couples, geometry of arch wires, friction of wire in brackets, and force application to teeth.
- 579. Investigation Leading to Thesis. Prerequisite: Biomat. 566. I, II, IIIa. (To be arranged, maximum 6) Section 067, Kohn; Section 016, O'Brien; Section 050; Mooney; Section 058, Ma
A thesis proposal is prepared and approved. A thesis research is conducted and submitted as an acceptable thesis and defended.
- 582. Engineering Fundamentals Related to Biomaterials. Prerequisite: Biomat. 566. I, II, IIIa. (3) Staff.
The following topics are discussed and problems assigned: unit cells; density calculations; effects of stress and temperature on structures; phase diagrams; nonequilibrium reaction-metal processing; Al, Mg, Ni, and Cu alloys; iron-carbon diagram; plain carbon steels; heat treatment of steels; alloy steels; iron; high-strength steels; ceramics; unit cells; materials, and processing; polymers: structure, properties, and processing; mechanical properties; corrosion of metals, polymers, and ceramics.
- 583. Biomaterials: Biocompatibility. II (3) Hanks
This course is for graduate students still interested in both materials and the biological sciences. It presupposes students have an adequate background in cell biology and biochemistry. Thus the course is listed as an elective course for Ph.D. students in Oral Health Sciences and master�s level students in the dental school, and graduate students in the bioengineering program and in material science and engineering in the College of Engineering. This course discusses the biological aspects of in vitrobiocompatibility of synthetic and biologically altered materials with tissues and cells of the human body. Lectures are by course director and invited speakers. Topics include cell and molecular biology, pathologic processes involved in non-biocompatible reactions, various strategies and approaches to investigating tissue reactions in response to materials, issues related to FDA approval of materials, requirements for meeting various standards, tissue engineering, implants, and implant retrieval, and other related subjects. Evaluation of student performance is by means of a term paper, a short oral presentation, and a final essay exam.
- 584. Biomaterials: Tissue Engineering. I (3) Mooney
Tissue engineering is an emerging field in which engineers, biologists, and clinicians together are attempting to create functional tissues utilizing cells and biomaterials. This course introduces students to the clinical need driving this field, the fundamental engineering and biological principles one must consider when engineering a tissue, and the various strategies currently being pursued to engineer a wide range of tissues and organs. Critical issues in this field include biomaterials development. Teams of students will work together during the final portion of the course to develop a strategy for engineering a tissue/organ of their choice.
- 585. Biomaterials: Clinical Research Rotation. (2) O'Brien
This course is designed for graduate students seeking experience in clinical research. The student will join a clinical research project in progress and participate in collecting and analyzing data under the direction of the principal investigator. The course is required for students who intend to do a clinically oriented thesis.
- 990. Disseration/Precandiate. (To be arranged, 2-8; half-term 1-4 only.) Section 067, Kohn; Section 016, O'Brien; Section 058, Ma
Research is planned, conducted, and written as a partial requirement for a joint PhD degree in biomaterials and a second appropriate basic science. Election for dissertation work by doctoral student not yet admitted to status as candidate.
- 995. Dissertation/Candidate. Prerequisite: Graduate School authorization for admission as a doctoral candidate. (8 only; half term, 4 only; election for half-term not permitted for period in which candidate has final examination.) Section 067, Kohn; Section 016, O'Brien; Section 050, Mooney; Section 058, Ma
Election for dissertation work by doctoral student who has been admitted to status as a candidate.
Biologic and Materials Sciences Graduate Curriculum
- 672. Orientation to Research in Oral Biology and Biomaterials. I (2) Clewell, staff
This course familiarizes the student with the ongoing research activities of the program faculty and techniques employed in these efforts.
- 676. Clinical Dental Pharmacology. IIIa. (1) B. Bradley
Pertinent aspects of basic pharmacology will be correlated with drug therapy in clinical dentistry. The major portion of the course is concerned with the classes of drugs most frequently used by the dentist. Emphasis is on drug interactions and therapy in patients with medical problems.
- 678. Statistical Methods in Oral Biology: Prerequisite: Permission of instructor. I. (2) Kowalski
This course is devoted to studying intermediate level statistical methods used in oral sciences. Emphasis is on the design of experiments, analysis of variance and regression models, and multivariate statistical methods. Special topics of interest are also included.
- 679. Cariology. II. Even numbered years. (2) Loesche
Dental caries is discussed from the perspective that decay is a specific bacterial infection due to streptococcus mutans. Evidence implicating streptococcus mutans both in humans and in animals will be presented. The interactions of this microbe with sucrose are discussed, as are therapeutic strategies and tactics to reduce streptococcus mutans in dental plaque.
- 680. The Bacteriology of Periodontal Disease. II. Odd numbered years. (2) Loesche
Periodontal disease is an inflammatory reaction toward a bacterial infection on the tooth surfaces at the dentogingival margin. Criteria used to demonstrate microbial specificity in a chronic infection are discussed in relation to periodontal disease. Evidence demonstrating that this infection may be a specific anaerobic process is presented. Advances in research related to microbial etiology, pathogenesis, and diagnostic methods are reviewed. Strategies and tactics for the treatment of anaerobic infections are also presented.
- 773. Directed Research. I, II, IIIa, IIIb. (1-4) Staff
Matters pertinent to selected areas of oral biology and biomaterials are explored through one-to-one instruction by one or more staff members. The course provides the student with an opportunity to learn and appreciate the nature of projects, available techniques and their limitations, and problems characteristic to the particular area of research in the mentor�s laboratory. This course also fulfills the requirement for students to complete research rotations of one term each in the laboratory of two faculty members. Permission of instructor.
- 774. Oral Sensation. Prerequisite: Permission of instructor. I. (1) R. Bradley
Basic principles of sensory physiology and the neurobiology of sensory receptors in the orofacial area are presented.
- 852. Advanced Prenatal Facial Growth. Prerequisite: Permission of instructor. I. (1-2) Staff
A microscopic and gross description of prenatal cranial, facial, oral, and pharyngeal growth is considered. Normal development of these structures and a discussion of the possible etiology of defective development of these areas are emphasized. Two-credit selection requires the writing of a term paper based on extensive consideration of the literature.
- 853, 854. Design and Analysis in Research. 853, I; 854, II. (2 each) Kowalski
The use of statistical methodology in research is examined. Major topics covered include descriptive statistics, elements of probability theory, analysis of variance, regression and correlation, tests of proper fit, and experimental design. The emphasis is on statistical concepts which may be helpful to the research worker in the design and analysis of experiments.
- 856. Clinical Conscious Sedation. Prerequisites: Oral Diag. 644 or equivalent, and Oral Bio. 855. I, II, IIIa. (1) B. Bradley.
The student learns through clinical experience the use of conscious sedative techniques. Credit is earned after completing of an appropriate number of supervised cases.
- 857. Current Topics in Oral Histology. Prerequisite: Permission of instructor. I. (I) Chiego, staff.
The embryology, histology, and function of the teeth, periodontium, salivary glands, and temporomandibular joint are discussed in light of current literature pertinent to the area.
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